Astroglial and Neuronal Integrity During Cortical Spreading Depolarization

Faculty Opinions recommendation of Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.722313649.793510614 ◽

2015 ◽

Author(s):

Peter Andrews

Keyword(s):

Subarachnoid Hemorrhage ◽

Cerebral Ischemia ◽

Delayed Cerebral Ischemia ◽

Spreading Depolarization ◽

Angiographic Vasospasm

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Cortical spreading depolarization and ketamine: a short systematic review

Neurophysiologie Clinique ◽

10.1016/j.neucli.2021.01.004 ◽

2021 ◽

Author(s):

João Paulo Mota Telles ◽

Leonardo Christiaan Welling ◽

Antonio Carlos Samaia da Silva Coelho ◽

Nícollas Nunes Rabelo ◽

Manoel Jacobsen Teixeira ◽

...

Keyword(s):

Systematic Review ◽

Spreading Depolarization

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Neuronal plumes initiate spreading depolarization, the electrophysiologic event driving migraine and stroke

Neuron ◽

10.1016/j.neuron.2021.01.024 ◽

2021 ◽

Vol 109 (4) ◽

pp. 563-565

Author(s):

Katharina Eikermann-Haerter

Keyword(s):

Spreading Depolarization

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Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice

Neurobiology of Disease ◽

10.1016/j.nbd.2021.105424 ◽

2021 ◽

pp. 105424

Author(s):

Anisa Dehghani ◽

Thas Phisonkunkasem ◽

Sinem Yilmaz Ozcan ◽

Turgay Dalkara ◽

Arn M.J.M. van den Maagdenberg ◽

...

Keyword(s):

Familial Hemiplegic Migraine ◽

Hemiplegic Migraine ◽

Spreading Depolarization ◽

Brain Parenchymal

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Neuronal pannexin-1 channels are not molecular routes of water influx during spreading depolarization-induced dendritic beading

Journal of Cerebral Blood Flow & Metabolism ◽

10.1177/0271678x16639328 ◽

2016 ◽

Vol 37 (5) ◽

pp. 1626-1633 ◽

Cited By ~ 7

Author(s):

Jeremy Sword ◽

Deborah Croom ◽

Phil L Wang ◽

Roger J Thompson ◽

Sergei A Kirov

Keyword(s):

Pyramidal Neurons ◽

Transport Mechanisms ◽

Coupled Transport ◽

Pannexin 1 ◽

Two Photon ◽

Spreading Depolarization ◽

Water Influx ◽

Membrane Bound ◽

Genetic Deletion

Spreading depolarization-induced focal dendritic swelling (beading) is an early hallmark of neuronal cytotoxic edema. Pyramidal neurons lack membrane-bound aquaporins posing a question of how water enters neurons during spreading depolarization. Recently, we have identified chloride-coupled transport mechanisms that can, at least in part, participate in dendritic beading. Yet transporter-mediated ion and water fluxes could be paralleled by water entry through additional pathways such as large-pore pannexin-1 channels opened by spreading depolarization. Using real-time in vivo two-photon imaging in mice with pharmacological inhibition or conditional genetic deletion of pannexin-1, we showed that pannexin-1 channels are not required for spreading depolarization-induced focal dendritic swelling.

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In Vivo Neocortical [K]o Modulation by Targeted Stimulation of Astrocytes

International Journal of Molecular Sciences ◽

10.3390/ijms22168658 ◽

2021 ◽

Vol 22 (16) ◽

pp. 8658

Author(s):

Azin EbrahimAmini ◽

Shanthini Mylvaganam ◽

Paolo Bazzigaluppi ◽

Mohamad Khazaei ◽

Alexander Velumian ◽

...

Keyword(s):

Nervous System ◽

Membrane Potential ◽

Potassium Ion ◽

Ion Concentration ◽

Extracellular Potassium ◽

Spreading Depolarization ◽

Potential Tool ◽

Stimulation Of

A normally functioning nervous system requires normal extracellular potassium ion concentration ([K]o). Throughout the nervous system, several processes, including those of an astrocytic nature, are involved in [K]o regulation. In this study we investigated the effect of astrocytic photostimulation on [K]o. We hypothesized that in vivo photostimulation of eNpHR-expressing astrocytes leads to a decreased [K]o. Using optogenetic and electrophysiological techniques we showed that stimulation of eNpHR-expressing astrocytes resulted in a significantly decreased resting [K]o and evoked K responses. The amplitude of the concomitant spreading depolarization-like events also decreased. Our results imply that astrocytic membrane potential modification could be a potential tool for adjusting the [K]o.

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