Effects of RRR-α-Tocopheryl Succinate on IL-1 and PGE2 Production by Avian Macrophages

1994 ◽  
pp. 230-230
Author(s):  
E. H. Romach ◽  
B. G. Sanders ◽  
K. Kline
Keyword(s):  
Pge2 Production ◽  
Tocopheryl Succinate

Effects of RRR‐α‐tocopheryl succinate on il‐1 and PGE2 production by macrophages

1993 ◽  
Vol 20 (3) ◽  
pp. 205-214 ◽  
Author(s):  
Elizabeth Huggins Romach ◽  
Sudha Kidao ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Pge2 Production ◽  
Tocopheryl Succinate

scholarly journals Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.

2021 ◽  
Vol 10 (10) ◽  
pp. 2100
Author(s):  
Hiroshi Sakagami ◽  
Sachie Nakatani ◽  
Ayame Enomoto ◽  
Sana Ota ◽  
Miku Kaneko ◽  
...  
Keyword(s):  
Culture Medium ◽  
Growth Stimulation ◽  
Pge2 Production ◽  
Oral Diseases ◽  
Total Glutathione ◽  
Simultaneous Treatment ◽  
Alkaline Extract ◽  
Omics Analysis ◽  
Anti Inflammatory ◽  
Inflammatory Action

Efficient utilization of alkaline extracts of several plants for the treatment of oral diseases has been reported. To investigate the mechanism of anti-inflammatory activity of alkaline extract of the leaves of Sasa sp. (SE), multi-omics analysis using metabolomics and DNA array was performed. Human gingival fibroblasts (HGFs) were treated for IL-1β to induce inflammation (detected by PGE2 production in culture medium) in the presence or absence of SE. Both IL-1β and SE showed slight hormetic growth stimulation against HGF. SE inhibited PGE2 production dose- and time-dependently. Its inhibitory action was more pronounced by first treating the cells with SE, rather than with IL-1β. At 3 h after IL-1β treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated. These changes were reversed by simultaneous treatment with SE. The present study suggests that the anti-inflammatory action of SE is mediated via various metabolic pathways for cell survival, apoptosis, and leukocyte recruitment.

scholarly journals Bone Marrow Mesenchymal Stromal Cells on Silk Fibroin Scaffolds to Attenuate Polymicrobial Sepsis Induced by Cecal Ligation and Puncture

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1433
Author(s):  
Ok-Hyeon Kim ◽  
Jun-Hyung Park ◽  
Jong-In Son ◽  
Ok-Ja Yoon ◽  
Hyun-Jung Lee
Keyword(s):  
Bone Marrow ◽  
Cecal Ligation ◽  
Biological Properties ◽  
Pge2 Production ◽  
Polymicrobial Sepsis ◽  
Control Surface ◽  
Related Factors ◽  
Cox 2 ◽  
Anti Inflammatory

Suitable scaffolds with appropriate mechanical and biological properties can improve mesenchymal stromal cell (MSC) therapy. Because silk fibroins (SFs) are biocompatible materials, they were electrospun and applied as scaffolds for MSC therapy. Consequently, interferon (IFN)-primed human bone marrow MSCs on SF nanofibers were administered into a polymicrobial sepsis murine model. The IL-6 level gradually decreased from 40 ng/mL at 6 h after sepsis to 35 ng/mL at 24 h after sepsis. The IL-6 level was significantly low as 5 ng/mL in primed MSCs on SF nanofibers, and 15 ng/mL in primed MSCs on the control surface. In contrast to the acute response, inflammation-related factors, including HO-1 and COX-2 in chronic liver tissue, were effectively inhibited by MSCs on both SF nanofibers and the control surface at the 5-day mark after sepsis. An in vitro study indicated that the anti-inflammatory function of MSCs on SF nanofibers was mediated through enhanced COX-2-PGE2 production, as indomethacin completely abrogated PGE2 production and decreased the survival rate of septic mice. Thus, SF nanofiber scaffolds potentiated the anti-inflammatory and immunomodulatory functions of MSCs, and were beneficial as a culture platform for the cell therapy of inflammatory disorders.

Effect of oxybenzone on PGE2-production in vitro and on plaque and gingivitis in vivo

2004 ◽  
Vol 31 (2) ◽  
pp. 91-94 ◽  
Author(s):  
Lillemor Jannesson ◽  
Dowen Birkhed ◽  
Dale Scherl ◽  
Abdul Gaffar ◽  
Stefan Renvert
Keyword(s):  
Pge2 Production

scholarly journals Immune Complex/Ig Negatively Regulate TLR4-Triggered Inflammatory Response in Macrophages through FcγRIIb-Dependent PGE2 Production

2008 ◽  
Vol 182 (1) ◽  
pp. 554-562 ◽  
Author(s):  
Yan Zhang ◽  
Shuxun Liu ◽  
Juan Liu ◽  
Ting Zhang ◽  
Qian Shen ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Immune Complex ◽  
Pge2 Production

Role of reactive oxygen species in the induction of apoptosis by ?-tocopheryl succinate

2004 ◽  
Vol 112 (3) ◽  
pp. 385-392 ◽  
Author(s):  
Young-Hwa Kang ◽  
Eunmyong Lee ◽  
Moon-Kyung Choi ◽  
Ja-Lok Ku ◽  
So Hee Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tocopheryl Succinate ◽  
Induction Of Apoptosis
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