Gallstone Disease in Pregnancy

Liver disease in pregnancy Liver function tests in pregnancy Hyperemesis gravidarum Obstetric cholestasis Acute fatty liver of pregnancy Pre-eclampsia HELLP syndrome Spontaneous hepatic rupture Gallstone disease Pancreatitis Budd–Chiari syndrome Viral hepatitis Pre-existing cirrhotic liver disease A number of liver disorders are unique to, or more likely to occur in, pregnancy. These should be considered alongside the other causes of liver disease that occur in non-pregnant patients. Transient mild derangements of LFT are common and rarely require further assessment beyond repeat monitoring to ensure normalization. However, liver disorders in pregnancy often present non-specifically and, therefore. all patients merit formal clinical assessment....

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GALLSTONE DISEASE AND PANCREATITIS IN PREGNANCY

Gastroenterology Clinics of North America ◽

10.1016/s0889-8553(21)00602-6 ◽

1992 ◽

Vol 21 (4) ◽

pp. 803-815

Author(s):

Larry D. Scott

Keyword(s):

Gallstone Disease ◽

In Pregnancy

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Severe Hypertriglyceridemia Induced Pancreatitis in Pregnancy

Case Reports in Obstetrics and Gynecology ◽

10.1155/2014/485493 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Natasha Gupta ◽

Seema Ahmed ◽

Lemuel Shaffer ◽

Paula Cavens ◽

Josef Blankstein

Keyword(s):

Acute Pancreatitis ◽

Rare Complication ◽

Gallstone Disease ◽

Chylous Ascites ◽

Personal History ◽

Physiological Changes ◽

Lipid Abnormality ◽

Severe Hypertriglyceridemia ◽

History Of ◽

In Pregnancy

Acute pancreatitis caused by severe gestational hypertriglyceridemia is a rare complication of pregnancy. Acute pancreatitis has been well associated with gallstone disease, alcoholism, or drug abuse but rarely seen in association with severe hypertriglyceridemia. Hypertriglyceridemia may occur in pregnancy due to normal physiological changes leading to abnormalities in lipid metabolism. We report a case of severe gestational hypertriglyceridemia that caused acute pancreatitis at full term and was successfully treated with postpartum therapeutic plasma exchange. Patient also developed several other complications related to her substantial hypertriglyceridemia including preeclampsia, chylous ascites, retinal detachment, pleural effusion, and chronic pericarditis. This patient had no previous family or personal history of lipid abnormality and had four successful prior pregnancies without developing gestational hypertriglyceridemia. Such a severe hypertriglyceridemia is usually seen in patients with familial chylomicronemia syndromes where hypertriglyceridemia is exacerbated by the pregnancy, leading to fatal complications such as acute pancreatitis.

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Gallstones in pregnancy

British Journal of Hospital Medicine ◽

10.12968/hmed.2020.0330 ◽

2021 ◽

pp. 1-8

Author(s):

ECF Hess ◽

RP Thumbadoo ◽

ECP Thorne ◽

K McNamee

Keyword(s):

Pregnant Women ◽

Gastrointestinal Disease ◽

Gallstone Disease ◽

Developed Countries ◽

Postnatal Period ◽

First Year ◽

Gallstone Pancreatitis ◽

Endoscopic Retrograde ◽

Increased Risk ◽

In Pregnancy

Gallstone disease is the most common gastrointestinal disease in developed countries and is present in up to 15% of the population. Owing to the increased risk factors for gallstones in pregnancy, it is the second most common non-obstetric emergency, affecting up to 12% of pregnant women with a risk of recurrence. Up to 3% of pregnant women in America require a cholecystectomy in the first year after delivery. Gallstone disease has a high risk of developing associated complications, and maternal mortality can be up to 37% if the patient develops gallstone pancreatitis. Endoscopic retrograde cholangiopancreatography and cholecystectomy can be performed safely in the second trimester when benefits outweigh the risks. However, if the patient is able to be managed conservatively, then a cholecystectomy should be performed in the postnatal period to avoid further recurrences and complications. Despite this, there is currently no national UK guidance on how to manage gallstones and related diseases during pregnancy.

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The course and outcomes of complicated gallstone disease in pregnancy: Experience of a tertiary center

Journal of Turkish Society of Obstetric and Gynecology ◽

10.4274/tjod.65475 ◽

2016 ◽

Vol 13 (4) ◽

pp. 178-182 ◽

Cited By ~ 5

Author(s):

Mehmet İlhan ◽

Gülşah İlhan ◽

Ali Fuat Kaan Gök ◽

Kayıhan Günay ◽

Cemalettin Ertekin

Keyword(s):

Gallstone Disease ◽

Tertiary Center ◽

In Pregnancy

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Association of complicated gallstone disease in pregnancy and adverse birth outcomes

The American Journal of Surgery ◽

10.1016/j.amjsurg.2020.01.038 ◽

2020 ◽

Vol 220 (3) ◽

pp. 745-750

Author(s):

Jason M. Bowie ◽

Richard Y. Calvo ◽

Vishal Bansal ◽

Lyndsey E. Wessels ◽

William J. Butler ◽

...

Keyword(s):

Birth Outcomes ◽

Gallstone Disease ◽

Adverse Birth Outcomes ◽

In Pregnancy

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Course and outcomes of complicated gallstone disease in pregnancy: a single centre experience

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20192900 ◽

2019 ◽

Vol 7 (7) ◽

pp. 2686

Author(s):

Nihida Akhter ◽

Irfan Nazir Mir ◽

Sheikh Viqar Manzoor

Keyword(s):

Laparoscopic Cholecystectomy ◽

Average Length ◽

Open Cholecystectomy ◽

Gallstone Disease ◽

Length Of Hospital Stay ◽

Delay In Diagnosis ◽

Medical College ◽

Skilled Personnel ◽

Symptomatic Gallstone Disease ◽

In Pregnancy

Background: The incidence of acute abdomen during pregnancy is approximately 1 in 500 pregnancies. The incidence of symptomatic gallstone disease in pregnancy is reported in approximately 0.2-0.5 per 1,000 pregnancies. Symptoms are similar to those in the nonpregnant state. A delay in diagnosis may increase the risk of perforation. Treatment in most cases is conservative. However, recent trends, newer instrumentation and skilled personnel encourage arranging laparoscopic cholecystectomy at the time of diagnosis.Methods: This study was a retrospective study, included 117 pregnant patients with acute gallstone disease, who were treated and followed-up at Government Medical College, Srinagar, Department of General Surgery and Department of Gynae And Obstetrics, between January 2015 and April 2017.Results: The mean age of patients in our study was 28.6 years. Majority of patients 56 (47.86%) were in is trimester of pregnancy. Parity of the patients varied from 1 to 6, with a mean parity of 2.67. The presentation of majority of patients was colicky pain right upper abdomen,108 (92.30%). All patients had gallstones on USG scan.101(86.32%) patients had acute cholecystitis, while 8 (6.83%) patients had predominant features of acute pancreatitis,8(6.83%) patients had accompanying choledocholithiasis The average wall thickness of gallbladder in our patients was 4.62 mm. Majority 106 (90.59%) patients were managed conservatively. 8 (6.83%) patients underwent cholecystectomy in same admission, after failure of conservative management, 7 patients underwent laparoscopic cholecystectomy and one underwent open cholecystectomy. 3 patients (2.56%), who had features of cholangitis were managed by ERCP. The average length of hospital stay in our patient group was 8.61 days. There was one maternal death reported in our study, there were a total of 8 (6.83%) preterm deliveries.Conclusions: Symptomatic gallstone disease in pregnancy is a common surgical problem. Diagnosis during pregnancy can be difficult, majority of cases can be managed conservatively, intervention whenever indicated must be undertaken.

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