20-Year-Old Female with Diffuse Itchy, Scaly Skin

Author(s):  
Erica Haught ◽  
Austin Cusick ◽  
Shannon C. Trotter
Keyword(s):  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Brigitte Burcescu ◽  
Heather L. Brumberg ◽  
Shetal I. Shah

Abstract Objectives X-linked ichthyosis (XLI) is a genetic disorder caused by a deficiency in steroid sulfatase, an enzyme which catalyzes a reaction in estrone synthesis. The disorder primarily manifests as dry, scaly skin which may be difficult to diagnose in extremely preterm infants, as the dermatological features may be falsely attributed to a normal variant of skin for this population. Case presentation In this case report, we describe a male with XLI, born at 24 weeks gestation, who had persistent dry, flaky and hyperpigmented skin. This case is notable for the age of diagnosis in an extremely premature infant; day of life 105. In addition, this infant experienced out of proportion bronchopulmonary symptoms that we postulate may be linked to the steroid sulfatase deficiency, as estrogen is a mediator of surfactant production. Conclusions This report underscores the need to potentially evaluate persistent dry, flaky skin in the preterm infant, as XLI may also impact long term neurodevelopmental outcomes.


2020 ◽  
pp. 403-416

This chapter on dry skin disorders describes a range of mainly genetic dermatoses whose predominant feature is dry scaly skin. It excludes conditions such as eczema where dry skin is a secondary clinical sign. The underlying mechanism of dry scaly skin is briefly discussed and an algorithm points to possible diagnoses. The focus is on the genetic ichthyoses, defined as congenital, lifelong, generalized dry and scaly skin. The common ichthyoses are non-inflammatory (ichthyosis vulgaris and X-linked recessive ichthyosis) but there are several inflammatory ichthyoses, some associated with fragile skin (blistering) and several with multisystem complications, such as Netherton syndrome. Salient features of each are reviewed with illustrations of selected cases and management is outlined. Two important neonatal presentations, collodion baby and harlequin ichthyosis, are described.


Gut ◽  
2019 ◽  
Vol 68 (11) ◽  
pp. 1960-2018
Author(s):  
Philipp Kasper ◽  
Tobias Goeser ◽  
Dirk Nierhoff

2019 ◽  
Vol 28 (8) ◽  
pp. 534-541
Author(s):  
Claas Roes ◽  
Leanne Calladine ◽  
Clare Morris

Objective: To determine the clinical effect and consequential levels of health professionals and patient satisfaction with the results of debridement episodes of wounds with visible slough and/or scaly skin using monofilament fibre debridement technology. Methods: This was a non-comparative, open label evaluation conducted in static/non-healing acute and chronic wounds with visible slough and/or scaly skin that required debridement. Monofilament fibre debridement technology was applied in 1–2 sequential treatment episodes during normal clinical practice which followed local practice, guidelines or formularies. Following the clinical phase of the evaluation, health professionals were invited to complete an online survey of the clinical outcomes and their satisfaction with them. Results: Survey questions were answered by 1129 health professionals. Wounds managed using the monofilament fibre debridement technology during this evaluation included leg ulcers (63%), pressure ulcers (10%), dehisced surgical wounds (3%), diabetic foot ulcers (8%) and other wounds (13%). ‘Other’ wound types included acute dirty wounds, burns, cellulitis, psoriasis, diabetic amputation wounds, dry flaky skin, moisture wounds, trauma, varicose eczema. Of the wounds, 12% were reported as non-static. There was visible change in the wound and/or skin after first use of the monofilament fibre debridement technology in a high proportion of all wound types, and a further increase in the proportion of wounds with visible change after the second use. The visible difference was significant for both static and non-static wounds. User and patient satisfaction with all clinical outcomes were high, whether or not the user and patient had previous experience of monofilament fibre debridement technology. Conclusion: Monofilament fibre debridement technology provides rapid, visible and effective debridement of slough and scaly skin after one application and further visible improvement after two applications in static and non-static wounds. Health professionals and patients report high levels of satisfaction with outcomes following application of the monofilament fibre debridement technology.


2020 ◽  
Vol 42 (6) ◽  
pp. 564-572
Author(s):  
Satoko Fukagawa ◽  
Ayami Takahashi ◽  
Keimon Sayama ◽  
Shinobu Mori ◽  
Takatoshi Murase

2002 ◽  
Vol 19 (5) ◽  
pp. 457-459 ◽  
Author(s):  
Joy M. Twersky ◽  
Anita P. Sheth ◽  
Anne W. Lucky
Keyword(s):  

Author(s):  
Senai Sereke ◽  
Semhar Berhe ◽  
Felix Bongomin

We are presenting a newborn with a very rare and most severe form of congenital ichthyosis that is characterized by a thick, heavily keratinized and scaly skin.


Development ◽  
1960 ◽  
Vol 8 (4) ◽  
pp. 387-395
Author(s):  
R. I. Spearman

The skin defect ‘ichthyosis’ of the house mouse is caused by a simple recessive gene (symbol ic) which arose as a spontaneous mutation. It was first described by Carter & Phillips (1950). ‘Ichthyotic’ mice have a thin coat of very short wavy hairs together with a scaly skin. There is, however, considerable individual variation in the severity of the defect. In badly affected animals the stratum corneum of the back is shed as large flakes, and the mice may be almost bald; but in less affected mice the skin is not very scaly and there is a complete though abnormal hair cover. The tail skin has a hard smooth appearance and is less flexible than normal. In some older mice a number of depressed rings form along its length, and a portion of the tail undergoes necrosis and drops off distal to one of the constrictions.


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