Therapeutic Strategies Employing Endogenous Neural Stem Cells in Tissue Remodeling Following Ischemic Injury

2007 ◽  
pp. 115-132
Author(s):  
Mark F. Mehler
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Tissue Remodeling ◽  
Ischemic Injury ◽  
Therapeutic Strategies ◽  
Endogenous Neural Stem Cells

scholarly journals Endogenous neural stem cells modulate microglia and protect against demyelination

2021 ◽  
Author(s):  
Béatrice Brousse ◽  
Océane Mercier ◽  
Karine Magalon ◽  
Fabrice Daian ◽  
Pascale Durbec ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

Activation of endogenous neural stem cells after traumatic brain injury

The Lancet ◽  
2014 ◽  
Vol 383 ◽  
pp. S18 ◽  
Author(s):  
Aminul Ahmed ◽  
Anan Shtaya ◽  
Malik Zaben ◽  
William Gray
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

Stem Cell Studies in Traumatic Brain Injury

Neurotrauma ◽  
2018 ◽  
pp. 373-386
Author(s):  
Dong Sun
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Cell Transplantation ◽  
Survival Rates ◽  
Structural Repair ◽  
Potential Strategy ◽  
Endogenous Neural Stem Cells

Traumatic brain injury (TBI) is a global public health concern, with limited treatment options available. Despite improving survival rates after TBI, there is no effective treatment to improve the neural structural repair and functional recovery of patients. Neural regeneration through neural stem cells, either by stimulating endogenous neural stem cells or by stem cell transplantation, has gained increasing attention as a potential strategy to repair and regenerate the injured brain. This chapter summarizes strategies that have been explored to enhance endogenous neural stem cells-mediated regeneration and recent developments in cell transplantation studies for post-TBI brain repair with varying types of cell sources.

scholarly journals Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice

2005 ◽  
Vol 102 (50) ◽  
pp. 18171-18176 ◽  
Author(s):  
J. R. Munoz ◽  
B. R. Stoutenger ◽  
A. P. Robinson ◽  
J. L. Spees ◽  
D. J. Prockop
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Neural Stem Cells ◽  
Progenitor Cells ◽  
Endogenous Neural Stem Cells

scholarly journals Dynamic Modelling of Interactions between Microglia and Endogenous Neural Stem Cells in the Brain during a Stroke

Mathematics ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 132 ◽  
Author(s):  
Awatif Jahman Alqarni ◽  
Azmin Sham Rambely ◽  
Ishak Hashim
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dynamic Modelling ◽  
Dynamic Effect ◽  
Brain Cells ◽  
Activated Microglia ◽  
Model Studies ◽  
The Impact ◽  
The Brain ◽  
Endogenous Neural Stem Cells

In this paper, we study the interactions between microglia and neural stem cells and the impact of these interactions on the brain cells during a stroke. Microglia cells, neural stem cells, the damage on brain cells from the stroke and the impacts these interactions have on living brain cells are considered in the design of mathematical models. The models consist of ordinary differential equations describing the effects of microglia on brain cells and the interactions between microglia and neural stem cells in the case of a stroke. Variables considered include: resident microglia, classically activated microglia, alternatively activated microglia, neural stem cells, tissue damage on cells in the brain, and the impacts these interactions have on living brain cells. The first model describes what happens in the brain at the stroke onset during the first three days without the generation of any neural stem cells. The second model studies the dynamic effect of microglia and neural stem cells on the brain cells following the generation of neural stem cells and potential recovery after this stage. We look at the stability and the instability of the models which are both studied analytically. The results show that the immune cells can help the brain by cleaning dead cells and stimulating the generation of neural stem cells; however, excessive activation may cause damage and affect the injured region. Microglia have beneficial and harmful functions after ischemic stroke. The microglia stimulate neural stem cells to generate new cells that substitute dead cells during the recovery stage but sometimes the endogenous neural stem cells are highly sensitive to inflammatory in the brain.

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