Vitamin B6 Modulation of Steroid Receptor-mediated Gene Expression

1994 ◽  
pp. 319-327 ◽  
Author(s):  
Douglas B. Tully ◽  
Alyson B. Scoltock ◽  
John A. Cidlowski
Keyword(s):  
Gene Expression ◽  
Vitamin B6 ◽  
Steroid Receptor

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain

Cell ◽  
1988 ◽  
Vol 52 (5) ◽  
pp. 685-695 ◽  
Author(s):  
Stuart Adler ◽  
Marian L. Waterman ◽  
Xi He ◽  
Michael G. Rosenfeld
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Steroid Receptor ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Prolactin Gene

Vitamin B6 Modulation of Steroid-Induced Gene Expression

2018 ◽  
pp. 547-567
Author(s):  
Douglas Β. Tully ◽  
Victoria E. Allgood ◽  
John A. Cidlowski
Keyword(s):  
Gene Expression ◽  
Vitamin B6

scholarly journals Vitamin B6 activates p53 and elevates p21 gene expression in cancer cells and the mouse colon

2014 ◽  
Vol 31 (5) ◽  
pp. 2371-2376 ◽  
Author(s):  
PEIPEI ZHANG ◽  
SOFYA SUIDASARI ◽  
TOMOMI HASEGAWA ◽  
NORIYUKI YANAKA ◽  
NORIHISA KATO
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Vitamin B6 ◽  
Mouse Colon

scholarly journals Endometrial Endothelial Cell Steroid Receptor Expression and Steroid Effects on Gene Expression

2005 ◽  
Vol 90 (3) ◽  
pp. 1812-1818 ◽  
Author(s):  
Graciela Krikun ◽  
Frederick Schatz ◽  
Robert Taylor ◽  
Hilary O. D. Critchley ◽  
Peter A. W. Rogers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cell ◽  
Steroid Receptor ◽  
Receptor Expression ◽  
Steroid Receptor Expression

279. Expression of oestrogen receptor-α and modulators of steroid receptor signalling, proline-rich nuclear receptor-2 and peptidylprolyl isomerade-D, in the hypothalamus of suckled and weaned postpartum beef cows

2008 ◽  
Vol 20 (9) ◽  
pp. 79
Author(s):  
T. Flatscher-Bader ◽  
A. H. M. Suhaimi ◽  
SA Lehnert ◽  
A. Reverter ◽  
W. Barris ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Receptor ◽  
Oestrogen Receptor ◽  
Arcuate Nucleus ◽  
Gene Clusters ◽  
Steroid Receptor ◽  
Beef Cows ◽  
Hypothalamic Nucleus ◽  
Receptor Signalling ◽  
Oestrogen Receptor Α

The aim was to characterise gene expression in the hypothalamus of suckled and weaned postpartum beef cows. The hypothalamus was obtained at slaughter from 12 primiparous Brahman cows (Zebu, Bos indicus) at 27 and 34 days postpartum. Six cows were weaned 7 days or 14 days before slaughter. Hypothalamic regions used for gene expression were: H1 (SC-POA, APVN, anterior hypothalamic nucleus, anterior portion of the arcuate nucleus, nearby areas of the diagonal band of Broca, and medial septum); H2 (basal hypothalamus-median eminence, ventromedial hypothalamus, posterior portion of the arcuate nucleus, and anterior part of the mammillary body). Gene expression was determined using the Agilent bovine 44k DNA microarray and differential expression (DE) was ascertained by mixed model analysis. A total of 122 genes were DE in H1 and 84 genes were DE in H2; 41 DE genes were common to H1 and H2. Functional clustering of DE genes using DAVID (www.david.abcc.ncifcrf.gov) revealed DE gene clusters in H1 associated with signalling events and ion binding, and DE gene clusters in H2 associated with hormone activity and ligand-receptor interactions. Of the DE genes, ~25% were linked with oestrogen signalling. This included oestrogen receptor-α (ESR1) that showed lower DE in H2 for weaned cows. Two modulators of steroid receptor signalling, proline-rich nuclear receptor coactivator-2 (PNRC2)1 and peptidylprolyl isomerase D (PPID)2, showed altered expression. In weaned cows, expression level of PNRC2 was lower in H1 and H2, while that of PPID was decreased in H1. The overlapped hypothalamic regions H1 and H2 are known to contain GnRH neuron terminals and kisspeptin neurons. Weaning promotes the resumption of cyclic ovarian function in postpartum cows, and the similar shifts in DE of ESR1, PNRC2 and PPID provided further evidence of a role for oestradiol at the hypothalamus in regulating postpartum reproduction. (1) Zhou D et al. 2006 Nucleic Acids Res 34:5974–86 (2) Kumar P et al. 2001 Biochem Biophys Res Commun 284:219–25

Uterine myoma and adenomyosis: molecular characterization by steroid receptor gene expression

2018 ◽  
Vol 4_2018 ◽  
pp. 58-63
Author(s):  
Shramko S.V. Shramko ◽  
Gulyaeva L.F. Gulyaeva ◽  
Bazhenova L.G. Bazhenova ◽  
Levchenko V.G. Levchenko ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Characterization ◽  
Receptor Gene ◽  
Steroid Receptor ◽  
Uterine Myoma ◽  
Receptor Gene Expression

Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily

Endocrine ◽  
1995 ◽  
Vol 3 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Ritsuro Ideta ◽  
Shuyuan Yeh ◽  
Yifen Lee ◽  
Kenji Adachi ◽  
Hiroyuki Takeda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Steroid Receptor ◽  
Orphan Receptor

scholarly journals Attenuation of Glucocorticoid Signaling through Targeted Degradation of p300 via the 26S Proteasome Pathway

2002 ◽  
Vol 16 (12) ◽  
pp. 2819-2827 ◽  
Author(s):  
Qiao Li ◽  
Anna Su ◽  
Jihong Chen ◽  
Yvonne A. Lefebvre ◽  
Robert J. G. Haché
Keyword(s):  
Gene Expression ◽  
Glucocorticoid Receptor ◽  
Sodium Butyrate ◽  
Steroid Receptor ◽  
26S Proteasome ◽  
Regulatory Control ◽  
Specific Gene ◽  
Control Of Gene Expression ◽  
Steroid Receptor Coactivator ◽  
Proteasome Pathway

Abstract The effects of acetylation on gene expression are complex, with changes in chromatin accessibility intermingled with direct effects on transcriptional regulators. For the nuclear receptors, both positive and negative effects of acetylation on specific gene transcription have been observed. We report that p300 and steroid receptor coactivator 1 interact transiently with the glucocorticoid receptor and that the acetyltransferase activity of p300 makes an important contribution to glucocorticoid receptor-mediated transcription. Treatment of cells with the deacetylase inhibitor, sodium butyrate, inhibited steroid-induced transcription and altered the transient association of glucocorticoid receptor with p300 and steroid receptor coactivator 1. Additionally, sustained sodium butyrate treatment induced the degradation of p300 through the 26S proteasome pathway. Treatment with the proteasome inhibitor MG132 restored both the level of p300 protein and the transcriptional response to steroid over 20 h of treatment. These results reveal new levels for the regulatory control of gene expression by acetylation and suggest feedback control on p300 activity.

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