The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder

2017 ◽  
pp. 135-158 ◽  
Author(s):  
Rong Zhang ◽  
Xin-Jie Xu ◽  
Hong-Feng Zhang ◽  
Song-Ping Han ◽  
Ji-Sheng Han
Keyword(s):  
Autism Spectrum Disorder ◽  
Animal Models ◽  
Arginine Vasopressin ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Autism Spectrum Disorder and miRNA: An Overview of Experimental Models.

2019 ◽  
Vol 9 (10) ◽  
pp. 265 ◽  
Author(s):  
Schepici ◽  
Cavalli ◽  
Bramanti ◽  
Mazzon
Keyword(s):  
Autism Spectrum Disorder ◽  
Animal Models ◽  
Social Interactions ◽  
Autism Spectrum ◽  
Experimental Models ◽  
Spectrum Disorder ◽  
Biological Processes ◽  
Predictive Tool ◽  
Regulate Gene Expression

Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by deficits in social interactions, communication, language, and in a limited repertoire of activities and interests. The etiology of ASD is very complex. Genetic, epigenetic, and environmental factors contribute to the onset of ASD. Researchers have shown that microRNAs (miRNAs) could be one of the possible causes associated with ASD. miRNAs are small noncoding mRNAs that regulate gene expression, and they are often linked to biological processes and implicated in neurodevelopment. This review aims to provide an overview of the animal models and the role of the different miRNAs involved in ASD. Therefore, the use of animal models that reproduce the ASD and the identification of miRNAs could be a useful predictive tool to study this disorder.

scholarly journals Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system

2016 ◽  
Vol 111 ◽  
pp. 323-334 ◽  
Author(s):  
Li Wang ◽  
Luis E.F. Almeida ◽  
Margaret Nettleton ◽  
Alfia Khaibullina ◽  
Sarah Albani ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Animal Models ◽  
Cholinergic System ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Nocifensive Behavior

scholarly journals Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
María del Pilar Madrigal ◽  
Sandra Jurado
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Brain ◽  
Arginine Vasopressin ◽  
3D Imaging ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cellular Resolution ◽  
Developing Mouse Brain ◽  
Developmental Dynamics ◽  
Appropriate Social Behaviors

AbstractOxytocin (OXT) and arginine vasopressin (AVP) support a broad range of behaviors and homeostatic functions including sex-specific and context-appropriate social behaviors. Although the alterations of these systems have been linked with social-related disorders such as autism spectrum disorder, their formation and developmental dynamics remain largely unknown. Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented cellular resolution. A systematic quantification indicates that OXT and AVP neurons in the hypothalamus display distinctive developmental dynamics and high cellular plasticity from embryonic to early postnatal stages. Our findings reveal new insights into the specification and consolidation of neuropeptidergic systems in the developing CNS.

The role of eye contact in young children’s judgments of others’ visibility: A comparison of preschoolers with and without autism spectrum disorder

2021 ◽  
Vol 89 ◽  
pp. 106075
Author(s):  
Allie Khalulyan ◽  
Katie Byrd ◽  
Jonathan Tarbox ◽  
Alexandra Little ◽  
Henrike Moll
Keyword(s):  
Autism Spectrum Disorder ◽  
Eye Contact ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals A systematic review and meta-analysis of studies on metaphor comprehension in individuals with autism spectrum disorder: Do task properties matter?

2019 ◽  
Vol 40 (6) ◽  
pp. 1421-1454 ◽  
Author(s):  
Tamar Kalandadze ◽  
Valentina Bambini ◽  
Kari-Anne B. Næss
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Syntactic Structure ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Response Format ◽  
Metaphor Comprehension ◽  
The Relationship

AbstractIndividuals with autism spectrum disorder (ASD) often experience difficulty in comprehending metaphors compared to individuals with typical development (TD). However, there is a large variation in the results across studies, possibly related to the properties of the metaphor tasks. This preregistered systematic review and meta-analysis (a) explored the properties of the metaphor tasks used in ASD research, and (b) investigated the group difference between individuals with ASD and TD on metaphor comprehension, as well as the relationship between the task properties and any between-study variation. A systematic search was undertaken in seven relevant databases. Fourteen studies fulfilled our predetermined inclusion criteria. Across tasks, we detected four types of response format and a great variety of metaphors in terms of familiarity, syntactic structure, and linguistic context. Individuals with TD outperformed individuals with ASD on metaphor comprehension (Hedges’ g = −0.63). Verbal explanation response format was utilized in the study showing the largest effect size in the group comparison. However, due to the sparse experimental manipulations, the role of task properties could not be established. Future studies should consider and report task properties to determine their role in metaphor comprehension, and to inform experimental paradigms as well as educational assessment.

Learning Difficulties and Oxidative Stress in Autism Spectrum Disorder: A Review of the Role of Nutritional Interventions

2021 ◽  
Vol 15 (4) ◽  
pp. 422-434
Author(s):  
Maryam Turkestani ◽  
Norah Aldosiry ◽  
Najat Hamed ◽  
Ramesa Shafi Bhat ◽  
Afaf El-Ansary
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorder ◽  
Learning Difficulties ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Nutritional Interventions ◽  
And Oxidative Stress

scholarly journals Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder

2014 ◽  
Vol 8 (9) ◽  
pp. 1134-1145 ◽  
Author(s):  
Mohammad H. Rahbar ◽  
Maureen Samms-Vaughan ◽  
Aisha S. Dickerson ◽  
Katherine A. Loveland ◽  
Manouchehr Ardjomand-Hessabi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Seafood Consumption ◽  
Blood Cadmium
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