2D-DIGE: Comparative Proteomics of Cellular Signalling Pathways

2009 ◽  
pp. 105-132 ◽  
Author(s):  
Nadia Ben Larbi ◽  
Caroline Jefferies
Keyword(s):  
Comparative Proteomics ◽  
Signalling Pathways ◽  
2D Dige ◽  
Cellular Signalling ◽  
Cellular Signalling Pathways

scholarly journals CELLULAR SIGNALLING PATHWAYS: NEW TARGETS IN LEUKAEMIA THERAPY

2002 ◽  
Vol 116 (1) ◽  
pp. 57-77 ◽  
Author(s):  
Farhad Ravandi ◽  
Moshe Talpaz ◽  
Hagop Kantarjian ◽  
Zeev Estrov
Keyword(s):  
Signalling Pathways ◽  
New Targets ◽  
Cellular Signalling ◽  
Leukaemia Therapy ◽  
Cellular Signalling Pathways

Differential functions of tissue factor in the trans-activation of cellular signalling pathways

2007 ◽  
Vol 194 (1) ◽  
pp. 88-101 ◽  
Author(s):  
Camille Ettelaie ◽  
Chao Li ◽  
Mary E.W. Collier ◽  
Amandine Pradier ◽  
G. Alkistis Frentzou ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Signalling Pathways ◽  
Cellular Signalling ◽  
Cellular Signalling Pathways

scholarly journals Cellular signalling and the complexity of biological timing: insights from the ultradian clock of Schizosaccharomyces pombe

2001 ◽  
Vol 356 (1415) ◽  
pp. 1725-1733 ◽  
Author(s):  
Fred Kippert
Keyword(s):  
Protein Kinase ◽  
Schizosaccharomyces Pombe ◽  
Model Organism ◽  
Circadian Clocks ◽  
Mitogen Activated Protein Kinase ◽  
Signalling Pathways ◽  
Cellular Signalling ◽  
Short Period ◽  
Mitogen Activated Protein ◽  
Cellular Signalling Pathways

The molecular bases of circadian clocks are complex and cannot be sufficiently explained by the relatively simple feedback loops, based on transcription and translation, of current models. The existence of additional oscillators has been demonstrated experimentally, but their mechanism(s) have so far resisted elucidation and any universally conserved clock components have yet to be identified. The fission yeast, Schizosaccharomyces pombe , as a simple and well–characterized eukaryote, is a useful model organism in the investigation of many aspects of cell regulation. In fast–growing cells of the yeast an ultradian clock operates, which can serve as a model system to analyse clock complexity. This clock shares strict period homeostasis and efficient entrainment with circadian clocks but, because of its short period of 30 min, mechanisms other than a transcription/translation–based feedback loop must be working. An initial systematic screen involving over 200 deletion mutants has shown that major cellular signalling pathways (calcium/phosphoinositide, mitogen–activated protein kinase and cAMP/protein kinase A) are crucial for the normal functioning of this ultradian clock. A comparative examination of the role of cellular signalling pathways in the S.pombe ultradian clock and in the circadian timekeeping of different eukaryotes may indicate common principles in biological timing processes that are universally conserved amongst eukaryotes.

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

Nature ◽  
1987 ◽  
Vol 327 (6117) ◽  
pp. 67-70 ◽  
Author(s):  
Takaaki Yoshimasa ◽  
David R. Sibley ◽  
Michel Bouvier ◽  
Robert J. Lefkowitz ◽  
Marc G. Caron
Keyword(s):  
Adenylate Cyclase ◽  
Phorbol Ester ◽  
Cross Talk ◽  
Signalling Pathways ◽  
Cellular Signalling ◽  
Cellular Signalling Pathways
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