Assessment of Commercial Off-the-Shelf Tissue Adhesives for Sealing Military-Relevant Corneal Perforation Injuries

2021 ◽  
Author(s):  
Eric J Snider ◽  
Lauren E Cornell ◽  
Brandon M Gross ◽  
David O Zamora ◽  
Emily N Boice
Keyword(s):  
Intraocular Pressure ◽  
High Speed ◽  
Anterior Segment ◽  
Ocular Tissue ◽  
Corneal Tissue ◽  
Corneal Perforation ◽  
Tissue Adhesives ◽  
Open Globe ◽  
Wide Range ◽  
Commercial Off The Shelf

ABSTRACT Introduction Open-globe ocular injuries have increased in frequency in recent combat operations due to increased use of explosive weaponry. Unfortunately, open-globe injuries have one of the worst visual outcomes for the injured warfighter, often resulting in permanent loss of vision. To improve visual recovery, injuries need to be stabilized quickly following trauma, in order to restore intraocular pressure and create a watertight seal. Here, we assess four off-the-shelf (OTS), commercially available tissue adhesives for their ability to seal military-relevant corneal perforation injuries (CPIs). Materials and Methods Adhesives were assessed using an anterior segment inflation platform and a previously developed high-speed benchtop corneal puncture model, to create injuries in porcine eyes. After injury, adhesives were applied and injury stabilization was assessed by measuring outflow rate, ocular compliance, and burst pressure, followed by histological analysis. Results Tegaderm dressings and Dermabond skin adhesive most successfully sealed injuries in preliminary testing. Across a range of injury sizes and shapes, Tegaderm performed well in smaller injury sizes, less than 2 mm in diameter, but inadequately sealed large or complex injuries. Dermabond created a watertight seal capable of maintaining ocular tissue at physiological intraocular pressure for almost all injury shapes and sizes. However, application of the adhesive was inconsistent. Histologically, after removal of the Dermabond skin adhesive, the corneal epithelium was removed and oftentimes the epithelium surface penetrated into the wound and was adhered to inner stromal tissue. Conclusions Dermabond can stabilize a wide range of CPIs; however, application is variable, which may adversely impact the corneal tissue. Without addressing these limitations, no OTS adhesive tested herein can be directly translated to CPIs. This highlights the need for development of a biomaterial product to stabilize these injuries without causing ocular damage upon removal, thus improving the poor vision prognosis for the injured warfighter.

scholarly journals Characterization of an anterior segment organ culture model for open globe injuries

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eric J. Snider ◽  
Emily N. Boice ◽  
Brandon Gross ◽  
Jacinque J. Butler ◽  
David O. Zamora
Keyword(s):  
Intraocular Pressure ◽  
Organ Culture ◽  
High Speed ◽  
Anterior Segment ◽  
Tissue Adhesive ◽  
Open Globe Injury ◽  
Current Standard ◽  
Post Injury ◽  
Open Globe ◽  
Open Globe Injuries

AbstractOpen-globe injuries have poor visual outcomes and have increased in frequency. The current standard of care is inadequate, and a therapeutic is needed to stabilize the injury until an ophthalmic specialist is reached. Unfortunately, current models or test platforms for open-globe injuries are insufficient. Here, we develop and characterize an open-globe injury model using an anterior segment organ-culture platform that allows therapeutic assessment for up to 72 h post-injury. Anterior segments maintained in organ culture were kept at physiological intraocular pressure throughout, and puncture injuries were created using a novel pneumatic-powered system. This system can create high-speed, military-relevant injuries up to 4.5 mm in diameter through the cornea. From intraocular pressure readings, we confirmed a loss of pressure across the 72 h after open-globe injury. Proof-of-concept studies with a Dermabond tissue adhesive were performed to show how this model system could track therapeutic performance for 72 h. Overall, the organ-culture platform was found to be a suitable next step towards modeling open-globe injuries and assessing wound closure over the critical 72 h post-injury. With improved models such as this, novel biomaterial therapeutics development can be accelerated, improving care, and, thus, improving the prognosis for the patients.

scholarly journals The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Giacinto Triolo ◽  
Piero Barboni ◽  
Giacomo Savini ◽  
Francesco De Gaetano ◽  
Gaspare Monaco ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Clinical Relevance ◽  
Anterior Segment ◽  
Angle Closure ◽  
Current Evidence ◽  
Optical Coherence ◽  
Iridocorneal Angle ◽  
Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

Microfabrication research at the National Submicron Facility

1983 ◽  
Vol 41 ◽  
pp. 86-89
Author(s):  
E.D. Wolf
Keyword(s):  
Integrated Circuits ◽  
Particle Physics ◽  
High Speed ◽  
New Technology ◽  
High Energy ◽  
High Energy Particle ◽  
New Science ◽  
Wide Range ◽  
Intermediate Domain ◽  
Circuit Function

Most microelectronics devices and circuits operate faster, consume less power, execute more functions and cost less per circuit function when the feature-sizes internal to the devices and circuits are made smaller. This is part of the stimulus for the Very High-Speed Integrated Circuits (VHSIC) program. There is also a need for smaller, more sensitive sensors in a wide range of disciplines that includes electrochemistry, neurophysiology and ultra-high pressure solid state research. There is often fundamental new science (and sometimes new technology) to be revealed (and used) when a basic parameter such as size is extended to new dimensions, as is evident at the two extremes of smallness and largeness, high energy particle physics and cosmology, respectively. However, there is also a very important intermediate domain of size that spans from the diameter of a small cluster of atoms up to near one micrometer which may also have just as profound effects on society as “big” physics.

Heritability of the Effect of Corticosteroids on Intraocular Pressure

1970 ◽  
Vol 19 (1-2) ◽  
pp. 264-267 ◽  
Author(s):  
F.H. Reuling ◽  
J.T. Schwartz
Keyword(s):  
Intraocular Pressure ◽  
Clinical Signs ◽  
Topical Steroids ◽  
Frequency Distributions ◽  
Steroid Response ◽  
Large Numbers ◽  
Wide Range ◽  
Allele Pair ◽  
High Level ◽  
Genetically Determined

In the late 1950's and early 1960's, it became evident that some glaucoma patients developed elevations of intraocular pressure, which were difficult to control, following prolonged use of systemic or ocular medications containing corticosteroids (Chandler, 1955, Alfano, 1963; Armaly, 1963). In addition, some patients without glaucoma, when treated with steroids for long periods of time, developed clinical signs of chronic simple glaucoma (McLean, 1950; François, 1954; Covell, 1958; Linner, 1959; Goldman, 1962). Fortunately, the elevation of intraocular pressure was reversible if the drug was discontinued.Over the past decade, extensive investigation of the “steroid response” has been undertaken. For this presentation, the steroid response may be considered as a gradual elevation of intraocular pressure, occurring over several weeks, in an eye being medicated with corticosteroid drops several times a day. The elevation in pressure is usually accompanied by a reduction in the facility of aqueous outflow. When relatively large numbers of subjects were tested with topical steroids, so that a wide range of responsiveness could be observed, a variation in individual sensitivity was demonstrated. Frequency distributions of intraocular pressure or change in pressure following steroids showed a skew toward the high side. On the basis of trimodal characteristics which they observed in such frequency distributions, Becker and Hahn (1964), Becker (1965) and Armaly (1965, 1966) considered the possible existence of several genetically determined subpopulations. These investigators distinguished three subpopulations on the basis of low, intermediate, and high levels of pressure response. It was hypothesized that these levels of response characterized three phenotypes, corresponding to the three possible genotypes of an allele pair, wherein one member of the pair determined a low level of response, and the other member determined a high level of response (Armaly, 1967).

scholarly journals Vibration of Rotating and Revolving Planet Rings with Discrete and Partially Distributed Stiffnesses

2020 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Fuchun Yang ◽  
Dianrui Wang
Keyword(s):  
High Speed ◽  
Differential Operators ◽  
Natural Frequencies ◽  
Rotation Speed ◽  
Distribution Area ◽  
Vibration Modes ◽  
Governing Equations ◽  
Vibration Properties ◽  
Wide Range ◽  
Forced Responses

Vibration properties of high-speed rotating and revolving planet rings with discrete and partially distributed stiffnesses were studied. The governing equations were obtained by Hamilton’s principle based on a rotating frame on the ring. The governing equations were cast in matrix differential operators and discretized, using Galerkin’s method. The eigenvalue problem was dealt with state space matrix, and the natural frequencies and vibration modes were computed in a wide range of rotation speed. The properties of natural frequencies and vibration modes with rotation speed were studied for free planet rings and planet rings with discrete and partially distributed stiffnesses. The influences of several parameters on the vibration properties of planet rings were also investigated. Finally, the forced responses of planet rings resulted from the excitation of rotating and revolving movement were studied. The results show that the revolving movement not only affects the free vibration of planet rings but results in excitation to the rings. Partially distributed stiffness changes the vibration modes heavily compared to the free planet ring. Each vibration mode comprises several nodal diameter components instead of a single component for a free planet ring. The distribution area and the number of partially distributed stiffnesses mainly affect the high-order frequencies. The forced responses caused by revolving movement are nonlinear and vary with a quasi-period of rotating speed, and the responses in the regions supported by partially distributed stiffnesses are suppressed.

scholarly journals Towards a Glass New World: The Role of Ion-Exchange in Modern Technology

2021 ◽  
Vol 11 (10) ◽  
pp. 4610
Author(s):  
Simone Berneschi ◽  
Giancarlo C. Righini ◽  
Stefano Pelli
Keyword(s):  
Ion Exchange ◽  
Communication Networks ◽  
High Speed ◽  
High Performance ◽  
Low Cost ◽  
Modern Technology ◽  
Historical Background ◽  
Wide Range ◽  
Happy Marriage

Glasses, in their different forms and compositions, have special properties that are not found in other materials. The combination of transparency and hardness at room temperature, combined with a suitable mechanical strength and excellent chemical durability, makes this material indispensable for many applications in different technological fields (as, for instance, the optical fibres which constitute the physical carrier for high-speed communication networks as well as the transducer for a wide range of high-performance sensors). For its part, ion-exchange from molten salts is a well-established, low-cost technology capable of modifying the chemical-physical properties of glass. The synergy between ion-exchange and glass has always been a happy marriage, from its ancient historical background for the realisation of wonderful artefacts, to the discovery of novel and fascinating solutions for modern technology (e.g., integrated optics). Getting inspiration from some hot topics related to the application context of this technique, the goal of this critical review is to show how ion-exchange in glass, far from being an obsolete process, can still have an important impact in everyday life, both at a merely commercial level as well as at that of frontier research.

scholarly journals Prototype Design and Experimental Evaluation of Autonomous Collaborative Communication System for Emerging Maritime Use Cases

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3871
Author(s):  
Jiri Pokorny ◽  
Khanh Ma ◽  
Salwa Saafi ◽  
Jakub Frolka ◽  
Jose Villa ◽  
...  
Keyword(s):  
Communication System ◽  
Autonomous Vehicles ◽  
High Speed ◽  
High Capacity ◽  
Workplace Safety ◽  
Unmanned Vehicles ◽  
Use Cases ◽  
Automated Systems ◽  
Collaborative Communication ◽  
Wide Range

Automated systems have been seamlessly integrated into several industries as part of their industrial automation processes. Employing automated systems, such as autonomous vehicles, allows industries to increase productivity, benefit from a wide range of technologies and capabilities, and improve workplace safety. So far, most of the existing systems consider utilizing one type of autonomous vehicle. In this work, we propose a collaboration of different types of unmanned vehicles in maritime offshore scenarios. Providing high capacity, extended coverage, and better quality of services, autonomous collaborative systems can enable emerging maritime use cases, such as remote monitoring and navigation assistance. Motivated by these potential benefits, we propose the deployment of an Unmanned Surface Vehicle (USV) and an Unmanned Aerial Vehicle (UAV) in an autonomous collaborative communication system. Specifically, we design high-speed, directional communication links between a terrestrial control station and the two unmanned vehicles. Using measurement and simulation results, we evaluate the performance of the designed links in different communication scenarios and we show the benefits of employing multiple autonomous vehicles in the proposed communication system.

Ocular tissue changes associated with anterior segment opacity in lumpfish ( Cyclopterus lumpus L) eye

2019 ◽  
Vol 42 (10) ◽  
pp. 1401-1408
Author(s):  
Helene Paradis ◽  
Raahyma Ahmad ◽  
James McDonald ◽  
Danny Boyce ◽  
Robert L. Gendron
Keyword(s):  
Anterior Segment ◽  
Ocular Tissue ◽  
Cyclopterus Lumpus ◽  
Tissue Changes

scholarly journals Jet-Surface Interaction Test: Far-Field Noise Results

2013 ◽  
Vol 135 (7) ◽  
Author(s):  
Clifford A. Brown
Keyword(s):  
High Speed ◽  
Radial Distance ◽  
Jet Noise ◽  
Surface Interaction ◽  
Shielding Effect ◽  
Noise Prediction ◽  
Far Field ◽  
Wide Range ◽  
Field Noise ◽  
Surface Length

Many configurations proposed for the next generation of aircraft rely on the wing or other aircraft surfaces to shield the engine noise from the observers on the ground. However, the ability to predict the shielding effect and any new noise sources that arise from the high-speed jet flow interacting with a hard surface is currently limited. Furthermore, quality experimental data from jets with surfaces nearby suitable for developing and validating noise prediction methods are usually tied to a particular vehicle concept and, therefore, very complicated. The Jet-Surface Interaction Tests are intended to supply a high quality set of data covering a wide range of surface geometries and positions and jet flows to researchers developing aircraft noise prediction tools. The initial goal is to measure the noise of a jet near a simple planar surface while varying the surface length and location in order to: (1) validate noise prediction schemes when the surface is acting only as a jet noise shield and when the jet-surface interaction is creating additional noise, and (2) determine regions of interest for future, more detailed, tests. To meet these objectives, a flat plate was mounted on a two-axis traverse in two distinct configurations: (1) as a shield between the jet and the observer and (2) as a reflecting surface on the opposite side of the jet from the observer. The surface length was varied between 2 and 20 jet diameters downstream of the nozzle exit. Similarly, the radial distance from the jet centerline to the surface face was varied between 1 and 16 jet diameters. Far-field and phased array noise data were acquired at each combination of surface length and radial location using two nozzles operating at jet exit conditions across several flow regimes: subsonic cold, subsonic hot, underexpanded, ideally expanded, and overexpanded supersonic. The far-field noise results, discussed here, show where the jet noise is partially shielded by the surface and where jet-surface interaction noise dominates the low frequency spectrum as a surface extends downstream and approaches the jet plume.

Cost of Speed: Analysis of Capital Cost Estimates for High-Speed Ground Transportation Systems

1997 ◽  
Vol 1584 (1) ◽  
pp. 17-21
Author(s):  
John A. Harrison
Keyword(s):  
Los Angeles ◽  
High Speed ◽  
Capital Cost ◽  
Travel Times ◽  
Department Of Transportation ◽  
High Speed Rail ◽  
Cost Estimates ◽  
Capital Costs ◽  
Trip Time ◽  
Wide Range

The Intermodal Surface Transportation Efficiency Act of 1991 required the U.S. Department of Transportation to evaluate the commercial feasibility of high-speed ground transportation—a family of technologies ranging from incremental rail improvements to high-speed rail and magnetic levitation (Maglev) systems—in selected urban corridors. The evaluation involved estimating travel times, capital costs, operation and maintenance costs, and ridership for proposed service frequencies and then computing the potential return on investment from fares and other potential revenues. The results are documented in a U.S. Department of Transportation report generally referred to as the commercial feasibility study (CFS). Two elements of the CFS are addressed here: travel times and capital costs in four illustrative corridors—Chicago to St. Louis; Los Angeles to San Francisco; Eugene, Oreg., to Vancouver, B.C.; and Miami to Tampa via Orlando. Analysis of the results reveals common cost trends: for average speeds up to about 200 km/hr (125 mph), the initial investment required is generally in the range $1.6 to $3 million per route-kilometer ($2.6 to 4.8 million per route-mile). Above this speed regime (which varies by corridor), the initial investment increases steadily with speed, generally reaching $10 to $12 million per route-km ($16 to $19 million per route-mi) for very-high-speed rail systems and from $14 to $19 million per route-km ($23 to $31 million per route-mi) for Maglev systems. Analysis of the capital cost estimates reveals that despite the wide range of initial costs for the high-speed options, the cost per minute of trip time saved is remarkably consistent in corridors of similar length and with similar terrains. Cost-effectiveness plots are provided, allowing the reader to compare the performance of each of the four corridors in terms of trip time savings and cost per route-kilometer.

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