The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors

2021 ◽  
pp. 1-16
Author(s):  
Eszter Kótyuk ◽  
Marc N. Potenza ◽  
Kenneth Blum ◽  
Zsolt Demetrovics
Keyword(s):  
Deficiency Syndrome ◽  
Reward Deficiency Syndrome

Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land?

2015 ◽  
Vol 15 (7) ◽  
pp. 973-985 ◽  
Author(s):  
Kenneth Blum ◽  
Peter K Thanos ◽  
Rajendra D Badgaiyan ◽  
Marcelo Febo ◽  
Marlene Oscar-Berman ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Deficiency Syndrome ◽  
Promised Land ◽  
Reward Deficiency Syndrome

scholarly journals The D2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

1996 ◽  
Vol 89 (7) ◽  
pp. 396-400 ◽  
Author(s):  
K Blum ◽  
P J Sheridan ◽  
R C Wood ◽  
E R Braverman ◽  
T J H Chen ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Gene ◽  
Deficiency Syndrome ◽  
Brain Dysfunction ◽  
Genetic Determinants ◽  
Hyperactivity Disorder ◽  
Reward Deficiency Syndrome ◽  
Dopamine Receptor Gene ◽  
The Brain ◽  
D2 Dopamine Receptor Gene

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the ‘reward deficiency syndrome’.

Gene Narcotic Attenuation Program attenuates substance use disorder, a clinical subtype of reward deficiency syndrome

2007 ◽  
Vol 24 (2) ◽  
pp. 402-414 ◽  
Author(s):  
Thomas J. H. Chen ◽  
Kenneth Blum ◽  
Roger L. Waite ◽  
Brian Meshkin ◽  
John Schoolfield ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorder ◽  
Deficiency Syndrome ◽  
Reward Deficiency Syndrome ◽  
Clinical Subtype
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