Glutamate Receptor Auxiliary Subunits and Interacting Protein Partners in the Cerebellum

2021 ◽  
pp. 929-955
Author(s):  
Ian D. Coombs ◽  
Stuart G. Cull-Candy
2013 ◽  
Vol 39 (3) ◽  
pp. 759-769 ◽  
Author(s):  
Lisa A Briand ◽  
Blake A Kimmey ◽  
Pavel I Ortinski ◽  
Richard L Huganir ◽  
R Christopher Pierce

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Issam El Ghazi ◽  
Bruce L. Martin ◽  
Ian M. Armitage

Metallothionein 3 (MT-3), also known as growth inhibitory factor (GIF), exhibits a neuroinhibitory activity. Our lab and others have previously shown that this biological activity involves interacting protein partners in the brain. However, nothing specific is yet known about which of these interactions is responsible for the GIF activity. In this paper, we are reporting upon new proteins found interacting with MT-3 as determined through immunoaffinity chromatography and mass spectrometry. These new partner proteins—Exo84p, 14-3-3 Zeta,αandβEnolase, Aldolase C, Malate dehydrogenase, ATP synthase, and Pyruvate kinase—along with those previously identified have now been classified into three functional groups: transport and signaling, chaperoning and scaffolding, and glycolytic metabolism. When viewed together, these interactions support a proposed model for the regulation of the GIF activity of MT-3.


Biomolecules ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 35 ◽  
Author(s):  
Andreas Hähle ◽  
Stephanie Merz ◽  
Christian Meyners ◽  
Felix Hausch

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51’s physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.


2008 ◽  
Vol 105 (6) ◽  
pp. 2300-2314 ◽  
Author(s):  
Wendou Yu ◽  
Erik I. Charych ◽  
David R. Serwanski ◽  
Rong-wen Li ◽  
Rashid Ali ◽  
...  

Data in Brief ◽  
2014 ◽  
Vol 1 ◽  
pp. 76-78 ◽  
Author(s):  
Pak-Kei Chan ◽  
Tharan Srikumar ◽  
Dharmendra Dingar ◽  
Manpreet Kalkat ◽  
Linda Z. Penn ◽  
...  

2001 ◽  
Vol 304 (1-2) ◽  
pp. 81-84 ◽  
Author(s):  
Maya Yamazaki ◽  
Masahiro Fukaya ◽  
Manabu Abe ◽  
Kanju Ikeno ◽  
Toshikazu Kakizaki ◽  
...  

2002 ◽  
Vol 277 (43) ◽  
pp. 41140-41146 ◽  
Author(s):  
Wei Feng ◽  
Jing-Song Fan ◽  
Ming Jiang ◽  
Ya-Wei Shi ◽  
Mingjie Zhang

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