scholarly journals Heparanase in Cancer Metastasis – Heparin as a Potential Inhibitor of Cell Adhesion Molecules

2020 ◽  
pp. 309-329 ◽  
Author(s):  
G. Bendas ◽  
Lubor Borsig
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Potential Inhibitor

scholarly journals The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chee Wai Wong ◽  
Danielle E. Dye ◽  
Deirdre R. Coombe
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cancer Progression ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Clinical Problem ◽  
Metastatic Lesion ◽  
Immunoglobulin Superfamily ◽  
Metastatic Pathway ◽  
Cell Cell

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes.

scholarly journals miR-19b promotes breast cancer metastasis through targeting MYLIP and its related cell adhesion molecules

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 64330-64343 ◽  
Author(s):  
Luqing Zhao ◽  
Yuelong Zhao ◽  
Yanong He ◽  
Yitao Mao
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Related Cell

Expression of cell adhesion molecules on ovarian tumour cell lines and mesothelial cells, in relation to ovarian cancer metastasis

1995 ◽  
Vol 91 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Michael J. Gardner ◽  
Lindsay M.H. Jones ◽  
Jonathan B. Catterall ◽  
Graham A. Turner
Keyword(s):  
Ovarian Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Lines ◽  
Tumour Cell ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Ovarian Tumour ◽  
Mesothelial Cells ◽  
Tumour Cell Lines

scholarly journals The Interplay Between the Cell Adhesion Molecules CD44 and CD146 in Breast Cancer Metastasis

2014 ◽  
Vol 25 ◽  
pp. i23
Author(s):  
I. Gupta ◽  
M.E. Abdraboh ◽  
A.D. Hollenbach ◽  
S. Shanmuganathan ◽  
H. Al-Riyami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis
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