Assessment of Inflammasome Activation by Cytokine and Danger Signal Detection

2016 ◽  
pp. 63-74
Author(s):  
Nicolas Riteau ◽  
Aurélie Gombault ◽  
Isabelle Couillin
Keyword(s):  
Signal Detection ◽  
Inflammasome Activation ◽  
Danger Signal

scholarly journals Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

2015 ◽  
Vol 29 (9) ◽  
pp. 3899-3910 ◽  
Author(s):  
Hiroyuki Kadoya ◽  
Minoru Satoh ◽  
Tamaki Sasaki ◽  
Shun'ichiro Taniguchi ◽  
Masafumi Takahashi ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Inflammasome Activation ◽  
Danger Signal

scholarly journals Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

2011 ◽  
Vol 108 (5) ◽  
pp. 2088-2093 ◽  
Author(s):  
Anna E. Denoble ◽  
Kim M. Huffman ◽  
Thomas V. Stabler ◽  
Susan J. Kelly ◽  
Michael S. Hershfield ◽  
...  
Keyword(s):  
Uric Acid ◽  
Inflammasome Activation ◽  
Danger Signal ◽  
Increasing Risk

Inflammasome activation by danger signals: extracellular ATP and pH

Inflammasome ◽  
2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Takato Takenouchi ◽  
Mitsutoshi Tsukimoto ◽  
Makoto Hashimoto ◽  
Hiroshi Kitani
Keyword(s):  
P2x7 Receptor ◽  
Extracellular Atp ◽  
Innate Immune ◽  
Inflammasome Activation ◽  
Danger Signal ◽  
Interleukin 18 ◽  
Extracellular Acidification ◽  
Danger Signals ◽  
Acidic Extracellular Ph ◽  
Pro Inflammatory Cytokines

AbstractExtracellular ATP has been recognized as a danger signal that alerts the innate immune system. High extracellular concentrations of ATP can trigger the maturation and secretion of pro-inflammatory cytokines (e.g., interleukin-1β and interleukin-18) through the inflammasome-dependent activation of caspase-1. The P2X7 receptor, an ATP-gated cation channel, plays a pivotal role in ATP-induced NLRP3 inflammasome assembly. Recently, intriguing evidence has emerged that acidic extracellular pH acts as a danger signal that activates inflammasomes. Extracellular acidification frequently occurs at sites of inflammation, infection, or injury. In addition, large amounts of ATP are readily released into the extracellular space from damaged cells at such sites. Thus, it is assumed that the ATP/P2X7 receptor pathway regulates the inflammatory response under acidic extracellular conditions. Here, we briefly discuss the mutual effects of extracellular ATP and pH on inflammasome activation and consider their roles in the regulation of inflammation.

MPS 13-08 EXCESS ALDOSTERONE IS A CRITICAL DANGER SIGNAL FOR INFLAMMASOME ACTIVATION IN THE DEVELOPMENT OF RENAL FIBROSIS IN MICE

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e409-e410
Author(s):  
Minoru Satoh ◽  
Hiroyuki Kadoya ◽  
Tamaki Sasaki ◽  
Shun’ichiro Taniguchi ◽  
Masafumi Takahashi ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Inflammasome Activation ◽  
Danger Signal

Sample Size and the Detection of Correlation--A Signal Detection Account: Comment on Kareev (2000) and Juslin and Olsson (2005).

2005 ◽  
Vol 112 (1) ◽  
pp. 268-279 ◽  
Author(s):  
Richard B. Anderson ◽  
Michael E. Doherty ◽  
Neil D. Berg ◽  
Jeff C. Friedrich
Keyword(s):  
Signal Detection ◽  
Sample Size

So, Whatever Happened to Signal Detection Theory?

1995 ◽  
Vol 40 (10) ◽  
pp. 972-972
Author(s):  
Jerome R. Busemeyer
Keyword(s):  
Signal Detection ◽  
Signal Detection Theory ◽  
Detection Theory

Do logistic regression and signal detection identify different subgroups at risk? Implications for the design of tailored interventions.

2001 ◽  
Vol 6 (1) ◽  
pp. 35-48 ◽  
Author(s):  
Michaela Kiernan ◽  
Helena C. Kraemer ◽  
Marilyn A. Winkleby ◽  
Abby C. King ◽  
C. Barr Taylor
Keyword(s):  
At Risk ◽  
Logistic Regression ◽  
Signal Detection ◽  
Tailored Interventions
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