Developing a Novel Method Based on Orthogonal Polynomial Equation to Approximate the Solution of Agent Based Model for the Immune System Simulation

2015 ◽  
pp. 819-824
Author(s):  
Xuming Tong ◽  
Meijing Kong ◽  
Edwin Tawanda Mudzingwa ◽  
Le Zhang
Keyword(s):  
Immune System ◽  
Orthogonal Polynomial ◽  
System Simulation ◽  
Polynomial Equation ◽  
Agent Based Model ◽  
Agent Based ◽  
Novel Method

An enhanced agent based model of the immune system response

2006 ◽  
Vol 244 (2) ◽  
pp. 77-79 ◽  
Author(s):  
V. Baldazzi ◽  
F. Castiglione ◽  
M. Bernaschi
Keyword(s):  
Immune System ◽  
System Response ◽  
Agent Based Model ◽  
Agent Based ◽  
Immune System Response

Agent-Based Model of the Endocrine Pancreas and Interaction with Innate Immune System

2010 ◽  
pp. 157-164
Author(s):  
Ignacio V. Martínez Espinosa ◽  
Enrique J. Gómez Aguilera ◽  
María E. Hernando Pérez ◽  
Ricardo Villares ◽  
José Mario Mellado García
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Endocrine Pancreas ◽  
Innate Immune ◽  
Agent Based Model ◽  
Agent Based

scholarly journals An agent-based model of avascular tumor growth: Immune response tendency to prevent cancer development

SIMULATION ◽  
2017 ◽  
Vol 93 (8) ◽  
pp. 641-657 ◽  
Author(s):  
Fateme Pourhasanzade ◽  
S.H Sabzpoushan ◽  
Ali Mohammad Alizadeh ◽  
Ebrahim Esmati
Keyword(s):  
Immune System ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Immune Cells ◽  
Computational Models ◽  
Growth Fraction ◽  
Agent Based Model ◽  
Agent Based ◽  
Clinical Experiments ◽  
Avascular Tumor

Mathematical and computational models are of great help to study and predict phenomena associated with cancer growth and development. These models may lead to introduce new therapies or improve current treatments by discovering facts that may not be easily discovered in clinical experiments. Here, a new two-dimensional (2D) stochastic agent-based model is presented for the spatiotemporal study of avascular tumor growth based on the effect of the immune system. The simple decision-making rules of updating the states of each agent depend not only on its intrinsic properties but also on its environment. Tumor cells can interact with both normal and immune cells in their Moore neighborhood. The effect of hypoxia has been checked off by considering non-mutant proliferative tumor cells beside mutant ones. The recruitment of immune cells after facing a mass of tumor is also considered. Results of the simulations are presented before and after the appearance of immune cells in the studied tissue. The growth fraction and necrotic fraction are used as output parameters along with a 2D graphical growth presentation. Finally, the effect of input parameters on the output parameters generated by the model is discussed. The model is then validated by an in vivo study published in medical articles. The results show a multi-spherical tumor growth before the immune system strongly involved in competition with tumor cells. Besides, considering the immune system in the model shows more compatibility with biological facts. The effect of the microenvironment on the proliferation of cancer and immune cells is also studied.

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