Interferons and Interleukin-2: Molecular Basis of Activity and Therapeutic Results

2009 ◽  
pp. 49-78
Author(s):  
Thomas E. Hutson ◽  
Snehal Thakkar ◽  
Peter Cohen ◽  
Ernest C. Borden
Keyword(s):  
Molecular Basis ◽  
Interleukin 2 ◽  
Therapeutic Results

scholarly journals Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model.

1986 ◽  
Vol 83 (23) ◽  
pp. 9026-9029 ◽  
Author(s):  
S. Kondo ◽  
A. Shimizu ◽  
Y. Saito ◽  
M. Kinoshita ◽  
T. Honjo
Keyword(s):  
Molecular Basis ◽  
Interleukin 2 ◽  
Receptor Affinity ◽  
Conversion Model ◽  
Interleukin 2 Receptor

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

Cytokine ◽  
2000 ◽  
Vol 12 (5) ◽  
pp. 477-482 ◽  
Author(s):  
Patricia L Podolin ◽  
Mary Beth Wilusz ◽  
Rose M Cubbon ◽  
Utpal Pajvani ◽  
Christopher J Lord ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Molecular Basis ◽  
Interleukin 2 ◽  
Diabetes Gene

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

Androgen-induced plasticity at a “vocal” neuromuscular synapse

1994 ◽  
Vol 52 ◽  
pp. 32-33
Author(s):  
Darcy B. Kelley ◽  
Martha L. Tobias ◽  
Mark Ellisman
Keyword(s):  
Xenopus Laevis ◽  
Motor Neurons ◽  
Sexual Differentiation ◽  
Molecular Basis ◽  
Neuromuscular Synapse ◽  
Sexually Dimorphic ◽  
Intracellular Protein ◽  
Developmental Program ◽  
Androgen Action ◽  
Clawed Frog

Brain and muscle are sexually differentiated tissues in which masculinization is controlled by the secretion of androgens from the testes. Sensitivity to androgen is conferred by the expression of an intracellular protein, the androgen receptor. A central problem of sexual differentiation is thus to understand the cellular and molecular basis of androgen action. We do not understand how hormone occupancy of a receptor translates into an alteration in the developmental program of the target cell. Our studies on sexual differentiation of brain and muscle in Xenopus laevis are designed to explore the molecular basis of androgen induced sexual differentiation by examining how this hormone controls the masculinization of brain and muscle targets.Our approach to this problem has focused on a highly androgen sensitive, sexually dimorphic neuromuscular system: laryngeal muscles and motor neurons of the clawed frog, Xenopus laevis. We have been studying sex differences at a synapse, the laryngeal neuromuscular junction, which mediates sexually dimorphic vocal behavior in Xenopus laevis frogs.

A molecular basis for opiate action

1998 ◽  
Vol 33 ◽  
pp. 65-77 ◽  
Author(s):  
Dominique Massotte ◽  
Brigitte L. Kieffer
Keyword(s):  
Molecular Basis
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