scholarly journals Assessment of Young and Aged Hematopoietic Stem Cell Activity by Competitive Serial Transplantation Assays

2019 ◽  
pp. 193-203
Author(s):  
Yu Wei Zhang ◽  
Nina Cabezas-Wallscheid
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Activity ◽  
Hematopoietic Stem ◽  
Stem Cell Activity ◽  
Serial Transplantation

Protection of telomeres 1 (Pot1) regulates hematopoietic stem cell activity during ageing

2015 ◽  
Vol 43 (9) ◽  
pp. S68
Author(s):  
Kentaro Hosokawa ◽  
Ben D. MacArthur ◽  
Shigemasa Hanazawa ◽  
Toshio Suda ◽  
Fumio Arai
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Activity ◽  
Hematopoietic Stem ◽  
Stem Cell Activity ◽  
Protection Of Telomeres 1

scholarly journals Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

2008 ◽  
Vol 105 (30) ◽  
pp. 10396-10401 ◽  
Author(s):  
M. Ohtsubo ◽  
S. Yasunaga ◽  
Y. Ohno ◽  
M. Tsumura ◽  
S. Okada ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Ubiquitin Ligase ◽  
Cell Activity ◽  
E3 Ubiquitin Ligase ◽  
Polycomb Group ◽  
Hematopoietic Stem ◽  
Stem Cell Activity

Role for notch/RBPj in preserving hematopoietic stem cell activity

2013 ◽  
Vol 41 (8) ◽  
pp. S33
Author(s):  
Cristina Ruiz-Herguido ◽  
Lluis Espinosa ◽  
Anna Bigas
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Activity ◽  
Hematopoietic Stem ◽  
Stem Cell Activity

scholarly journals Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6

2008 ◽  
Vol 87 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Natsumi Shimizu ◽  
Shinichi Noda ◽  
Kazufumi Katayama ◽  
Hitoshi Ichikawa ◽  
Hiroaki Kodama ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Line ◽  
Hematopoietic Stem Cell ◽  
Stromal Cell ◽  
Cell Activity ◽  
Hematopoietic Stem ◽  
Stem Cell Activity ◽  
Stromal Cell Line

scholarly journals The GNAS R201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity

2018 ◽  
Vol 57 ◽  
pp. 14-20 ◽  
Author(s):  
Elizabeth L. Ostrander ◽  
Won Kyun Koh ◽  
Cates Mallaney ◽  
Ashley C. Kramer ◽  
W. Casey Wilson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Activity ◽  
Hematopoietic Stem ◽  
Clonal Hematopoiesis ◽  
Stem Cell Activity

scholarly journals Phenotypic analysis of mouse hematopoietic stem cells shows a Thy-1- negative subset

Blood ◽  
1992 ◽  
Vol 80 (8) ◽  
pp. 1957-1964 ◽  
Author(s):  
GJ Spangrude ◽  
DM Brooks
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Cells ◽  
Cell Activity ◽  
Mouse Strains ◽  
Hematopoietic Stem ◽  
Stem Cell Activity

Mouse hematopoietic stem cells can be identified and enriched from populations of normal bone marrow cells by immunofluorescent labeling of cell surface molecules followed by flow cytometric separation. We show here that the majority of hematopoietic stem cell activity, as defined by long-term competitive repopulation of irradiated animals and by a secondary transplant assay for spleen colony-forming units (CFU- S), could be localized in Ly-6b haplotype mice to a fraction of bone marrow cells that expresses the Ly-6A/E (Sca-1) molecule. Further, an analysis of hematopoietic stem cell activity in bone marrow of mouse strains expressing the Thy-1.1 allele indicated that the vast majority of activity was included in the Thy-1low population. In contrast, hematopoietic stem cell activity found in the bone marrow of Thy-1.2 genotype mouse strains was recovered in both the Thy-1neg and the Thy- 1low populations. However, similar to Thy-1.1 strains, most activity was localized to the Ly-6A/E+ population of cells. The difference in Thy-1 phenotype of hematopoietic stem cell activity apparent between Thy-1.1- and Thy-1.2-expressing mouse strains was not caused by differences in the staining intensity of monoclonal antibodies (MoAbs) specific for the Thy-1 alleles. Furthermore, an antiframework MoAb that stains both alleles of Thy-1 separated hematopoietic stem cell activity from mice expressing the two alleles in the same manner as did allele- specific MoAb. The results of this study show that Thy-1 expression is not an invariant characteristic of mouse hematopoietic stem cells, and that mice expressing the Thy-1.1 allele are unique in that hematopoietic stem cell activity is found exclusively in the Thy-1low population.

scholarly journals Glycogen Synthase Kinase-3β Inhibition Preserves Hematopoietic Stem Cell Activity and Inhibits Leukemic Cell Growth

Stem Cells ◽  
2008 ◽  
Vol 26 (5) ◽  
pp. 1288-1297 ◽  
Author(s):  
Tiffany Holmes ◽  
Tracey A. O'Brien ◽  
Robert Knight ◽  
Robert Lindeman ◽  
Sylvie Shen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Growth ◽  
Hematopoietic Stem Cell ◽  
Glycogen Synthase ◽  
Cell Activity ◽  
Leukemic Cell ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Hematopoietic Stem ◽  
Stem Cell Activity
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