Highly Integrated, Low Cost, Palm-Top Sized Magnetic Resonance Relaxometry System for Rapid Blood Screening

Author(s):  
Nhat Nguyen Vo ◽  
Lan Chen ◽  
Xuening Liu ◽  
Weng Kung Peng ◽  
Zhou Yi Ming ◽  
...  
2018 ◽  
Vol 49 (1) ◽  
pp. 1-19
Author(s):  
Michele Capurso ◽  
Corrado Rossetti ◽  
Luca Mutti ◽  
Anita Ciani ◽  
Valerio Santangelo

1989 ◽  
Vol 37 (3-4) ◽  
pp. 121-122
Author(s):  
S. Pittard ◽  
R.E. Ellis ◽  
M.E. Fry ◽  
R. Jacoby ◽  
E.A. Moore ◽  
...  

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Laurence Klotz ◽  
Giovanni Lughezzani ◽  
Davide Maffei ◽  
Andrea Sanchez ◽  
Jose Gregorio Pereira ◽  
...  

Introduction: High-resolution micro-ultrasound has the capability of imaging prostate cancer based on detecting alterations in ductal anatomy, analogous to multiparametric magnetic resonance imaging (mpMRI). This technology has the potential advantages of relatively low cost, simplicity, and accessibility compared to mpMRI. This multicenter, prospective registry aims to compare the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of mpMRI with high-resolution micro-ultrasound imaging for the detection of clinically significant prostate cancer. Methods: We included 1040 subjects at 11 sites in seven countries who had prior mpMRI and underwent ExactVu micro-ultrasound-guided biopsy. Biopsies were taken from both mpMRI targets (PI-RADS >3 and micro-ultrasound targets (PRIMUS >3). Systematic biopsies (up to 14 cores) were also performed. Various strategies were used for mpMRI target sampling, including cognitive fusion with micro-ultrasound, separate software-fusion systems, and software-fusion using the micro-ultrasound FusionVu system. Clinically significant cancer was those with Gleason grade group ≥2. Results: Overall, 39.5% were positive for clinically significant prostate cancer. Micro-ultrasound and mpMRI sensitivity was 94% vs. 90%, respectively (p=0.03), and NPV was 85% vs. 77%, respectively. Specificities of micro-ultrasound and MRI were both 22%, with similar PPV (44% vs. 43%). This represents the initial experience with the technology at most of the participating sites and, therefore, incorporates a learning curve. Number of cores, diagnostic strategy, blinding to MRI results, and experience varied between sites. Conclusions: In this initial multicenter registry, micro-ultrasound had comparable or higher sensitivity for clinically significant prostate cancer compared to mpMRI, with similar specificity. Micro-ultrasound is a low-cost, single-session option for prostate screening and targeted biopsy. Further larger-scale studies are required for validation of these findings.


1989 ◽  
Vol 22 (8) ◽  
pp. 574-582 ◽  
Author(s):  
S Pittard ◽  
M E Fry ◽  
R E Ellis ◽  
E A Moore ◽  
W Vennart

2017 ◽  
Vol 12 (2) ◽  
pp. 021005 ◽  
Author(s):  
Saowalak Krungchanuchat ◽  
Titipun Thongtem ◽  
Somchai Thongtem ◽  
Chalermchai Pilapong

2014 ◽  
Vol 8 (4) ◽  
Author(s):  
Omid Forouzan ◽  
Evan Flink ◽  
Jared Warczytowa ◽  
Nick Thate ◽  
Andrew Hanske ◽  
...  

Cardiovascular disease is the leading cause of death worldwide. Many cardiovascular diseases are better diagnosed during a cardiac stress test. Current approaches include either exercise or pharmacological stress echocardiography and pharmacological stress magnetic resonance imaging (MRI). MRI is the most accurate noninvasive method of assessing cardiac function. Currently there are very few exercise devices that allow collection of cardiovascular MRI data during exercise. We developed a low-cost exercise device that utilizes adjustable weight resistance and is compatible with magnetic resonance (MR) imaging. It is equipped with electronics that measure power output. Our device allows subjects to exercise with a leg-stepping motion while their torso is in the MR imager. The device is easy to mount on the MRI table and can be adjusted for different body sizes. Pilot tests were conducted with 5 healthy subjects (3 male and 2 female, 29.2 ± 3.9 yr old) showing significant exercise-induced changes in heart rate (+42%), cardiac output (+40%) and mean pulmonary artery (PA) flow (+%49) post exercise. These data demonstrate that our MR compatible stepper exercise device successfully generated a hemodynamically stressed state while allowing for high quality imaging. The adjustable weight resistance allows exercise stress testing of subjects with variable exercise capacities. This low-cost device has the potential to be used in a variety of pathologies that require a cardiac stress test for diagnosis and assessment of disease progression.


Nowa Medycyna ◽  
2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Jacek Piłat ◽  
Sławomir Rudzki ◽  
Jacek Bicki ◽  
Wojciech Dąbrowski

The authors present issues related to the diagnosis of the most common inflammatory diseases of the anus. They deal with anal fistulas and abscesses in a special way. They present various diagnostic methods: from basic proctological examination to instrumental methods. They asses the usefulness, disadvantages and limitations of individual methods. The highest assessment of the presented diagnostic methods was obtained by two tests, i.e. magnetic resonance imaging and endosonographic examination in the 3D option, supported by the use of the render mode option or hydrogen peroxide as a contrast agent. In a sense, both examinations are comparable when it comes to inflammatory diseases of the anus. For endosonographic examination, the advantage is low cost, repeatability and availability. The disadvantage of magnetic resonance imaging is the high price of the test, the low availability and possible claustrophobia of the patient or the presence of metal implants. However, the undeniable advantage of magnetic resonance imaging is the ability to assess anal fistulas or abscesses located high above the levator muscles. In the assessment of deeply located lesions, the advantage of magnetic resonance results from the shorter focus of the endosonographic probe. The high frequency of the probe gives good image quality, but it is paid for the shorter penetration of the ultrasound rays. The use of the render mode or contrast – hydrogen peroxide option puts the endosonographic examination in a one row with magnetic resonance imaging in the diagnosis of the most frequent occurring fistulas and abscesses. Considering lower costs, repeatability of the endosonographic examination it is a valuable modern instrument in the diagnosis of inflammatory lesions of the anus.


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