scholarly journals Midazolam-Flumazenil Topical Anaesthesia for Microlaryngoscopy with Jet Ventilation

1997 ◽  
Vol 25 (4) ◽  
pp. 358-364
Author(s):  
W. Rushatamukayanunt ◽  
T. Tritrakarn
Keyword(s):  
Treated Group ◽  
Muscle Relaxants ◽  
Total Intravenous Anaesthesia ◽  
Topical Anaesthesia ◽  
Parallel Study ◽  
Jet Ventilation ◽  
Double Blind ◽  
Intravenous Anaesthesia ◽  
Single Intravenous Injection ◽  
High Incidence

A comparison between midazolam and midazolam-flumazenil for total intravenous anaesthesia in combination with topical anaesthesia and muscle relaxants was performed in a double-blind, parallel study in 40 patients scheduled for microlaryngoscopy with or without bronchoscopic procedures using jet ventilation with oxygen. A single intravenous injection of midazolam 0.3 mg/kg, lignocaine spray and muscle relaxants provided adequate anaesthesia and good operative conditions throughout the procedures, which took 20 to 30 minutes. Patients who had placebo at the end of the procedures had a longer recovery and a high incidence of airway obstruction (20%). Administration of flumazenil provided prompt awakening in 19 of 20 patients (95%) within five minutes, resulting in rapid and favourable recovery without resedation or other side-effects, while only three of 20 (15%) patients in the placebo-treated group had improved consciousness within five minutes. The simplicity and reliability of the midazolam-flumazenil technique is attractive. We consider it worthy of further investigation for wider application in clinical practice.

Effect of Doxycycline on Pre-Menstrual Syndrome: A Double-Blind Randomized Clinical Trial

1988 ◽  
Vol 16 (4) ◽  
pp. 270-279 ◽  
Author(s):  
A. Toth ◽  
M. L. Lesser ◽  
G. Naus ◽  
C. Brooks ◽  
D. Adams
Keyword(s):  
Anaerobic Bacteria ◽  
Treated Group ◽  
Endometrial Biopsy ◽  
Hormonal Changes ◽  
Double Blind ◽  
High Incidence ◽  
Symptom Scores ◽  
Group A ◽  
Infectious Aetiology

Thirty patients with well-defined symptoms of pre-menstrual syndrome were randomly treated with the antibiotic doxycycline or placebo. The antibiotic-treated group showed a highly significant reduction of symptoms. Subsequent antibiotic treatment of the original placebo group similarly diminished the symptoms in this group. A 6-month follow-up demonstrated that the improvement in symptom scores was permanent and independent from the presence of the antibiotic. Luteal phase endometrial biopsies showed a high incidence of out-of-phase endometrium. An unexpectedly high percentage of endometrial biopsy cultures yielded positive findings for mycoplasma, Chlamydia trachomatis and anaerobic bacteria. There were no characteristic hormonal changes in this study group. An infectious aetiology, possibly a sub-clinical endometrial or ovarian infection, behind certain cases of pre-menstrual syndrome is postulated.

Suloctidil: Review Of Its Antiplatelet And Antithrombotic Properties In Man

1981 ◽  
Author(s):  
F Van Stalle ◽  
G Lambelin
Keyword(s):  
Treated Group ◽  
Venous Occlusion ◽  
Striking Difference ◽  
Parallel Study ◽  
Double Blind ◽  
Regeneration Time ◽  
Model Studies ◽  
Artery Disease ◽  
Set Up ◽  
Induced Aggregation

Suloctidil(S.) - 1-(4-isopropylthiophenyl)-2n octylamino- propanol - is a vaso-active compound endowed with antiplatelet and antithrombotic properties.After administration to healthy volunteers it was found to inhibit thrombofax and collagen induced aggregation.In a double blind cross-over set up-S. 200 mg T.I.D. vs. placebo - the induction of circulating platelet aggregates by venous occlusion was highly significantly inhibited.Following positive results on P.S.T. in the baboon a.-v. shunt model, studies on P.S.T. were initiated in man: 23 patients with valvular prosthesis, all under coumarine therapy, were admitted to a double blind parallel study of 6 weeks duration cqnparing S. 200 mg T.I.D. (n=ll) to placebo (n=12). P.S.T. (51Cr-labeling) measured before and during the last week of the study, was unchanged in the placebo and significantly increased in the S. treated group. Similar results were obtained measuring platelet regeneration time according to a modified Stewart method in an open study (n=6) in valvular prosthesis and in a double blind parallel study (S. n=25; placebo n=27) in valvular prosthesis, coronary artery disease and myocardial infarction.In patients with obstructive arteriopathy (Fontaine II & III) inhibition of thrombine induced platelet M.D.A. production and reduction of increased βTG levels have been observed under S. therapy at rest and after ischemia.In 31 patients suffering from recurr. ven. thrombosis, admitted to a double blind cross-over study comparing S. 200 mg T.I.D. to placebo-2 periods of 3 months each - a striking difference in the clinical evolution (placebo 12 events, S. none) was paralleled by consistent changes in biological parameters such as platelet aggregation, PF4 and βTG.The results obtained in pharmacological as well as in efficacy studies have justified the initiation of larger scale trials to evaluate the compounds antithrombotic potential.

scholarly journals Total Intravenous Anaesthesia versus Inhalational Anaesthesia for Dental Day Surgery

1992 ◽  
Vol 20 (4) ◽  
pp. 475-478 ◽  
Author(s):  
B. L. Lim ◽  
T. C. Low
Keyword(s):  
Nitrous Oxide ◽  
Day Surgery ◽  
Total Intravenous Anaesthesia ◽  
Double Blind ◽  
Intravenous Anaesthesia ◽  
Reversal Time ◽  
Nitrous Oxide Anaesthesia ◽  
Oxide Anaesthesia ◽  
Inhalational Anaesthesia ◽  
To Receive

Fifty young healthy and unpremedicated patients scheduled for removal of impacted teeth were randomly allocated to receive either total intravenous anaesthesia with propofol or conventional thiopentone/isoflurane/nitrous oxide anaesthesia. A double-blind postoperative assessment showed the former group to have a shorter reversal time and faster recovery of faculties, i. e. speech, memory as well as ability to sit up and walk without assistance (P < 0.01). There was no incidence of hypotension and of awareness in either group. The incidence of headache, nausea and vomiting was higher in the thiopentone/isoflurane/nitrous oxide group.

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