Muscle Relaxants | ScienceGate

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

Download Full-text

Effective Atomic Number, Electron Density and CT Numbers of Skeletal Muscle Relaxants for Imaging

International Journal of Scientific Research in Physics and Applied Sciences ◽

10.26438/ijsrpas/v6i6.116121 ◽

2018 ◽

Vol 6 (6) ◽

pp. 116-121

Author(s):

Suresh K C ◽

Sathish KN

Keyword(s):

Skeletal Muscle ◽

Electron Density ◽

Atomic Number ◽

Effective Atomic Number ◽

Muscle Relaxants

Download Full-text

The combination of naproxen with triptans, gabapentin, pregabalin and muscle relaxants

INTERNATIONAL NEUROLOGICAL JOURNAL ◽

10.22141/2224-0713.1.87.2017.96540 ◽

2017 ◽

Vol 0 (1.87) ◽

pp. 75-79

Author(s):

N.K. Svyrydova

Keyword(s):

Muscle Relaxants

Download Full-text

Nondepolarizing muscle relaxants for surgery in myasthenic patients

10.1002/14651858.cd006582.pub2 ◽

2009 ◽

Author(s):

Idoris Cordero Escobar ◽

Javier Espinaco Vald��s ◽

Angela R Gutierrez Rojas ◽

Nicolas Parisi L��pez ◽

Rosa E Jimenez

Keyword(s):

Muscle Relaxants ◽

Nondepolarizing Muscle Relaxants

Download Full-text

Nondepolarizing muscle relaxants for surgery in myasthenic patients

10.1002/14651858.cd006582 ◽

2007 ◽

Author(s):

I Cordero Escobar ◽

J Espinaco Vald��s ◽

AR Gutierrez Rojas ◽

RE Jimenez Paneca ◽

N Parisi L��pez

Keyword(s):

Muscle Relaxants ◽

Nondepolarizing Muscle Relaxants

Download Full-text

Muscle Tone Assessment under General Anesthesia for Sjögren-Larsson Syndrome and Spasticity

Pediatric Neurosurgery ◽

10.1159/000514329 ◽

2021 ◽

Vol 56 (2) ◽

pp. 163-165

Author(s):

George Georgoulis ◽

Argyrios Dinopoulos ◽

Emmanouil Gkliatis

Keyword(s):

General Anesthesia ◽

Muscle Tone ◽

Muscle Relaxants ◽

Spastic Diplegia ◽

Case Presentation ◽

Neurosurgical Procedure ◽

Dorsal Rhizotomy ◽

Severe Spasticity ◽

Larsson Syndrome ◽

Rule Out

Introduction: Study of muscle tone in individuals with severe spasticity (Modified Asworth Scale – MAS:3) under general anesthesia can confirm or rule out the eventual necessity of the impending spasticity relieving ablative neurosurgery by observing the hypertonia reduction and passive range of motion expansion. Therefore, what we measure under muscle relaxants is practically a fixed deformity. Case Presentation: The study was performed on a girl with Sjögren-Larsson syndrome, presenting with icthyosis and spastic diplegia. Proposed intervention was Dorsal Rhizotomy. Under general anesthesia, with and without muscle relaxants, hypertonia was significantly reduced (MAS:1), but the angle of motion did not increase much. Conclusion: We decided not to perform such a neurosurgical procedure. In ambiguous situations, the proposed study can help in decision-making for spasticity treatment.

Download Full-text

Midazolam-Flumazenil Topical Anaesthesia for Microlaryngoscopy with Jet Ventilation

Anaesthesia and Intensive Care ◽

10.1177/0310057x9702500406 ◽

1997 ◽

Vol 25 (4) ◽

pp. 358-364

Author(s):

W. Rushatamukayanunt ◽

T. Tritrakarn

Keyword(s):

Treated Group ◽

Muscle Relaxants ◽

Total Intravenous Anaesthesia ◽

Topical Anaesthesia ◽

Parallel Study ◽

Jet Ventilation ◽

Double Blind ◽

Intravenous Anaesthesia ◽

Single Intravenous Injection ◽

High Incidence

A comparison between midazolam and midazolam-flumazenil for total intravenous anaesthesia in combination with topical anaesthesia and muscle relaxants was performed in a double-blind, parallel study in 40 patients scheduled for microlaryngoscopy with or without bronchoscopic procedures using jet ventilation with oxygen. A single intravenous injection of midazolam 0.3 mg/kg, lignocaine spray and muscle relaxants provided adequate anaesthesia and good operative conditions throughout the procedures, which took 20 to 30 minutes. Patients who had placebo at the end of the procedures had a longer recovery and a high incidence of airway obstruction (20%). Administration of flumazenil provided prompt awakening in 19 of 20 patients (95%) within five minutes, resulting in rapid and favourable recovery without resedation or other side-effects, while only three of 20 (15%) patients in the placebo-treated group had improved consciousness within five minutes. The simplicity and reliability of the midazolam-flumazenil technique is attractive. We consider it worthy of further investigation for wider application in clinical practice.

Download Full-text