Diminished 1,25-Dihydroxyvitamin D with Preserved 25-Hydroxyvitamin D Levels in 10–18-Year-Old Youth with New-Onset Type 1 Diabetes

2016 ◽  
pp. 115-126
Author(s):  
Jefte M. Drijvers ◽  
Elisa Giani ◽  
Lisa K. Volkening ◽  
Lori M. Laffel
Keyword(s):  
Type 1 Diabetes ◽  
Onset Type ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
New Onset

scholarly journals Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2048
Author(s):  
Clare B. Kelly ◽  
Carol L. Wagner ◽  
Judith R. Shary ◽  
Misti J. Leyva ◽  
Jeremy Y. Yu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Binding Protein ◽  
Vitamin D Metabolites ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
Healthy Pregnancy ◽  
25 Hydroxyvitamin D

The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks’ gestation (“Visits” (V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p < 0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p < 0.01) and V3 (bioavailable: p < 0.05; free: p < 0.01), lower concentrations of VDBP at V3 (p < 0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p < 0.01) and 1,25(OH)2D/25(OH)D (V3, p < 0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis.

16-OR: Codesigning an Intervention for Adults with New-Onset Type 1 Diabetes to Improve Psychological and Social Adaptation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 16-OR
Author(s):  
METTE DUE-CHRISTENSEN ◽  
LENE E. JOENSEN ◽  
SOPHIE SARRE ◽  
JULIE L. WAD ◽  
EWA ROMANCZUK ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Social Adaptation ◽  
Onset Type ◽  
New Onset

scholarly journals Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan

2021 ◽  
Author(s):  
Yuichi Nishioka ◽  
Tatsuya Noda ◽  
Sadanori Okada ◽  
Tomoya Myojin ◽  
Shinichiro Kubo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Incidence Rate ◽  
Onset Type ◽  
New Onset

scholarly journals The potential effect of metabolic alkalosis on insulin sensitivity in an adolescent with new‐onset type 1 diabetes

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
William E. Novotny ◽  
Irma Fiordalisi ◽  
Cynthia P. Keel ◽  
Glenn D. Harris
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Metabolic Alkalosis ◽  
Potential Effect ◽  
Onset Type ◽  
New Onset
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