Design for X – Site-Specific Adaptation of Production Processes and Products

2021 ◽  
pp. 117-127
Author(s):  
Shun Yang ◽  
Sina Peukert ◽  
Gisela Lanza
Keyword(s):  
Site Specific ◽  
Specific Adaptation ◽  
Design For X ◽  
Production Processes

GLOBAL AND SITE-SPECIFIC ADAPTATION OF CANCELLOUS BONE TO IN VIVO LOADING

2012 ◽  
Vol 45 ◽  
pp. S97
Author(s):  
Annette Birkhold ◽  
Hajar Razi ◽  
Tobias Thiele ◽  
Sara Checa ◽  
Georg Duda ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Site Specific ◽  
Specific Adaptation ◽  
In Vivo Loading

243. Human myometrial T cells at the maternal-fetal interface are tissue-resident memory T cells, which show site-specific adaptation within one tissue

2018 ◽  
Vol 13 ◽  
pp. S34
Author(s):  
Laura Brouwers ◽  
Judith Wienke ◽  
Tatjana Vogelvang ◽  
Arie Franx ◽  
Femke van Wijk ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Site Specific ◽  
Specific Adaptation ◽  
Resident Memory T Cells ◽  
Maternal Fetal Interface

scholarly journals Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum

2013 ◽  
Vol 208 (7) ◽  
pp. 1170-1174 ◽  
Author(s):  
Christopher L. Peatey ◽  
Jolanta A. Watson ◽  
Katharine R. Trenholme ◽  
Christopher L. Brown ◽  
Lars Nielson ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Progenitor Cells ◽  
Site Specific ◽  
Specific Adaptation ◽  
A Site

scholarly journals Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

JCI Insight ◽  
2020 ◽  
Vol 5 (18) ◽  
Author(s):  
Judith Wienke ◽  
Laura Brouwers ◽  
Leone M. van der Burg ◽  
Michal Mokry ◽  
Rianne C. Scholman ◽  
...  
Keyword(s):  
Site Specific ◽  
Specific Adaptation

Gqα subunit mediates receptor site-specific adaptation in the sugar taste receptor cell of the blowfly, Phormia regina

2005 ◽  
Vol 377 (3) ◽  
pp. 200-205 ◽  
Author(s):  
Keiji Seno ◽  
Kazuyo Fujikawa ◽  
Tadashi Nakamura ◽  
Mamiko Ozaki
Keyword(s):  
Receptor Cell ◽  
Taste Receptor ◽  
Receptor Site ◽  
Phormia Regina ◽  
Taste Receptor Cell ◽  
Site Specific ◽  
Specific Adaptation

Site-specific adaptation of the growing skeleton to altered mechanical stimuli

1992 ◽  
Vol 25 (6) ◽  
pp. 669
Author(s):  
Ted S. Gross ◽  
Clinton T. Rubin
Keyword(s):  
Mechanical Stimuli ◽  
Site Specific ◽  
Specific Adaptation

Large-cluster and combined fluorescent and gold immunoprobes

1996 ◽  
Vol 54 ◽  
pp. 892-893
Author(s):  
Richard D. Powell ◽  
James F. Hainfeld ◽  
Carol M. R. Halsey ◽  
David L. Spector ◽  
Shelley Kaurin ◽  
...  
Keyword(s):  
Metal Cluster ◽  
Sulfonyl Chloride ◽  
Gel Filtration ◽  
Cross Linking ◽  
Site Specific ◽  
Fab Fragments ◽  
Cluster Label ◽  
Covalently Linked ◽  
Texas Red ◽  
Fold Excess

Two new types of covalently linked, site-specific immunoprobes have been prepared using metal cluster labels, and used to stain components of cells. Combined fluorescein and 1.4 nm “Nanogold” labels were prepared by using the fluorescein-conjugated tris (aryl) phosphine ligand and the amino-substituted ligand in the synthesis of the Nanogold cluster. This cluster label was activated by reaction with a 60-fold excess of (sulfo-Succinimidyl-4-N-maleiniido-cyclohexane-l-carboxylate (sulfo-SMCC) at pH 7.5, separated from excess cross-linking reagent by gel filtration, and mixed in ten-fold excess with Goat Fab’ fragments against mouse IgG (obtained by reduction of F(ab’)2 fragments with 50 mM mercaptoethylamine hydrochloride). Labeled Fab’ fragments were isolated by gel filtration HPLC (Superose-12, Pharmacia). A combined Nanogold and Texas Red label was also prepared, using a Nanogold cluster derivatized with both and its protected analog: the cluster was reacted with an eight-fold excess of Texas Red sulfonyl chloride at pH 9.0, separated from excess Texas Red by gel filtration, then deprotected with HC1 in methanol to yield the amino-substituted label.

The challenge of detecting modifications on proteins

2020 ◽  
Vol 64 (1) ◽  
pp. 135-153 ◽  
Author(s):  
Lauren Elizabeth Smith ◽  
Adelina Rogowska-Wrzesinska
Keyword(s):  
Mass Spectrometry ◽  
Protein Function ◽  
Chemical Properties ◽  
Lysine Acetylation ◽  
Mass Determination ◽  
Post Translational Modifications ◽  
Site Specific ◽  
The Common

Abstract Post-translational modifications (PTMs) are integral to the regulation of protein function, characterising their role in this process is vital to understanding how cells work in both healthy and diseased states. Mass spectrometry (MS) facilitates the mass determination and sequencing of peptides, and thereby also the detection of site-specific PTMs. However, numerous challenges in this field continue to persist. The diverse chemical properties, low abundance, labile nature and instability of many PTMs, in combination with the more practical issues of compatibility with MS and bioinformatics challenges, contribute to the arduous nature of their analysis. In this review, we present an overview of the established MS-based approaches for analysing PTMs and the common complications associated with their investigation, including examples of specific challenges focusing on phosphorylation, lysine acetylation and redox modifications.

The Need for a Broad-Based Model of Phonological Disorders

1992 ◽  
Vol 23 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Alan G. Kamhi
Keyword(s):  
Speech Production ◽  
Phonological Disorders ◽  
Production Processes ◽  
Assessment And Treatment ◽  
Speech Delays ◽  
Explanatory Adequacy ◽  
State Of Affairs ◽  
Assessment Procedures ◽  
Treatment Procedures

My response to Fey’s article (1985; reprinted 1992, this issue) focuses on the confusion caused by the application of simplistic phonological definitions and models to the assessment and treatment of children with speech delays. In addition to having no explanatory adequacy, such definitions/models lead either to assessment and treatment procedures that are similarly focused or to procedures that have no clear logical ties to the models with which they supposedly are linked. Narrowly focused models and definitions also usually include no mention of speech production processes. Bemoaning this state of affairs, I attempt to show why it is important for clinicians to embrace broad-based models of phonological disorders that have some explanatory value. Such models are consistent with assessment procedures that are comprehensive in nature and treatment procedures that focus on linguistic, as well as motoric, aspects of speech.

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