scholarly journals MMP-Mediated Disruption of Claudin-5 in the Blood–Brain Barrier of Rat Brain After Cerebral Ischemia

2011 ◽  
pp. 333-345 ◽  
Author(s):  
Yi Yang ◽  
Gary A. Rosenberg
Keyword(s):  
Cerebral Ischemia ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals The Epithelial Membrane Protein 1 is a Novel Tight Junction Protein of the Blood—Brain Barrier

2008 ◽  
Vol 28 (6) ◽  
pp. 1249-1260 ◽  
Author(s):  
Thorsten Bangsow ◽  
Ewa Baumann ◽  
Carmen Bangsow ◽  
Martina H Jaeger ◽  
Bernhard Pelzer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerebral Ischemia ◽  
Membrane Protein ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Differentially Expressed ◽  
Brain Barrier ◽  
Brain Vessels ◽  
Blood Brain ◽  
Junction Protein

In the central nervous system, a constant microenvironment required for neuronal cell activity is maintained by the blood—brain barrier (BBB). The BBB is formed by the brain microvascular endothelial cells (BMEC), which are sealed by tight junctions (TJ). To identify genes that are differentially expressed in BMEC compared with peripheral endothelial cells, we constructed a subtractive cDNA library from porcine BMEC (pBMEC) and aortic endothelial cells (AOEC). Screening the library for differentially expressed genes yielded 26 BMEC-specific transcripts, such as solute carrier family 35 member F2 (SLC35F2), ADP-ribosylation factor-like 5B (ARL5B), TSC22 domain family member 1 (TSC22D1), integral membrane protein 2A (ITM2A), and epithelial membrane protein 1 (EMP1). In this study, we show that EMP1 transcript is enriched in pBMEC compared with brain tissue and that EMP1 protein colocalizes with the TJ protein occludin in mouse BMEC by coimmunoprecipitation and in rat brain vessels by immunohistochemistry. Epithelial membrane protein 1 expression was transiently induced in laser-capture microdissected rat brain vessels after a 20-min global cerebral ischemia, in parallel with the loss of occludin immunoreactivity. The study identifies EMP1 as a novel TJ-associated protein of the BBB and suggests its potential role in the regulation of the BBB function in cerebral ischemia.

Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S266-S266
Author(s):  
Roland Veltkamp ◽  
Li Sun ◽  
Dirk A Siebing ◽  
Katja Bieber ◽  
Sabine Heiland ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Hyperbaric Oxygen ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Transient Focal Cerebral Ischemia ◽  
Blood Brain Barrier Damage

scholarly journals Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier

Molecules ◽  
2013 ◽  
Vol 18 (9) ◽  
pp. 11537-11552 ◽  
Author(s):  
Ruth Hemmer ◽  
Andrew Hall ◽  
Robert Spaulding ◽  
Brett Rossow ◽  
Michael Hester ◽  
...  
Keyword(s):  
Rat Brain ◽  
Blood Brain Barrier ◽  
Pamam Dendrimer ◽  
Brain Barrier ◽  
Cellular Model ◽  
Blood Brain

Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest

1994 ◽  
Vol 633 (1-2) ◽  
pp. 41-52 ◽  
Author(s):  
R. Pluta ◽  
A.S. Lossinsky ◽  
H.M. Wis´niewski ◽  
M.J. Mossakowski
Keyword(s):  
Cardiac Arrest ◽  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Complete Cerebral Ischemia
Sign in / Sign up

Export Citation Format

Share Document