Timing of Serum Soluble HLA-G Levels in Acute and Subacute Phases After Spontaneous Intracerebral Hemorrhage

2009 ◽  
pp. 141-145 ◽  
Author(s):  
Enrico Fainardi ◽  
Roberta Rizzo ◽  
Angelica Lupato ◽  
Vania Ramponi ◽  
Giuseppe De Santis ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Soluble Hla

Spontaneous Intracerebral Hemorrhage in the Elderly Population

2018 ◽  
Author(s):  
S. Sommaruga ◽  
R. Beekman ◽  
S. Chu ◽  
Z. King ◽  
C. Matouk ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Elderly Population ◽  
The Elderly ◽  
Spontaneous Intracerebral Hemorrhage

Spontaneous intracerebral hemorrhage in a child with systemic hypertension and adrenal adenoma

2007 ◽  
Vol 107 (4) ◽  
pp. 328-329
Author(s):  
Oszkar Szentirmai ◽  
Ken R. Winston ◽  
Paul Jedlicka ◽  
Gary M. Lum
Keyword(s):  
Intracerebral Hemorrhage ◽  
Adrenal Adenoma ◽  
Systemic Hypertension ◽  
Spontaneous Intracerebral Hemorrhage

A systematic review and meta-analysis of antiepileptic prophylaxis in spontaneous intracerebral hemorrhage

2021 ◽  
Author(s):  
Michael J. Gigliotti ◽  
David D. Wilkinson ◽  
Scott D. Simon ◽  
Kevin M. Cockroft ◽  
Ephraim W. Church
Keyword(s):  
Systematic Review ◽  
Intracerebral Hemorrhage ◽  
Meta Analysis ◽  
Spontaneous Intracerebral Hemorrhage

Surgical Management of Spontaneous Intracerebral Hemorrhage

2021 ◽  
Vol 23 (8) ◽  
Author(s):  
Sandeep Walia ◽  
Kirsten Fisher ◽  
Robert L. Dodd ◽  
Chitra Venkatasubramanian
Keyword(s):  
Intracerebral Hemorrhage ◽  
Surgical Management ◽  
Spontaneous Intracerebral Hemorrhage

scholarly journals Anti-inflammatory genes in PBMCs post-spontaneous intracerebral hemorrhage

2021 ◽  
Vol 12 (1) ◽  
pp. 58-66
Author(s):  
Doan Nguyen ◽  
Vi Tran ◽  
Alireza Shirazian ◽  
Cruz Velasco-Gonzalez ◽  
Ifeanyi Iwuchukwu
Keyword(s):  
Intracerebral Hemorrhage ◽  
Negative Correlation ◽  
Mononuclear Cells ◽  
Inflammatory Cells ◽  
Favorable Outcome ◽  
Hospital Length Of Stay ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Hematoma Volume ◽  
Peripheral Blood Mononuclear ◽  
Anti Inflammatory

Abstract Background Neuroinflammation is important in the pathophysiology of spontaneous intracerebral hemorrhage (ICH) and peripheral inflammatory cells play a role in the clinical evolution and outcome. Methodology Blood samples from ICH patients (n = 20) were collected at admission for 5 consecutive days for peripheral blood mononuclear cells (PBMCs). Frozen PBMCs were used for real-time PCR using Taqman probes (NFKB1, SOD1, PPARG, IL10, NFE2L2, and REL) and normalized to GAPDH. Data on hospital length of stay and modified Rankin score (MRS) were collected with 90-day MRS ≤ 3 as favorable outcome. Statistical analysis of clinical characteristics to temporal gene expression from early to delayed timepoints was compared for MRS groups (favorable vs unfavorable) and hematoma volume. Principle findings and results IL10, SOD1, and REL expression were significantly higher at delayed timepoints in PBMCs of ICH patients with favorable outcome. PPARG and REL increased between timepoints in patients with favorable outcome. NFKB1 expression was not sustained, but significantly decreased from higher levels at early onset in patients with unfavorable outcome. IL10 expression showed a negative correlation in patients with high hematoma volume (>30 mL). Conclusions and significance Anti-inflammatory, pro-survival regulators were highly expressed at delayed time points in ICH patients with a favorable outcome, and IL10 expression showed a negative correlation to high hematoma volume.

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