Cerebral Hypoxia—Ischemia Model in Adult Mice

2009 ◽  
pp. 207-217
Author(s):  
Faisal Adhami ◽  
Chia-Yi Kuan
Keyword(s):  
Cerebral Hypoxia ◽  
Adult Mice ◽  
Hypoxia Ischemia

scholarly journals The Impact of Ly6Clow Monocytes after Cerebral Hypoxia-Ischemia in Adult Mice

2014 ◽  
Vol 34 (7) ◽  
pp. e1-e9 ◽  
Author(s):  
Jean-Philippe Michaud ◽  
Pedro Moreno Pimentel-Coelho ◽  
Yannick Tremblay ◽  
Serge Rivest
Keyword(s):  
Ischemic Stroke ◽  
Cell Loss ◽  
Cerebral Hypoxia ◽  
Lesion Site ◽  
Phagocytic Cells ◽  
Inflammatory Monocytes ◽  
Adult Mice ◽  
Hypoxia Ischemia ◽  
The Impact ◽  
Patrolling Monocytes

After an ischemic stroke, mononuclear phagocytic cells such as microglia, macrophages, and monocytes migrate to the lesion site and coordinate an immune response. Monocytes, which are recruited from the bloodstream after ischemic brain injury, can be categorized into two subsets in mice: inflammatory and patrolling monocytes. Although inflammatory monocytes (Ly6Chi) seem to have a protective role in stroke progression, the impact of patrolling monocytes (Ly6Clow) is unknown. To address the role of Ly6Clow monocytes in stroke, we generated bone marrow chimeric mice in which their hematopoietic system was replaced by Nr4a1−/− cells, allowing the complete and permanent ablation of Ly6Clow monocytes without affecting the Ly6Chi subset. We then subjected adult mice to cerebral hypoxia-ischemia using the Levine/Vannucci model. Functional outcomes after stroke such as body weight change, neurologic score, motor functions and spatial learning were not affected. Moreover, depletion in Ly6Clow monocytes did not change significantly the total infarct size, cell loss, atrophy, the number, or the activation state of microglia/macrophages at the lesion site. These data suggest that Ly6Clow patrolling monocytes are redundant in the progression and recovery of ischemic stroke.

scholarly journals Therapeutic Benefits of Delayed Lithium Administration in the Neonatal Rat after Cerebral Hypoxia-Ischemia

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107192 ◽  
Author(s):  
Cuicui Xie ◽  
Kai Zhou ◽  
Xiaoyang Wang ◽  
Klas Blomgren ◽  
Changlian Zhu
Keyword(s):  
Neonatal Rat ◽  
Cerebral Hypoxia ◽  
Therapeutic Benefits ◽  
Hypoxia Ischemia

Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain

2007 ◽  
Vol 412 (2) ◽  
pp. 114-117 ◽  
Author(s):  
John C. Ashton ◽  
Rosanna M.A. Rahman ◽  
Shiva M. Nair ◽  
Brad A. Sutherland ◽  
Michelle Glass ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Cerebral Hypoxia ◽  
Cb2 Receptor ◽  
Hypoxia Ischemia ◽  
Cerebral Artery Occlusion ◽  
The Brain

scholarly journals NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia

2017 ◽  
Vol 4 (10) ◽  
pp. 722-738 ◽  
Author(s):  
Rafael Galindo ◽  
Marianne Banks Greenberg ◽  
Toshiyuki Araki ◽  
Yo Sasaki ◽  
Nehali Mehta ◽  
...  
Keyword(s):  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

Detection of Free Radicals in Cerebral Tissue and their Relation to Cerebral Hypoxia/Ischemia

1988 ◽  
pp. 321-335
Author(s):  
Shigeki Imaizumi ◽  
Teiji Tominaga ◽  
Hiroshi Uenohara ◽  
Hiroyuki Kinouchi ◽  
Takashi Yoshimoto ◽  
...  
Keyword(s):  
Free Radicals ◽  
Cerebral Hypoxia ◽  
Cerebral Tissue ◽  
Hypoxia Ischemia

scholarly journals Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia‐ischemia

2018 ◽  
Vol 70 (1) ◽  
pp. 56-66 ◽  
Author(s):  
Gabriella Koning ◽  
Ellinor Lyngfelt ◽  
Pernilla Svedin ◽  
Anna‐Lena Leverin ◽  
Masako Jinnai ◽  
...  
Keyword(s):  
Magnesium Sulphate ◽  
Cerebral Hypoxia ◽  
Rodent Models ◽  
Hypoxia Ischemia

Neuroprotective Effect of Long-term MgSO4 Administration After Cerebral Hypoxia-Ischemia in Newborn Rats Is Related to the Severity of Brain Damage

2007 ◽  
Vol 14 (7) ◽  
pp. 667-677 ◽  
Author(s):  
Evangelia Spandou ◽  
Vassiliki Soubasi ◽  
Stamatia Papoutsopoulou ◽  
Persefoni Augoustides-Savvopoulou ◽  
Theodoros Loizidis ◽  
...  
Keyword(s):  
Brain Damage ◽  
Neuroprotective Effect ◽  
Cerebral Hypoxia ◽  
Newborn Rats ◽  
Hypoxia Ischemia

scholarly journals The Effect of Infusing Hypoxanthine or Xanthine During Cerebral Hypoxia-Ischemia on Brain Injury in Rabbits. • 1743

1997 ◽  
Vol 41 ◽  
pp. 293-293 ◽  
Author(s):  
Richard B. Mink ◽  
Jill A. Johnston ◽  
Thomas Foy
Keyword(s):  
Brain Injury ◽  
Cerebral Hypoxia ◽  
Hypoxia Ischemia

scholarly journals NEUTROPENIA PRESERVES ENERGY METABOLITES DURING CEREBRAL HYPOXIA-ISCHEMIA IN THE NEONATAL RAT. † 2256

1996 ◽  
Vol 39 ◽  
pp. 379-379
Author(s):  
Charles Palmer ◽  
Pamela Young ◽  
Rebecca L Roberts
Keyword(s):  
Neonatal Rat ◽  
Cerebral Hypoxia ◽  
Energy Metabolites ◽  
Hypoxia Ischemia
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