Problems During Delivery as an Etiology of Cerebral Palsy in Full-Term Infants

Grey matter brain injuries are common in Ugandan children with cerebral palsy suggesting a perinatal aetiology in full-term infants

Acta Paediatrica ◽

10.1111/apa.13352 ◽

2016 ◽

Vol 105 (6) ◽

pp. 655-664 ◽

Cited By ~ 5

Author(s):

Angelina Kakooza-Mwesige ◽

Rosemary K. Byanyima ◽

James K. Tumwine ◽

Ann-Christin Eliasson ◽

Hans Forssberg ◽

...

Keyword(s):

Cerebral Palsy ◽

Grey Matter ◽

Brain Injuries ◽

Full Term ◽

Term Infants ◽

Children With Cerebral Palsy

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Differences in walking attainment ages between low-risk preterm and healthy full-term infants

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2012000800007 ◽

2012 ◽

Vol 70 (8) ◽

pp. 593-598 ◽

Cited By ~ 9

Author(s):

Ana P. Restiffe ◽

José Luiz D. Gherpelli

Keyword(s):

Cerebral Palsy ◽

Birth Weight ◽

Prospective Study ◽

Preterm Infants ◽

Motor Development ◽

Full Term ◽

Term Infants ◽

Gross Motor ◽

Gross Motor Development ◽

Predictive Variables

OBJECTIVE: To compare gross motor development of preterm infants (PT) without cerebral palsy with healthy full-term (FT) infants, according to Alberta Infant Motor Scale (AIMS); to compare the age of walking between PT and FT; and whether the age of walking in PT is affected by neonatal variables. METHODS: Prospective study compared monthly 101 PT and 52 FT, from the first visit, until all AIMS items had been observed. Results: Mean scores were similarity in their progression, except from the eighth to tenth months. FT infants were faster in walking attainment than PT. Birth weight and length and duration of neonatal nursery stay were related to walking delay. CONCLUSION: Gross motor development between PT and FT were similar, except from the eighth to tenth months of age. PT walked later than FT infants and predictive variables were birth weight and length, and duration of neonatal intensive unit stay.

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Developmental Features of Corpus Callosum in Children Revealed by MRI

Pediatrician (St Petersburg) ◽

10.17816/ped9137-48 ◽

2018 ◽

Vol 9 (1) ◽

pp. 37-48 ◽

Cited By ~ 1

Author(s):

Pavel A. Zykin ◽

Anatolij N. Yalfimof ◽

Timofey A. Aleksandrov ◽

Elena I. Krasnoshchekova ◽

Lyubov A. Tkachenko ◽

...

Keyword(s):

Cerebral Palsy ◽

Corpus Callosum ◽

Preterm Infants ◽

Full Term ◽

Control Group ◽

Relative Area ◽

Term Infants ◽

Mean Values ◽

Children With Cerebral Palsy ◽

Developmental Features

With the wide use of magnetic resonance imaging (MRI) in clinical practice, more attention is paid to corpus callosum hypoplasia in children with various central nervous system diseases, including the cerebral palsy. We compared the areas of corpus callosum segments on the mid-sagittal MR images of the children with cerebral palsy and a control group; full-term infants and preterm infants. During the postnatal development, overall callosum area naturally increases, but single segments change differently in both absolute and relative values. In the control group, the relative area of the splenium grew insignificantly, whereas for the genu, it was stable. Children with cerebral palsy also show age-specific growth, but the area of corpus callosum is smaller compared with equal age children in the control group. We found an increased relative area of corpus callosum genu and a decrease of anterior body and splenium in the cerebral palsy group compared with the control group. The kCC index shows higher values in the control group than in any age subgroup of children with cerebral palsy. Mean values for the control group steadily increase with age, whereas in the cerebral palsy group, they remain the same. For every age-specific group, the difference of kCC was statistically significant. Mean kCC index values depend on gestational age and are statistically lower in preterm infants compared with full-term infants. Selective corpus callosum hypoplasia found in the current research could be due to Wallerian degeneration or a decreased number of axons in some of its segments. This could be explained by the disruption of neurogenesis in certain cortical areas. The morphometric index kCC can be used to detect deviations in the corpus callosum structure associated with prematurity and cerebral palsy.

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