scholarly journals De Novo Transcriptomic Approach to Study Thyroid Hormone Receptor Action in Non-mammalian Models

2018 ◽  
pp. 265-285 ◽  
Author(s):  
Nicolas Buisine ◽  
Gwenneg Kerdivel ◽  
Laurent M. Sachs
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
De Novo ◽  
Receptor Action

scholarly journals AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.

1993 ◽  
Vol 268 (4) ◽  
pp. 2749-2754
Author(s):  
F.E. Wondisford ◽  
H.J. Steinfelder ◽  
M. Nations ◽  
S. Radovick
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Beta Subunit ◽  
Subunit Gene ◽  
Receptor Action ◽  
Beta Subunit Gene

scholarly journals A De Novo L330S Point Mutation in Thyroid Hormone Receptor Beta Gene in a Thai Female with Resistance to Thyroid Hormone.

1999 ◽  
Vol 46 (6) ◽  
pp. 825-829 ◽  
Author(s):  
SASITORN DITUDOMPO ◽  
BOONSONG ONGPHIPHADHANAKUL ◽  
SUWANNEE CHANPRASERTYOTIN ◽  
RAJATA RAJATANAVIN
Keyword(s):  
Thyroid Hormone ◽  
Point Mutation ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
De Novo ◽  
Resistance To Thyroid Hormone ◽  
Beta Gene ◽  
Receptor Beta

A novel de novo mutation in the thyroid hormone receptor-beta gene

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
A Chatzitomaris ◽  
R Köditz ◽  
W Höppner ◽  
S Peters ◽  
HH Klein ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
De Novo ◽  
De Novo Mutation ◽  
Beta Gene ◽  
Receptor Beta

Identification and characterization of a novel de novo mutation (L346V) in the thyroid hormone receptor beta gene in a family with generalized thyroid hormone resistance

1997 ◽  
pp. 370-376 ◽  
Author(s):  
E Macchia ◽  
M Gurnell ◽  
M Agostini ◽  
G Giorgilli ◽  
C Marcocci ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
De Novo ◽  
Index Case ◽  
Family Members ◽  
Elevated Serum ◽  
De Novo Mutation ◽  
Beta Gene ◽  
Receptor Beta

We have investigated an Italian family with generalized resistance to thyroid hormone (RTH), consisting of two individuals with elevated serum thyroid hormones (TH) and a non-suppressed TSH, together with unaffected family members, for a mutation in the thyroid hormone receptor beta gene (hTR beta). We have identified a single nucleotide substitution (1321 CTT to GTT) corresponding to a leucine to valine substitution at codon 346 (L346V) in the predicted protein. The index case and her affected child are heterozygous for the receptor defect, with normal sequence in unaffected family members. Furthermore, both parents of the index case were unaffected, suggesting that the mutation had arisen de novo. When expressed in vitro, the L346V mutant receptor showed a marked reduction in its affinity for tri-iodothyronine (T3), impaired ligand-dependent transactivation and potent dominant negative activity. Its functional impairment could not be alleviated, even at supraphysiological concentrations of T3, suggesting that the mutation might interfere with the intrinsic ligand-dependent transactivation function (AF-2) located in the hormone binding domain of hTR beta. Finally, the presence of the L346V mutation in the son of the propositus, who died from complications associated with congenital heart disease, raises the possibility that RTH might have contributed to the pathogenesis or severity of the latter.

Mechanisms of thyroid hormone receptor action during development: Lessons from amphibian studies

2013 ◽  
Vol 1830 (7) ◽  
pp. 3882-3892 ◽  
Author(s):  
Alexis Grimaldi ◽  
Nicolas Buisine ◽  
Thomas Miller ◽  
Yun-Bo Shi ◽  
Laurent M. Sachs
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Action

scholarly journals Interleukin-1β modulates endogenous thyroid hormone receptor α gene transcription in liver cells

2007 ◽  
Vol 194 (2) ◽  
pp. 257-265 ◽  
Author(s):  
J Kwakkel ◽  
W M Wiersinga ◽  
A Boelen
Keyword(s):  
Thyroid Hormone ◽  
Mrna Expression ◽  
Gene Transcription ◽  
Hormone Receptor ◽  
Proinflammatory Cytokine ◽  
Hepg2 Cells ◽  
Promoter Activity ◽  
Thyroid Hormone Receptor ◽  
De Novo ◽  
Hepatoma Cells

One of the main characteristics of nonthyroidal illness (NTI) is a decrease in serum triiodothyronine, partly caused by a decrease in liver deiodinase type 1 (D1) mRNA and activity. Proinflammatory cytokines have been associated with NTI in view of their capability to decrease D1 and thyroid hormone receptor (TR)β1 mRNA expression in hepatoma cells. Proinflammatory cytokine induction leads to activation of the inflammatory pathways nuclear factor (NF)κB and activator protein (AP)-1. The proinflammatory cytokine interleukin (IL)-1β decreases thyroid hormone receptor (TR)β1 mRNA in an NFκB-dependent way. The aim of this study was to unravel the effects of IL-1β on endogenous TRα gene expression in an animal model and in a liver cell line. The TRα gene product is alternatively spliced in TRα1 and TRα2, TRα2 is capable of inhibiting TRα1-induced gene transcription. We showed that both TRα1 and TRα2 mRNA decreased not only after lipopolysaccharide administration in liver of mice, but also after IL-1β stimulation of hepatoma cells (HepG2). Using the NFκB inhibitor sulfasalazine and the AP-1 inhibitor SP600125, it became clear that the IL-1β-induced decrease in TRα mRNA expression in HepG2 cells can only be abolished by simultaneous inhibition of NFκB and AP-1. The IL-1β-induced TRα1 and TRα2 mRNA decrease in HepG2 cells is the result of decreased TRα gene promoter activity, as evident from actinomycin D experiments. Cycloheximide experiments showed that the decreased promoter activity is independent of de novo protein synthesis and therefore most likely due to posttranslational modifications such as phosphorylation or subcellular relocalization.

scholarly journals General Receptor for Phosphoinositides 1, a Novel Repressor of Thyroid Hormone Receptor Action that Prevents Deoxyribonucleic Acid Binding

2005 ◽  
Vol 19 (8) ◽  
pp. 1991-2005 ◽  
Author(s):  
Marie-Belle Poirier ◽  
Genevieve Hamann ◽  
Marie-Eve Domingue ◽  
Melanie Roy ◽  
Tayna Bardati ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Deoxyribonucleic Acid ◽  
Thyroid Hormone Receptor ◽  
Receptor Action
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