Gene therapy for inflammatory diseases of the salivary glands

Obstructive and inflammatory diseases of the salivary glands can have a congenital, traumatic, metabolic, or infectious-inflammatory cause. The acute inflammatory conditions include bacterial and viral infections, and the chronic conditions include sialoliths, strictures, chronic sialadenitis, sialectasis, and lymphoepithelial disease. The neoplastic diseases can cause obstruction and/or infection and often make the diagnosis elusive. In addition to a working knowledge of possible etiology, one needs experience with clinical examination, salivary analysis, sialography, CT scans, MRI, and fine-needle aspiration and cytology in order successfully to evaluate and manage patients with these conditions.

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Inflammatory and Obstructive Disorders of Salivary Glands

Journal of Dental Research ◽

10.1177/00220345870660s212 ◽

1987 ◽

Vol 66 (2_suppl) ◽

pp. 675-679 ◽

Cited By ~ 11

Author(s):

A. Blitzer

Keyword(s):

Salivary Glands ◽

Fine Needle Aspiration ◽

Chronic Conditions ◽

Viral Infections ◽

Inflammatory Diseases ◽

Needle Aspiration ◽

Ct Scans ◽

Fine Needle ◽

Inflammatory Conditions ◽

Chronic Sialadenitis

Obstructive and inflammatory diseases of the salivary glands can have a congenital, traumatic, metabolic, or infectious-inflammatory cause. The acute inflammatory conditions include bacterial and viral infections, and the chronic conditions include sialoliths, strictures, chronic sialadenitis, sialectasis, and lymphoepithelial disease. The neoplastic diseases can cause obstruction and/or infection and often make the diagnosis elusive. In addition to a working knowledge of possible etiology, one needs experience with clinical examination, salivary analysis, sialography, CT scans, MRI, and fine-needle aspiration and cytology in order successfully to evaluate and manage patients with these conditions.

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Gene therapy in inflammatory diseases – are we there yet?

Molecular Medicine Today ◽

10.1016/s1357-4310(00)01764-0 ◽

2000 ◽

Vol 6 (9) ◽

pp. 341

Author(s):

George C Tsokos

Keyword(s):

Gene Therapy ◽

Inflammatory Diseases

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Inflammatory diseases of the salivary glands in infants and adolescents

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2005.06.012 ◽

2006 ◽

Vol 70 (1) ◽

pp. 129-136 ◽

Cited By ~ 14

Author(s):

R. Laskawi ◽

F. Schaffranietz ◽

C. Arglebe ◽

M. Ellies

Keyword(s):

Salivary Glands ◽

Inflammatory Diseases

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RADIATION METHODS FOR DIAGNOSIS OF SALIVARY GLAND DISEASES. REVIEW

Medical Science of Ukraine (MSU) ◽

10.32345/2664-4738.1-2.2017.16 ◽

2017 ◽

Vol 13 (1-2) ◽

pp. 113-121

Author(s):

T.V. Topchiy ◽

D.V. Topchiy

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Malignant Tumors ◽

Inflammatory Diseases ◽

Diagnostic Methods ◽

Salivary Gland Diseases ◽

Methods Development ◽

Ultrasound Diagnostics ◽

History Of ◽

Diagnostic Capabilities

In modern conditions, the application of radiodiagnosis of salivary gland diseases requires a profound knowledge of the physical and technical bases and their scientific and methodological peculiarities. There are presented information on the history of discovery and diagnostic capabilities of some methods of radiation diagnosis. Analogue sialography at a certain stage of the application gave clinicians valuable information. In the diagnosis of inflammatory diseases, there is a predominance of traditional sialogram. The functional digital subtraction sialography allow us to eliminate traditional sialogram disadvantages. This method is considered the gold standard for the diagnosis of salivary ducts. Computer tomographic sialography is the most valuable for the diagnosis of salivary gland tumors, allows differential diagnosis between benign and malignant tumors. An important advantage of salivary gland scintigraphy in comparison with other imaging methods is that both the secretory function and the excretory fraction of all four major salivary glands. Glands can be simultaneously quantified using a single injection. The method of ultrasound diagnostics allows to detect both malformations and inflammatory, degenerative-dystrophic processes, has some clear advantages in comparison with sialography, scintigraphy, computed tomography, since neither x-ray nor magnetic field is used, the duration of the procedure is shortened, the tomographic plane can be easily manipulated, metal bodies do not interfere. Conclusion. Complex application of radiation diagnostic methods, development of algorithms for the diagnosis of salivary glands can become a source of accurate and practically meaningful information.

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