Hematopoietic Growth Factors in Clinical Practice

2001 ◽  
pp. 371-377
Author(s):  
Pierre Noël
Keyword(s):  
Clinical Practice ◽  
Growth Factors ◽  
Hematopoietic Growth Factors

Consensus on the use of neutrophil-stimulating hematopoietic growth factors in clinical practice: an international viewpoint

1997 ◽  
Vol 8 (4) ◽  
pp. 263-275 ◽  
Author(s):  
James J Rusthoven ◽  
Elisabeth G.E de Vries ◽  
David C Dale ◽  
Martine Piccart ◽  
John Glaspy ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Growth Factors ◽  
Hematopoietic Growth Factors

Effect of hematopoietic growth factors on MR images of bone marrow in children undergoing chemotherapy.

Radiology ◽  
1993 ◽  
Vol 189 (3) ◽  
pp. 745-751 ◽  
Author(s):  
B D Fletcher ◽  
J E Wall ◽  
S L Hanna
Keyword(s):  
Bone Marrow ◽  
Growth Factors ◽  
Mr Images ◽  
Hematopoietic Growth Factors

Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging

1996 ◽  
Vol 31 (1-2) ◽  
pp. 135-144 ◽  
Author(s):  
J.P. Buchanan ◽  
C.A. Peters ◽  
C.J. Rasmussen ◽  
G. Rothstein
Keyword(s):  
Growth Factors ◽  
Hematopoietic Growth Factors

scholarly journals Ex vivo expansion of human hematopoietic stem and progenitor cells

Blood ◽  
2011 ◽  
Vol 117 (23) ◽  
pp. 6083-6090 ◽  
Author(s):  
Ann Dahlberg ◽  
Colleen Delaney ◽  
Irwin D. Bernstein
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Notch Signaling ◽  
Progenitor Cells ◽  
Ex Vivo ◽  
Ex Vivo Expansion ◽  
Hematopoietic Growth Factors ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells

AbstractDespite progress in our understanding of the growth factors that support the progressive maturation of the various cell lineages of the hematopoietic system, less is known about factors that govern the self-renewal of hematopoietic stem and progenitor cells (HSPCs), and our ability to expand human HSPC numbers ex vivo remains limited. Interest in stem cell expansion has been heightened by the increasing importance of HSCs in the treatment of both malignant and nonmalignant diseases, as well as their use in gene therapy. To date, most attempts to ex vivo expand HSPCs have used hematopoietic growth factors but have not achieved clinically relevant effects. More recent approaches, including our studies in which activation of the Notch signaling pathway has enabled a clinically relevant ex vivo expansion of HSPCs, have led to renewed interest in this arena. Here we briefly review early attempts at ex vivo expansion by cytokine stimulation followed by an examination of our studies investigating the role of Notch signaling in HSPC self-renewal. We will also review other recently developed approaches for ex vivo expansion, primarily focused on the more extensively studied cord blood–derived stem cell. Finally, we discuss some of the challenges still facing this field.

Hematopoietic Growth Factors in Pediatric Patients

2009 ◽  
Vol 30 (1) ◽  
pp. 30-31
Author(s):  
Peter D. Cole
Keyword(s):  
Growth Factors ◽  
Pediatric Patients ◽  
Hematopoietic Growth Factors
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