Reactive oxygen species-responsive nanoplatforms for nucleic acid-based gene therapy of cancer and inflammatory diseases

2021 ◽  
Author(s):  
Dandan Zhu ◽  
Wang Chen ◽  
Wenyi Lin ◽  
Ying Li ◽  
Xiaoxuan Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Therapy ◽  
Nucleic Acid ◽  
Inflammatory Diseases ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Reactive Oxygen Species, Apoptosis, Antimicrobial Peptides and Human Inflammatory Diseases

2015 ◽  
Vol 8 (2) ◽  
pp. 151-175 ◽  
Author(s):  
Babatunji Oyinloye ◽  
Abiola Adenowo ◽  
Abidemi Kappo
Keyword(s):  
Reactive Oxygen Species ◽  
Antimicrobial Peptides ◽  
Inflammatory Diseases ◽  
Reactive Oxygen ◽  
Oxygen Species

Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer

2018 ◽  
Vol 10 (50) ◽  
pp. 43352-43362 ◽  
Author(s):  
Jiajia Xiang ◽  
Xin Liu ◽  
Zhuxian Zhou ◽  
Dingcheng Zhu ◽  
Quan Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Therapy ◽  
Metastatic Cancer ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals APOCYNIN, AN INHIBITOR OF THE NADPH OXIDASE COMPLEX

2020 ◽  
Vol 17 (34) ◽  
pp. 478-501
Author(s):  
Camila Nascimento GIONGO ◽  
Vanessa Falchetti LOPES ◽  
Diana Fortkamp GRIGOLETTO ◽  
Eduardo Hösel MIRANDA
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Superoxide Anion ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Reactive Oxygen ◽  
Enzyme Complex ◽  
Oxygen Species ◽  
Phagocytic Cells ◽  
Oxidative Species

Apocynin is a phenolic compound isolated from the plant Picrorhiza kurroa Royle ex Benth. Such a compound has been extensively investigated for its therapeutic potential in diseases involving inflammatory processes or oxidative stress due to its ability to inhibit the NADPH oxidase multienzyme complex. This complex consists of two transmembrane proteins (Nox2 and p22phox) and four cytosolic regulatory proteins (p67phox, p47phox, p40phox, and GTPase-Rac) and their activation occurs after the stimulation of phagocytic cells by the mediation of the enzyme myeloperoxidase (MPO). NADPH oxidase is the only enzyme complex that is intended for the production of superoxide anion that is precursor of highly oxidizing substances classified as reactive oxygen species (ROS). NADPH oxidase is an enzyme complex that produces superoxide anion from molecular oxygen. Ta the same time, the superoxide anion is a precursor to reactive oxygen species (ROS) catalyzed by enzymes.These oxidative species, when in excess, can induce burst, causing irreparable tissue damage. They can act by modifying the redox state of DNA, protein or lipid molecules, playing a central role in the development of chronic pathologies and various health complications. One can cite vascular problems, hyperglycemia, diabetes, hypertension, Alzheimer's disease, and cancer, among others. Apocynin, previously activated by MPO, blocks the enzyme complex and prevents the formation of these oxidative species. Therefore, the central biological function of compound is to modulate the action of NADPH oxidase, promoting a positive effect in the prevention/remediation of inflammatory diseases.

scholarly journals Reactive Oxygen Species (ROS) and Nucleic Acid Modifications during Seed Dormancy

Plants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 679 ◽  
Author(s):  
Kai Katsuya-Gaviria ◽  
Elena Caro ◽  
Néstor Carrillo-Barral ◽  
Raquel Iglesias-Fernández
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Dna Methylation ◽  
Nucleic Acid ◽  
Seed Development ◽  
Seed Dormancy ◽  
Biological Significance ◽  
Reactive Oxygen ◽  
Epigenetic Mechanism ◽  
Oxygen Species

The seed is the propagule of higher plants and allows its dissemination and the survival of the species. Seed dormancy prevents premature germination under favourable conditions. Dormant seeds are only able to germinate in a narrow range of conditions. During after-ripening (AR), a mechanism of dormancy release, seeds gradually lose dormancy through a period of dry storage. This review is mainly focused on how chemical modifications of mRNA and genomic DNA, such as oxidation and methylation, affect gene expression during late stages of seed development, especially during dormancy. The oxidation of specific nucleotides produced by reactive oxygen species (ROS) alters the stability of the seed stored mRNAs, being finally degraded or translated into non-functional proteins. DNA methylation is a well-known epigenetic mechanism of controlling gene expression. In Arabidopsis thaliana, while there is a global increase in CHH-context methylation through embryogenesis, global DNA methylation levels remain stable during seed dormancy, decreasing when germination occurs. The biological significance of nucleic acid oxidation and methylation upon seed development is discussed.

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