Primary Polydipsia | ScienceGate

The secretion of arginine vasopressin (AVP) from the posterior pituitary is primarily and finely regulated by the osmolality of plasma. Even though a number of factors alter osmolality-induced release of AVP, there are no published data in humans that have addressed the role of chronic overhydration on this phenomenon. To address this problem we have identified eight patients with primary polydipsia using criteria not involving measurement of AVP, and have subjected them to standardized infusions of hypertonic saline. These patients had less AVP in both plasma and urine in relation to plasma osmolality than was found in normal subjects. In addition, their rate of rise of plasma and urine AVP was less than in normal subjects. Their osmotic threshold for AVP release may have been higher than normal. These data demonstrate that chronic overhydration in humans downregulates the release of AVP in response to hypertonicity. This phenomenon may explain the impairment of urine concentration in patients with primary polydipsia and emphasizes the basis of the difficulty that may occur clinically in differentiating between patients with primary polydipsia and partial central diabetes insipidus.

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Clinical characteristics and relationship between rate of sodium correction and outcomes in patients with primary polydipsia: retrospective observational analysis

Journal of the Japanese Society of Intensive Care Medicine ◽

10.3918/jsicm.28_119 ◽

2021 ◽

Vol 28 (2) ◽

pp. 119-120

Author(s):

Noriko Miyagawa ◽

Hajime Furukawa ◽

Masakazu Kobayashi ◽

Yoshitaro Yoshida ◽

Shigeki Kushimoto

Keyword(s):

Clinical Characteristics ◽

Observational Analysis ◽

Primary Polydipsia ◽

Sodium Correction

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The GLP-1 receptor agonist dulaglutide reduces fluid intake in primary polydipsia: A randomised controlled trial

Endocrine Abstracts ◽

10.1530/endoabs.73.aep467 ◽

2021 ◽

Author(s):

Bettina Winzeler ◽

Clara Sailer ◽

Coynel David ◽

Davide Zanchi ◽

Deborah Vogt ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Receptor Agonist ◽

Fluid Intake ◽

Controlled Trial ◽

Primary Polydipsia ◽

Randomised Controlled

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Re: Severe hyponatraemia as a result of primary polydipsia in labour

Australian and New Zealand Journal of Obstetrics and Gynaecology ◽

10.1111/j.1479-828x.2005.00403.x ◽

2005 ◽

Vol 45 (3) ◽

pp. 259-260

Author(s):

Adam MORTON

Keyword(s):

Primary Polydipsia ◽

Severe Hyponatraemia

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A 27-Month-Old Boy with Polyuria and Polydipsia

Case Reports in Pediatrics ◽

10.1155/2018/4281217 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Yvonne Lee ◽

Erica Winnicki ◽

Lavjay Butani ◽

Stephanie Nguyen

Keyword(s):

Child Development ◽

Anxiety Disorders ◽

Psychiatric Disorder ◽

Water Deprivation ◽

Fluid Intake ◽

Laboratory Studies ◽

Psychogenic Polydipsia ◽

Water Drinking ◽

Primary Polydipsia ◽

Psychiatric Disturbances

Psychogenic polydipsia is a well-described phenomenon in those with a diagnosed psychiatric disorder such as schizophrenia and anxiety disorders. Primary polydipsia is differentiated from psychogenic polydipsia by the lack of a clear psychotic disturbance. We present a case of a 27-month-old boy who presented with polyuria and polydipsia. Laboratory studies, imaging, and an observed water deprivation test were consistent with primary polydipsia. Polydipsia resolved after family limited his fluid intake and began replacing water drinking with other transition objects and behaviors for self-soothing. This case highlights the importance of water deprivation testing to differentiate between causes of polyuria, thereby avoiding misdiagnosis and iatrogenic hyponatremia. Secondly, primary polydipsia can result during the normal stages of child development without overt psychiatric disturbances.

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