Loss of Taste and Smell Function in Cancer Patients

2021 ◽  
pp. 181-201
Author(s):  
Alissa A. Nolden
Keyword(s):  
Cancer Patients ◽  
Smell Function ◽  
Taste And Smell

Changes in taste and smell function, dietary intake, food preference, and body composition in testicular cancer patients treated with cisplatin-based chemotherapy

2017 ◽  
Vol 36 (6) ◽  
pp. 1642-1648 ◽  
Author(s):  
Irene IJpma ◽  
Remco J. Renken ◽  
Jourik A. Gietema ◽  
Riemer H.J.A. Slart ◽  
Manon G.J. Mensink ◽  
...  
Keyword(s):  
Body Composition ◽  
Testicular Cancer ◽  
Dietary Intake ◽  
Cancer Patients ◽  
Food Preference ◽  
Smell Function ◽  
Taste And Smell

The impact of taste and smell alterations on quality of life in head and neck cancer patients

2015 ◽  
Vol 25 (6) ◽  
pp. 1495-1504 ◽  
Author(s):  
M. Alvarez-Camacho ◽  
S. Gonella ◽  
S. Ghosh ◽  
C. Kubrak ◽  
R. A. Scrimger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
The Impact ◽  
Taste And Smell

scholarly journals Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kristina S. Fluitman ◽  
Tim J. van den Broek ◽  
Max Nieuwdorp ◽  
Marjolein Visser ◽  
Richard G. IJzerman ◽  
...  
Keyword(s):  
Older Adults ◽  
Alpha Diversity ◽  
Oral Microbiota ◽  
Microbial Composition ◽  
Cross Sectional ◽  
Poor Appetite ◽  
Identification Score ◽  
Smell Function ◽  
Taste And Smell ◽  
Smell Identification

AbstractPoor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.

Taste and smell function in chronic disease:

2013 ◽  
Vol 34 (5) ◽  
pp. 477-489 ◽  
Author(s):  
Robert I. Henkin ◽  
Lucien M. Levy ◽  
April Fordyce
Keyword(s):  
Chronic Disease ◽  
Smell Function ◽  
Taste And Smell

scholarly journals cAMP and cGMP in nasal mucus: relationships to taste and smell dysfunction, gender and age

2008 ◽  
Vol 31 (2) ◽  
pp. 71 ◽  
Author(s):  
R I Henkin ◽  
I Velicu
Keyword(s):  
Olfactory Receptor ◽  
Normal Subjects ◽  
Feedback Mechanism ◽  
Nasal Mucus ◽  
Normal Women ◽  
And Gender ◽  
Normal Men ◽  
Smell Function ◽  
Camp And Cgmp ◽  
Taste And Smell

Purpose: To evaluate the presence and concentration of cAMP and cGMP in human nasal mucus in normal volunteers, to relate these findings to age and gender, and to compare normal levels with those in patients with taste and smell dysfunction. Methods: Nasal mucus was collected over one to four days in 66 normal subjects and 203 patients with smell loss (hyposmia). Samples were centrifuged at 20,000 rpm, the supernatant removed and analyzed for cAMP and cGMP by using a 96 plate technique with a specific spectrophotometric colorimetric ELISA assay. Results: Both cAMP and cGMP were present in human nasal mucus with both cAMP and cGMP significantly higher in normal women than in normal men [men vs. women; cAMP, 0.23±0.002 vs. 0.34±0.05 (P < 0.05); cGMP, 0.28±0.03 vs. 0.63±0.12 (P < 0.01)]. Both cAMP and cGMP changed with age; both moieties increased in a U shaped, parabolic pattern reaching a peak at age 41-50 with cAMP diminishing thereafter and then increasing to its highest level over age 70. Both cAMP and cGMP were lower in patients with taste and smell dysfunction than in normal subjects [normals vs. patients; cAMP, 0.31±0.05 vs. 0.15±0.02 (P < 0.01); cGMP, 0.56±0.07 vs. 0.025±0.02 (P < 0.001)] suggesting a relationship to olfactory pathology. Conclusions: This is the first definitive study to demonstrate the presence of these cyclic nucleotides in nasal mucus and the first to reveal decreased levels in patients with impaired taste and smell function. Since olfactory receptor sensitivity decreases with age increased nasal mucus cAMP over age 70 may appear incongruous but suggests one role of cAMP in olfactory function may relate to feedback mechanism(s) whereby its increase over age 70 yr reflects a physiological attempt to enhance diminishing lfactory function through growth and development of olfactory receptor activity.

Chemotherapy alters subjective senses of taste and smell but not dietary patterns in Japanese lung cancer patients

2019 ◽  
Vol 28 (4) ◽  
pp. 1667-1674
Author(s):  
Nao Yoshimoto ◽  
Masaharu Inagaki ◽  
Yoshie Sekiguchi ◽  
Yoko Tomishima ◽  
Kayo Masuko
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Dietary Patterns ◽  
Lung Cancer Patients ◽  
Taste And Smell
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