Ligament Tissue Engineering: The Anterior Cruciate Ligament

2021 ◽  
pp. 489-506
Author(s):  
Thomas Nau ◽  
Andreas Teuschl
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Anterior Cruciate ◽  
Ligament Tissue Engineering

Long-term hydrolytic degradation study on polymer-based embroidered scaffolds for ligament tissue engineering

2017 ◽  
Vol 47 (6) ◽  
pp. 1305-1320 ◽  
Author(s):  
Judith Hahn ◽  
Annette Breier ◽  
Harald Brünig ◽  
Gert Heinrich
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Polylactic Acid ◽  
Cruciate Ligament ◽  
Hydrolytic Degradation ◽  
Ligament Injury ◽  
Degradation Behaviour ◽  
Native Anterior Cruciate Ligament ◽  
Anterior Cruciate ◽  
Ligament Tissue Engineering

Following anterior cruciate ligament injury, a mechanically stable tissue replacement is required for knee stability and to avoid subsequent damages. Tissue engineering of the anterior cruciate ligament demands a biocompatible scaffold with a controllable degradation profile to provide mechanical support for 3 to 6 months. It has been argued that embroidered textile scaffolds made of polylactic acid and poly(lactic-co-ɛ-caprolactone) fibres are a promising approach for the ligament tissue engineering with an adapted functionalization and cell seeding strategy. Therefore, the hydrolytic degradation behaviour of embroidered scaffolds made of polylactic acid and a combination of polylactic acid and poly(lactic-co-ɛ-caprolactone) fibres was investigated under physiological conditions for 168 days. The changes in the mechanical behaviour, the molecular weights as well as the surface structures were analysed. Sufficient mechanical properties comparable to native anterior cruciate ligament tissue could be demonstrated for scaffolds made of polylactic acid fibres after 6 months under hydrolysis. These results clarify the potential of using embroidered scaffolds for ligament tissue engineering.

Graphene Oxide Reinforced Degradable Polyurethane for Anterior Cruciate Ligament Tissue Engineering

2014 ◽  
Vol 898 ◽  
pp. 304-307 ◽  
Author(s):  
Jing Ling Zhang ◽  
Lin Guo ◽  
Long Chen ◽  
Shuai Hua Li ◽  
Gang Wu
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Cruciate Ligament ◽  
Oxide Composite ◽  
Composite Modulus ◽  
Good Biocompatibility ◽  
Anterior Cruciate ◽  
Ligament Tissue Engineering

Here we report the development of Poly Urethane (PU)/ graphene oxide composite used as the scaffold of anterior cruciate ligament tissue engineering. The influences of the GO on the composite were studied by FTIR, SEM and XRD. The Youngs modulus of the composite is 30.6 MPa compared to that of PU`s 6.8 MPa. The GO induced heterogeneous crystal increasing should be the reason for the composite modulus improving, as well as the interaction between the GO and PU. The good biocompatibility of the composite testified by cell viability experiment indicates the promising candidates of the material as the ACL tissue engineering scaffold.

scholarly journals Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
E. W. Yates ◽  
A. Rupani ◽  
G. T. Foley ◽  
W. S. Khan ◽  
S. Cartmell ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Reconstruction ◽  
Animal Studies ◽  
Ligament Reconstruction ◽  
Cruciate Ligament ◽  
Biomechanical Properties ◽  
Cruciate Ligament Reconstruction ◽  
Anterior Cruciate ◽  
Ligament Tissue Engineering

Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction.

Potential of Skin Fibroblasts for Application to Anterior Cruciate Ligament Tissue Engineering

2011 ◽  
Vol 20 (4) ◽  
pp. 535-542 ◽  
Author(s):  
Pierrot Tremblay ◽  
Réjean Cloutier ◽  
Jean Lamontagne ◽  
Anne-Marie Belzil ◽  
Anne-Marie Larkin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Skin Fibroblasts ◽  
Anterior Cruciate ◽  
Ligament Tissue Engineering
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