Epistasis, Complexity, and Multifactor Dimensionality Reduction

2013 ◽  
pp. 465-477 ◽  
Author(s):  
Qinxin Pan ◽  
Ting Hu ◽  
Jason H. Moore
Keyword(s):  
Dimensionality Reduction ◽  
Multifactor Dimensionality Reduction

СONTRIBUTION OF POLYMORPHIC VARIATION OF ТP53 AND XRCC1 GENES TO THE SUSCEPTIBILITY TO BREAST CANCER FOR WOMEN OF KYRGYZ AND BELARUSIAN NATIONALITY - A COMPARATIVE STUDY ON MULTIFACTOR DIMENSIONALITY REDUCTION METHODS

2018 ◽  
Vol 64 (1) ◽  
pp. 95-101
Author(s):  
Nazira Aldasheva ◽  
Vyacheslav Kipen ◽  
Zhaynagul Isakova ◽  
Sergey Melnov ◽  
Raisa Smolyakova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dimensionality Reduction ◽  
Multifactor Dimensionality Reduction ◽  
Rflp Analysis ◽  
Kyrgyz Republic ◽  
Increased Risk ◽  
Polymorphic Variants ◽  
The Republic

Basing on Multifactor Dimensionality Reduction method we showed that polymorphic variants p.Q399R (rs25487, XRCC1) and p.P72R (rs1042522, TP53) correlated with increased risk of breast cancer for women from the Kyrgyz Republic and the Republic of Belarus. Cohort for investigation included patients with clinically verified breast cancer: 117 women from the Kyrgyz Republic (nationality - Kyrgyz) and 169 - of the Republic of Belarus (nationality - Belarusians). Group for comparison included (healthy patients without history of cancer pathology at the time of blood sampling) 102 patients from the Kyrgyz Republic, 185 - from the Republic of Belarus. Respectively genotyping of polymorphic variants p.Q399R (rs25487, XRCC1) and p.P72R (rs1042522, TP53) was done by PCR-RFLP. Analysis of the intergenic interactions conducted with MDR 3.0.2 software. Both ethnic groups showed an increase of breast cancer risk in the presence of alleles for SNPs Gln p.Q399R (XRCC1) in the heterozygous state: for the group “Kyrgyz” - OR=2,78 (95% CI=[1,60-4,82]), p=0,001; for the group “Belarusians” - OR=1,85 (95% СІ=[1Д1-2,82], p=0,004. Carriers with combination of alleles Gln (p.Q399R, XRCC1) and Pro (p.P72R, TP53) showed statistically significance increases of breast cancer risk as for patients from the Kyrgyz Republic (OR=2,89, 95% CI=[1,33-6,31]), so as for patients from the Republic of Belarus (OR=3,01, 95% CI=[0,79-11,56]).

Multifactor-dimensionality reduction reveals interaction of important gene variants involved in allergy

2015 ◽  
Vol 42 (3) ◽  
pp. 182-189 ◽  
Author(s):  
R. M. de Guia ◽  
M. D. J. Echavez ◽  
E. L. C. Gaw ◽  
M. R. R. Gomez ◽  
K. A. J. Lopez ◽  
...  
Keyword(s):  
Dimensionality Reduction ◽  
Multifactor Dimensionality Reduction ◽  
Gene Variants

Maize Epistasis Detection by Multi-class Quantitative Multifactor Dimensionality Reduction

2021 ◽  
Author(s):  
Xin Wang ◽  
Jun Wang ◽  
Guoxian Yu ◽  
Beibei Xin ◽  
Maozu Guo
Keyword(s):  
Dimensionality Reduction ◽  
Multifactor Dimensionality Reduction
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