Inadequate Laser Coagulation

Author(s):  
Ulrich Spandau ◽  
Sang Jin Kim
Keyword(s):  
2006 ◽  
Vol 175 (4S) ◽  
pp. 490-490
Author(s):  
Stefan Zastrow ◽  
Sven Oehlschläger ◽  
Oliver W. Hakenberg ◽  
Steffen Leike ◽  
Manfred P. Wirth

2005 ◽  
Vol 173 (4S) ◽  
pp. 424-425
Author(s):  
Kenji Mitsumori ◽  
Koji Nishizawa ◽  
Takashi Kawahara ◽  
Jun Watanabe ◽  
Takashi Kobayashi ◽  
...  

Skull Base ◽  
2009 ◽  
Vol 19 (S 02) ◽  
Author(s):  
K. Apostolopoulos ◽  
G. Karkatzoulis
Keyword(s):  

Author(s):  
V.A. Zaika ◽  
◽  
A.G. Shchuko ◽  
E.V. Arkhipov ◽  
V.V. Bukina ◽  
...  

2014 ◽  
Vol 47 (1) ◽  
pp. 48-51
Author(s):  
P. Chechin ◽  
◽  
I. Safronenkova ◽  
O. Guzun ◽  
V. Repyah ◽  
...  

2010 ◽  
Vol 24 (2) ◽  
pp. 4-7
Author(s):  
N. Pasechnikova ◽  
◽  
V. Naumenko ◽  
I. Metelitsina ◽  
V. Belyaev ◽  
...  

2019 ◽  
Vol 16 (3) ◽  
pp. 258-265
Author(s):  
Kei Takahashi ◽  
Tomomi Masuda ◽  
Mitsunori Harada ◽  
Tadashi Inoue ◽  
Shinsuke Nakamura ◽  
...  

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.


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