Small Cell Lung Cancer: Biology Advances

2021 ◽  
pp. 197-211
Author(s):  
Christine L. Hann
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Small Cell ◽  
Small Cell Lung

Antiapoptotic Signaling Pathways in Non–Small-Cell Lung Cancer: Biology and Therapeutic Strategies

2004 ◽  
Vol 6 (2) ◽  
pp. 113-122 ◽  
Author(s):  
Eric B. Haura ◽  
W. Douglas Cress ◽  
Srikumar Chellappan ◽  
Zhong Zheng ◽  
Gerold Bepler
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Therapeutic Strategies ◽  
Small Cell ◽  
Small Cell Lung

Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

2016 ◽  
Vol 33 (2) ◽  
Author(s):  
Biagio Ricciuti ◽  
Clelia Mencaroni ◽  
Luca Paglialunga ◽  
Francesco Paciullo ◽  
Lucio Crinò ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Noncoding Rnas ◽  
Small Cell ◽  
Long Noncoding Rnas ◽  
Small Cell Lung ◽  
Diagnosis And Therapy

scholarly journals Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2

2019 ◽  
Vol 39 (6) ◽  
Author(s):  
Liuxin Wang ◽  
Huiping Ma ◽  
Weixiang Kong ◽  
Bing Liu ◽  
Xueqing Zhang
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Function Analysis ◽  
Small Cell ◽  
Migration And Invasion ◽  
Small Cell Lung ◽  
Nsclc Patients

AbstractCircular RNAs (circRNAs), a group of non-coding RNAs, play an important role in cancer biology, and in the present study, we aimed to clarify the expression profiles and biological functions of circRNA circVANGL1 in non-small cell lung cancer (NSCLC). The results showed that circVANGL1 was overexpressed in human NSCLC tissues and cell lines. circVANGL1 expression was closely associated with tumor size, TNM stage and overall survival of NSCLC patients. Further loss-of-function analysis revealed that knockdown of circVANGL1 inhibited proliferation and induced apoptosis in NSCLC cell lines. The migration and invasion of NSCLC cells were also suppressed by circVANGL1 knockdown. In addition, we predicted that circVANGL1 might serve as a competing endogenous RNA (ceRNA), becoming a sink for miR-195, thereby modulating the expression of Bcl-2 in NSCLC cells. Rescue experiments demonstrated that miR-195 inhibitor abrogated the beneficial role of circVANGL1 knockdown in NSCLC cells. Taken together, we conclude that circVANGL1 functions as an oncogene to promote NSCLC progression partly through miR-195/Bcl-2 axis, which might be a novel therapeutic target for NSCLC patients.

Targeting ALK in patients with advanced Non Small Cell Lung Cancer: Biology, diagnostic and therapeutic options

2014 ◽  
Vol 89 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Chiara Lazzari ◽  
Gianluca Spitaleri ◽  
Chiara Catania ◽  
Massimo Barberis ◽  
Cristina Noberasco ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Biology ◽  
Small Cell ◽  
Therapeutic Options ◽  
Small Cell Lung
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