Dyslipidemia and its associated factors in southern Iranian women, Bandare-Kong Cohort study, a cross-sectional survey

Dyslipidemia, a major risk factor for cardiovascular diseases, has become a global issue. Due to the variations in the prevalence of dyslipidemia, this study aimed to evaluate dyslipidemia and its associated factors in women of the Bandare-Kong Cohort Study (BKNCD). This study was conducted on women from the population-based BKNCD, as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). Sociodemographic data, medical history, and anthropometric indices were collected. Dyslipidemia was defined as any lipid abnormality including low-density lipoprotein (LDL) ≥ 160, total cholesterol (TC) ≥ 240, high-density lipoprotein (HDL) < 40, or triglyceride > 200 mg/dl. From the 2223 women in this study (mean age: 48.28 ± 9.26 years), dyslipidemia was observed in 851 (38.3%). High TC was the most common lipid abnormality (18.5%) followed by high LDL (17.7%). Dyslipidemia was most prevalent among women aged 55–70 years, the married, those with < 6 years of education, the unemployed, the overweight or obese, with low socioeconomic status, diabetes, hypertension, and high waist circumference, those using the hookah and living in urban areas. Logistic regression revealed that women with high waist-to-hip ratio (WHR) (OR = 2.22, 95% CI 1.60–3.08), those aged 45–54 years (OR = 1.34, 95% CI 1.07–1.68) and 55–70 years (OR = 1.33, 95% CI 1.03–1.72), and those living in urban areas (OR = 1.35, 95% CI 1.05–1.73) were at significantly increased risk of dyslipidemia. In addition, the results were confirmed using deep neural network models. Dyslipidemia was highly prevalent in Iranian women in the southern coastal region. Central obesity, age over 45 years, and living in urban areas appear to be relatively significant risk factors for dyslipidemia among women.

PROSPECTIVE CROSS SECTIONAL STUDY OF INCIDENCE AND CORRELATION OF DYSLIPIDEMIA IN PREDICTING OUTCOME OF PATIENTS DIAGNOSED WITH CEREBROVASCULAR ACCIDENT AT MMCH, MADHUBANI, BIHAR

Introduction: Lipid abnormality has been described as one of the risk factor for ischemic stroke. However, there are limited studies comparing stroke pattern (infarction and hemorrhage) with lipid prole of patients. Study aimed to study incidence and correlation of lipid abnormality in cerebrovascular accident (CVA) patients. Material And Methods: Hundred and twenty seven subjects were studied after dividing in to Cases (n=102, with CVA) and Control (n=25, without CVA) in the Department of Medicine, Madhubani Medical College and Hospital, Madhubani, Bihar between January 2020 to December 2020. Detailed history and lipid prole was recorded for each subject. Stroke pattern was analyzed using brain CT/MRI for each patient. Results: Most of the subjects among Cases and Control belong to the age groups of 61-85 years (45.09%) followed by 41-60 years (44%) respectively. Among Cases, maximum patients were males (61.76%) whereas among Control, maximum patients were females (84%). Most of the cases were smokers (53.92%). Among smokers of Case group, infarction (55%) was more common compared to hemorrhage (51%). Dyslipidemia was more common among cases (56.86%) compared to control (28%) (p=0.009). Majority of patients (63.07%) with infarct had dyslipidemia as compared to patients with hemorrhage (45.94%). Decreased high density lipoprotein (HDL) level (74%) was the main culprit among Cases followed by decreased total cholesterol (64%). Out of 14 expired patients in Cases, 71.42% had dyslipidemia. Conclusion: Decreased level of HDL was most commonly reported among ischemic compared to hemorrhagic stroke. Dyslipidemia was most commonly reported in patients who died because of stroke.

Dyslipidemia and Its Associated Factors in Women of the Bandare-Kong Cohort Study

Background: Dyslipidemia, a major risk factor for cardiovascular diseases, has become a global issue. Due to geographic and demographic variations in the prevalence of dyslipidemia, this study aimed to evaluate dyslipidemia and its associated factors in women of the Bandare-Kong Cohort Study (BKNCD).Methods: This study was conducted on women from the population-based BKNCD, as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). Sociodemographic data, medical history, and anthropometric indices were collected. Diastolic blood pressure, systolic blood pressure, fasting plasma glucose, serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Daily calorie intake and weekly metabolic equivalent of tasks were also recorded. Dyslipidemia was defined as any lipid abnormality based on the Adult Treatment Panel III criteria. Results: From the 2223 women in this study (mean age: 48.28±9.26 years), dyslipidemia was observed in 1884 (84.8%). High TC was the most common lipid abnormality (53.9%) followed by low HDL (50.8%). Dyslipidemia was most prevalent among women aged 65-70 years, the widowed, illiterate, unemployed, and overweight, with very low socioeconomic status, diabetes, and high waist circumference, hypertension, those using hookah and living in urban areas. Logistic regression revealed that only women with high WHR were at increased risk of dyslipidemia (OR=2.48, 95% CI:1.75-3.53, P<0.001). Having a high school diploma (OR=0.57, 95% CI:0.37-0.89, P=0.015) and living in rural areas (OR=0.68 95% CI:0.49-0.96, P=0.028) were protective.Conclusions: Dyslipidemia was highly prevalent in women of BKNCD. High WHR appears to be the only significant risk factor for dyslipidemia.

Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

INTRODUCTION: Hypothyroidism is the most common cause of secondary dyslipidemia. Thus, thyroid function test should be carried out before starting any hypolipidemic drugs. Even among thyroid disorder, hypothyroidism is more associated with cardiovascular and associated problems and if not detected earlier, it leads to severe clinical consequences. Our study assesses the frequency and spectrum of dyslipidemia in various types of thyroidal illness in the population residing in south western part of Nepal.MATERIALS AND METHODS: This is a cross sectional study carried out in suspected thyroid disorder patients (n=276) and categorized as Euthyroidism (n=55), Subclinical Hypothyroidism (n=89), Primary Hypothyroidism (n=122) and Primary Hyperthyroidism (n=10) patients and to see the association with lipid profiles in the Department of Biochemistry, Universal College of Medical Sciences Teaching Hospital, Bhairahawa Nepal. Serum fT / fT4 and TSH estimations were carried out by competitive 3 ELISA method and Sand-wich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criteria for dyslipidemia was obtained by National Cholesterol Education Expert Panel/ Adult Treatment Protocol III (NCEP/ATPIII).RESULTS: Out of 276 cases the dyslipidemia was observed in 183 cases (66.30%).The dyslipidemia was mostly associated with primary hypothyroidism (55.07%) followed by Subclinical Hypothyroidism (38.04%) than Euthyroid (5.79 %) and Primary Hyperthyroidism (3.62 %) respectively. Out of all cases, the spectrum of dyslipidemia was mostly observed for decreased HDL (18.5 %) followed by increased TG (10.1 %). Moreover, it is significantly differ in relation in HDL (p=0.009), TG/HDL (p=0.02) and Non-HDL/HDL (p=0.033) where as non significant as compared to other lipid profile in different groups.CONCLUSION: Our study revealed the close association of thyroidal illness with dyslipidemia with increased TG, low HDL, increased TG/HDL and Non-HDL/HDL. The increased TG/HDL and/or Non-HDL/HDL could be better indicator than single lipid abnormality which needs to be ascertained prospectively in large population. Journal of Universal College of Medical Sciences (2016) Vol.04 No.02 Issue 14, page: 20-24

Severe Hypertriglyceridemia Induced Pancreatitis in Pregnancy

Acute pancreatitis caused by severe gestational hypertriglyceridemia is a rare complication of pregnancy. Acute pancreatitis has been well associated with gallstone disease, alcoholism, or drug abuse but rarely seen in association with severe hypertriglyceridemia. Hypertriglyceridemia may occur in pregnancy due to normal physiological changes leading to abnormalities in lipid metabolism. We report a case of severe gestational hypertriglyceridemia that caused acute pancreatitis at full term and was successfully treated with postpartum therapeutic plasma exchange. Patient also developed several other complications related to her substantial hypertriglyceridemia including preeclampsia, chylous ascites, retinal detachment, pleural effusion, and chronic pericarditis. This patient had no previous family or personal history of lipid abnormality and had four successful prior pregnancies without developing gestational hypertriglyceridemia. Such a severe hypertriglyceridemia is usually seen in patients with familial chylomicronemia syndromes where hypertriglyceridemia is exacerbated by the pregnancy, leading to fatal complications such as acute pancreatitis.