Genome Wide Sequencing Compared to Candidate Gene Association Studies for Predisposition to Substance Abuse a Subset of Reward Deficiency Syndrome (RDS): Are we throwing the Baby Out with the Bathwater?

2014 ◽  
Vol 04 (03) ◽  
Author(s):  
Kenneth Blum Eric R. Braverman
Keyword(s):  
Substance Abuse ◽  
Candidate Gene ◽  
Association Studies ◽  
Deficiency Syndrome ◽  
Gene Association ◽  
Candidate Gene Association ◽  
Genome Wide ◽  
Reward Deficiency Syndrome

scholarly journals Systematic re-evaluation of genes from candidate gene association studies in migraine using a large genome-wide association data set

Cephalalgia ◽  
2015 ◽  
Vol 36 (7) ◽  
pp. 604-614 ◽  
Author(s):  
Boukje de Vries ◽  
Verneri Anttila ◽  
Tobias Freilinger ◽  
Maija Wessman ◽  
Mari A Kaunisto ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Association Studies ◽  
Small Sample ◽  
Gwas Data ◽  
Genome Wide Association ◽  
Data Set ◽  
Genetic Studies ◽  
Gene Association ◽  
Candidate Gene Association ◽  
Genome Wide

Background Before the genome-wide association (GWA) era, many hypothesis-driven candidate gene association studies were performed that tested whether DNA variants in genes that had been selected based on prior knowledge about migraine pathophysiology were associated with migraine. Most studies involved small sample sets without robust replication, thereby making the risk of false-positive findings high. Genome-wide marker data of thousands of migraine patients and controls from the International Headache Genetics Consortium provide a unique opportunity to re-evaluate key findings from candidate gene association studies (and other non-GWA genetic studies) in a much larger data set. Methods We selected 21 genes from published candidate gene association studies and six additional genes from other non-GWA genetic studies in migraine. Single nucleotide polymorphisms (SNPs) in these genes, as well as in the regions 500 kb up- and downstream, were inspected in IHGC GWAS data from 5175 clinic-based migraine patients with and without aura and 13,972 controls. Results None of the SNPs in or near the 27 genes, including the SNPs that were previously found to be associated with migraine, reached the Bonferroni-corrected significance threshold; neither when analyzing all migraine patients together, nor when analyzing the migraine with and without aura patients or males and females separately. Conclusion The available migraine GWAS data provide no clear evidence for involvement of the previously reported most promising candidate genes in migraine.

scholarly journals Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population

2015 ◽  
Vol 30 (5) ◽  
pp. 719-726 ◽  
Author(s):  
Sook Kyung Do ◽  
Seung Soo Yoo ◽  
Yi Young Choi ◽  
Jin Eun Choi ◽  
Hyo-Sung Jeon ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Telomere Length ◽  
Association Studies ◽  
Korean Population ◽  
Gene Association ◽  
Candidate Gene Association ◽  
Genome Wide

Humans, fruit flies, and automatons

2012 ◽  
Vol 35 (5) ◽  
pp. 381-410 ◽  
Author(s):  
Evan Charney
Keyword(s):  
Candidate Gene ◽  
Human Nature ◽  
Twin Study ◽  
Behavior Genetics ◽  
Association Studies ◽  
Fruit Flies ◽  
Gene Association ◽  
Candidate Gene Association ◽  
Target Article ◽  
Study Methodology

AbstractMy response is divided into four sections: (1) is devoted to a potpourri of commentaries that are essentially in agreement with the substance of my target article (with one exception); in (2) I address, in response to one of the commentaries, several issues relating to the use of candidate gene association studies in behavior genetics (in particular those proposing a specific G×E interaction); in (3) I provide a detailed response to several defenses of the twin study methodology; and in (4) I conclude with several reflections on that methodology and the conception of human nature it has fostered.

Sign in / Sign up

Export Citation Format

Share Document