Evidence-Based Medicine and Comparative Effectiveness Research

2015 ◽  
pp. 1-19
Author(s):  
M. Hassan Murad ◽  
Erik P. Hess ◽  
Victor M. Montori
Keyword(s):  
Comparative Effectiveness Research ◽  
Evidence Based Medicine ◽  
Comparative Effectiveness ◽  
Evidence Based ◽  
Effectiveness Research ◽  
Based Medicine

scholarly journals Comparative Effectiveness Research: Using Systematic Reviews and Meta-Analyses to Synthesize Empirical Evidence

2011 ◽  
Vol 25 (3) ◽  
pp. 191-209 ◽  
Author(s):  
Maria C. Katapodi ◽  
Laurel L. Northouse
Keyword(s):  
Systematic Reviews ◽  
Comparative Effectiveness Research ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Research Question ◽  
Alternative Methods ◽  
Evidence Based ◽  
Effectiveness Research ◽  
Meta Analyses ◽  
Research Studies

The increased demand for evidence-based health care practices calls for comparative effectiveness research (CER), namely the generation and synthesis of research evidence to compare the benefits and harms of alternative methods of care. A significant contribution of CER is the systematic identification and synthesis of available research studies on a specific topic. The purpose of this article is to provide an overview of methodological issues pertaining to systematic reviews and meta-analyses to be used by investigators with the purpose of conducting CER. A systematic review or meta-analysis is guided by a research protocol, which includes (a) the research question, (b) inclusion and exclusion criteria with respect to the target population and studies, © guidelines for obtaining relevant studies, (d) methods for data extraction and coding, (e) methods for data synthesis, and (f ) guidelines for reporting results and assessing for bias. This article presents an algorithm for generating evidence-based knowledge by systematically identifying, retrieving, and synthesizing large bodies of research studies. Recommendations for evaluating the strength of evidence, interpreting findings, and discussing clinical applicability are offered.

scholarly journals Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research

2017 ◽  
Vol 19 (10) ◽  
pp. 1081-1091 ◽  
Author(s):  
Kathryn A. Phillips ◽  
Patricia A. Deverka ◽  
Harold C. Sox ◽  
Muin J. Khoury ◽  
Lewis G. Sandy ◽  
...  
Keyword(s):  
Comparative Effectiveness Research ◽  
Comparative Effectiveness ◽  
Genomic Medicine ◽  
Landscape Analysis ◽  
Evidence Based ◽  
Effectiveness Research ◽  
Patient Centered

scholarly journals How the science of practice will improve evidence-based care

2020 ◽  
Vol 48 (5) ◽  
pp. E7
Author(s):  
Robert E. Harbaugh
Keyword(s):  
Quality Assurance ◽  
Comparative Effectiveness ◽  
Review Article ◽  
Evidence Based ◽  
Effectiveness Research ◽  
Causal Inferences ◽  
Present Evidence ◽  
Based Medicine ◽  
Evidence Based Care ◽  
Quality Improvement Tool

This review article analyzes the present evidence-based medicine (EBM) algorithm, compares it to the science of practice (SOP) algorithm, and demonstrates how the SOP can evolve from a quality assurance and quality improvement tool into a clinical research tool. Using appropriately constructed prospective observational databases (PODs), the SOP algorithm can be used to draw causal inferences from nonrandomized data, perform innovative comparative effectiveness research, and generate reliable information that can be used to guide treatment decisions.

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