Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches

2009 ◽  
pp. 151-178 ◽  
Author(s):  
Bianca De Filippis ◽  
Laura Ricceri ◽  
Giovanni Laviola
Keyword(s):  
Rett Syndrome ◽  
Mouse Models ◽  
Therapeutic Approaches ◽  
Genetic Mouse Models

Mecp2 Knockout in Mouse Models of Rett Syndrome

2013 ◽  
Author(s):  
Megumi Adachi ◽  
Lisa M. Monteggia
Keyword(s):  
Rett Syndrome ◽  
Mouse Models ◽  
Mutant Mice ◽  
Therapeutic Approaches ◽  
Clinical Phenotypes

Chapter 6 reviews the phenotypes of the constitutive Mecp2 KO mutant mice, those generated by expressing RTT -causing mutations, and conditional Mecp2 KO mice in comparison to clinical phenotypes presented in patients with RTT. It also covers therapeutic approaches currently reported using these RTT -model mice.

scholarly journals Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome

2013 ◽  
Vol 33 (34) ◽  
pp. 13612-13620 ◽  
Author(s):  
S. K. Garg ◽  
D. T. Lioy ◽  
H. Cheval ◽  
J. C. McGann ◽  
J. M. Bissonnette ◽  
...  
Keyword(s):  
Rett Syndrome ◽  
Mouse Models ◽  
Female Mouse ◽  
Systemic Delivery

Rett syndrome treatment in mouse models: Searching for effective targets and strategies

2013 ◽  
Vol 68 ◽  
pp. 106-115 ◽  
Author(s):  
Laura Ricceri ◽  
Bianca De Filippis ◽  
Giovanni Laviola
Keyword(s):  
Rett Syndrome ◽  
Mouse Models
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