Intravascular Characterization of Vulnerable Coronary Plaque

2010 ◽  
pp. 461-473
Author(s):  
James A. Goldstein ◽  
James E. Muller
Keyword(s):  
2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Zhonghua Sun ◽  
Lei Xu

Coronary computed tomography angiography (CCTA) has been recently evaluated for its ability to assess coronary plaque characteristics, including plaque composition. Identification of the relationship between plaque composition by CCTA and patient clinical presentations may provide insight into the pathophysiology of coronary artery plaque, thus assisting identification of vulnerable plaques which are associated with the development of acute coronary syndrome. CCTA-generated 3D visualizations allow evaluation of both coronary lesions and lumen changes, which are considered to enhance the diagnostic performance of CCTA. The purpose of this review is to discuss the recent developments that have occurred in the field of CCTA with regard to its diagnostic accuracy in the quantitative assessment of coronary plaques, with a focus on the characterization of plaque components and identification of vulnerable plaques.


2004 ◽  
Vol 23 (3) ◽  
pp. 201-211 ◽  
Author(s):  
Mauro Panteghini

This article reviews the current contribution of the determination of biochemical markers to clinical cardiology and discusses some important developments in this field. Biochemical markers play a pivotal role in the diagnosis and management of patients with acute coronary syndrome (ACS), as witnessed by the incorporation of cardiac troponins into new international guidelines for patients with ACS and in the redefinition of myocardial infarction. Despite the success of cardiac troponins, there is still a need for development of early markers that can reliably rule out ACS from the emergency room at presentation and detect myocardial ischemia also in the absence of irreversible myocyte injury. Under investigation are two classes of indicators: markers of early injury/ischemia and markers of coronary plaque instability and disruption. Finally, with the characterization of the cardiac natriuretic peptides, Laboratory Medicine is also assuming part in the assessment of cardiac function.


2013 ◽  
Vol 25 (5) ◽  
pp. 973-982 ◽  
Author(s):  
Eiji Uchino ◽  
Takanori Koga ◽  
Hideaki Misawa ◽  
Noriaki Suetake

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