A Movement toward Precision Medicine in Acute Brain Injury: The Role of the Cerebral Venous System

2018 ◽  
pp. 245-253
Author(s):  
Jinqi Luo ◽  
Sheng Chen ◽  
Cesar Reis ◽  
Jianmin Zhang
Keyword(s):  
Brain Injury ◽  
Precision Medicine ◽  
Acute Brain Injury ◽  
Venous System

The Role of Imaging in Acute Brain Injury

2009 ◽  
pp. 783-800
Author(s):  
R. D. Stevens ◽  
A. Pustavoitau ◽  
P. van Zijl
Keyword(s):  
Brain Injury ◽  
Acute Brain Injury

scholarly journals The role of carbon dioxide in acute brain injury

2020 ◽  
Vol 10 (2) ◽  
pp. 81 ◽  
Author(s):  
Jin-Quan Li ◽  
Jian-Guo Xu ◽  
Ru-Ming Deng ◽  
Yong-Chun Liu ◽  
Gang Chen
Keyword(s):  
Carbon Dioxide ◽  
Brain Injury ◽  
Acute Brain Injury

The role of caspase family in acute brain injury: the potential therapeutic targets in the future

2021 ◽  
Vol 19 ◽  
Author(s):  
Anke Zhang ◽  
Zeyu Zhang ◽  
Yibo Liu ◽  
Cameron Lenahan ◽  
Houshi Xu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Biological Function ◽  
Therapeutic Potential ◽  
Critical Role ◽  
Acute Brain Injury ◽  
Therapeutic Effects ◽  
Caspase Inhibitors ◽  
Caspase Family ◽  
Translational Strategies

: The caspase family is commonly involved in the pathophysiology of acute brain injury (ABI) through complex apoptotic, pyroptotic, and inflammatory pathways. Current translational strategies for caspase modulation in ABI primarily focus on caspase inhibitors. Because there are no caspase-inhibiting drugs approved for clinical use on the market, the development of caspase inhibitors remains an attractive challenge for researchers and clinicians. Therefore, we conducted the present review with the aim of providing a comprehensive introduction of caspases in ABI. In this review, we summarized the available evidence and potential mechanisms regarding the biological function of caspases. We also reviewed the therapeutic effects of caspase inhibitors on ABI and its subsequent complications. However, various important issues remain unclear, prompting further verification of the efficacy and safety regarding clinical application of caspase inhibitors. We believe that our work will be helpful to further understand the critical role of the caspase family, and will provide novel therapeutic potential for ABI treatment.

scholarly journals The role of autophagy in acute brain injury: A state of flux?

2019 ◽  
Vol 122 ◽  
pp. 9-15 ◽  
Author(s):  
Michael S. Wolf ◽  
Hülya Bayır ◽  
Patrick M. Kochanek ◽  
Robert S.B. Clark
Keyword(s):  
Brain Injury ◽  
Acute Brain Injury

A Critical Analysis of the Role of the Neurotrophic Protein S100B in Acute Brain Injury

2006 ◽  
Vol 23 (8) ◽  
pp. 1185-1200 ◽  
Author(s):  
Andrea Kleindienst ◽  
M. Ross Bullock
Keyword(s):  
Brain Injury ◽  
Critical Analysis ◽  
Acute Brain Injury ◽  
Protein S100b

scholarly journals Venous system in acute brain injury: Mechanisms of pathophysiological change and function

2015 ◽  
Vol 272 ◽  
pp. 4-10 ◽  
Author(s):  
Sheng Chen ◽  
Yujie Chen ◽  
Liang Xu ◽  
Nathanael Matei ◽  
Jiping Tang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Acute Brain Injury ◽  
Venous System ◽  
Injury Mechanisms ◽  
And Function

The Role of Mechanical Ventilation in Acute Brain Injury

2008 ◽  
Vol 26 (2) ◽  
pp. 543-563 ◽  
Author(s):  
Robert D. Stevens ◽  
Christos Lazaridis ◽  
Julio A. Chalela
Keyword(s):  
Mechanical Ventilation ◽  
Brain Injury ◽  
Acute Brain Injury
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