Ca2+-Binding Proteins of the EF-Hand Superfamily: Diagnostic and Prognostic Biomarkers and Novel Therapeutic Targets

2019 ◽  
pp. 157-186 ◽  
Author(s):  
Claus W. Heizmann
Keyword(s):  
Binding Proteins ◽  
Therapeutic Targets ◽  
Prognostic Biomarkers ◽  
Ef Hand ◽  
Novel Therapeutic

Identification of Therapeutic Targets and Prognostic Biomarkers of IGF2BPs in the Lung Cancer Microenvironment

2021 ◽  
Author(s):  
Xuanzheng Wang ◽  
Weina Kong ◽  
Fan Guo ◽  
Ruocheng Sha ◽  
Gang Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Binding Proteins ◽  
Rna Binding ◽  
Therapeutic Targets ◽  
Prognostic Biomarkers ◽  
Lung Cancer Patients ◽  
Cancer Tissues

Abstract Background: Lung cancer is one of the most common malignances with an ever-increasing incidence and high mortality. The insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as RNA-binding proteins play an important role in messenger RNA (mRNA) regulation during tumor development. Even so, the expression and prognostic values of IGF2BPs in lung cancer have not been clarified.Main methods: To address this issue, the study investigated the roles of IGF2BPs in the prognosis of lung cancer by using public databases and quantitative real-time PCR (Q-PCR).Results: The transcriptional levels of IGF2BP1/2/3 in lung cancer tissues were significantly elevated, associating with pathological stages and poor prognosis of overall survival (OS) and progression-free survival (FP) in lung cancer patients. A high mutation rate of IGF2BPs (24%) was also observed of patients with lung cancer. The functions of differentially expressed IGF2BPs are primarily related to the spliceosome, hippo signaling pathway and transcriptional misregulation in cancer. Finally, we found significant correlations among the expression of IGF2BPs and the infiltration of six types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells).Conclusions: The results indicated that high mRNA expression of IGF2BP1/2/3 was found in lung cancer tissues, significantly associating with tumor grades and poor prognosis of OS and FP. Our results may provide insights for the selection of therapeutic targets and prognostic biomarkers for lung cancer patients.

scholarly journals Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets

2017 ◽  
Vol 23 (9) ◽  
pp. 2143-2153 ◽  
Author(s):  
Alexander E. Kudinov ◽  
John Karanicolas ◽  
Erica A. Golemis ◽  
Yanis Boumber
Keyword(s):  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Therapeutic Targets ◽  
Cancer Drivers ◽  
Novel Therapeutic

Identification of novel therapeutic targets in SDH-mutated cancers: tracing dysfunction

2017 ◽  
Author(s):  
Charlotte Lussey-Lepoutre ◽  
Kate E R Hollinshead ◽  
Christian Ludwig ◽  
Melanie Menara ◽  
Aurelie Morin ◽  
...  
Keyword(s):  
Therapeutic Targets ◽  
Novel Therapeutic

Novel Therapeutic Targets for Chronic Migraine

2012 ◽  
Author(s):  
Andrew Charles ◽  
Peter Goadsby
Keyword(s):  
Chronic Migraine ◽  
Therapeutic Targets ◽  
Novel Therapeutic

Oxidized Haemoglobin–Driven Endothelial Dysfunction and Immune Cell Activation: Novel Therapeutic Targets for Atherosclerosis

2013 ◽  
Vol 20 (37) ◽  
pp. 4806-4814 ◽  
Author(s):  
Brigitta Buttari ◽  
Elisabetta Profumo ◽  
Rita Businaro ◽  
Luciano Saso ◽  
Raffaele Capoano ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Immune Cell ◽  
Therapeutic Targets ◽  
Immune Cell Activation ◽  
Novel Therapeutic

Recent Development in Identification of Potential Novel Therapeutic Targets Against Trypanosomatids

2016 ◽  
Vol 16 (20) ◽  
pp. 2303-2315 ◽  
Author(s):  
Rajender Kumar ◽  
Parvati Sharma ◽  
Deepak Kumar Gaur ◽  
Shikha Jain
Keyword(s):  
Therapeutic Targets ◽  
Novel Therapeutic
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