Diagnosis of Brain Death and Organ Donation After Circulatory Death

2018 ◽  
pp. 309-321
Author(s):  
Anthony A. Sochet ◽  
Alexandra K. Glazier ◽  
Thomas A. Nakagawa
Keyword(s):  
Brain Death ◽  
Organ Donation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Organ Donation

2019 ◽  
pp. 545-551
Author(s):  
Lissi Hansen ◽  
Lauren F. Dunn
Keyword(s):  
Palliative Care ◽  
Brain Death ◽  
Organ Donation ◽  
Organ Procurement ◽  
Federal Regulations ◽  
Donation After Circulatory Death ◽  
Bedside Nurse ◽  
Donation Process ◽  
Organ Procurement Organizations ◽  
Circulatory Death

This chapter examines the organ donation process from the time the bedside nurse recognizes that a patient should be referred for organ donation until organ procurement has been completed. It also discusses when to speak with families about organ donation, how to address family concerns, the clinical triggers for organ donation, differences between brain death donation and donation after circulatory death (DCD), and palliative care for patients who are candidates for DCD. State and federal regulations related to prospective donors and safeguarding standards that are in place for organ procurement organizations (OPO) and hospitals are also included.

scholarly journals A scoping review of the perceptions of death in the context of organ donation and transplantation

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
George Skowronski ◽  
Anil Ramnani ◽  
Dianne Walton-Sonda ◽  
Cynthia Forlini ◽  
Michael J. O’Leary ◽  
...  
Keyword(s):  
Brain Death ◽  
Organ Donation ◽  
Organ Transplantation ◽  
Scoping Review ◽  
Healthcare Professionals ◽  
Solid Organ Transplantation ◽  
Considerable Proportion ◽  
Solid Organ ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Abstract Background Socio-cultural perceptions surrounding death have profoundly changed since the 1950s with development of modern intensive care and progress in solid organ transplantation. Despite broad support for organ transplantation, many fundamental concepts and practices including brain death, organ donation after circulatory death, and some antemortem interventions to prepare for transplantation continue to be challenged. Attitudes toward the ethical issues surrounding death and organ donation may influence support for and participation in organ donation but differences between and among diverse populations have not been studied. Objectives In order to clarify attitudes toward brain death, organ donation after circulatory death and antemortem interventions in the context of organ donation, we conducted a scoping review of international English-language quantitative surveys in various populations. Study appraisal A search of literature up to October 2020 was performed, using multiple databases. After screening, 45 studies were found to meet pre-specified inclusion criteria. Results 32 studies examined attitudes to brain death, predominantly in healthcare professionals. In most, around 75% of respondents accepted brain death as equivalent to death of the person. Less common perspectives included equating death with irreversible coma and willingness to undertake organ donation even if it caused death. 14 studies examined attitudes to organ donation following circulatory death. Around half of respondents in most studies accepted that death could be confidently diagnosed after only 5 min of cardiorespiratory arrest. The predominant reason was lack of confidence in doctors or diagnostic procedures. Only 6 studies examined attitudes towards antemortem interventions in prospective organ donors. Most respondents supported minimally invasive procedures and only where specific consent was obtained. Conclusions Our review suggests a considerable proportion of people, including healthcare professionals, have doubts about the medical and ethical validity of modern determinations of death. The prognosis of brain injury was a more common concern in the context of organ donation decision-making than certainty of death.

Organ donation after circulatory death: please avoid undue haste!

2021 ◽  
Author(s):  
Beatriz Domínguez-Gil ◽  
◽  
Alex R. Manara ◽  
Francis L. Delmonico
Keyword(s):  
Organ Donation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Systemic Complement Activation in Donation After Brain Death Versus Donation After Circulatory Death Organ Donors

2021 ◽  
Author(s):  
Samantha E. Halpern ◽  
Caroline K. Rush ◽  
R. Whitney Edwards ◽  
Todd V. Brennan ◽  
Andrew S. Barbas ◽  
...  
Keyword(s):  
Brain Death ◽  
Complement Activation ◽  
Organ Donors ◽  
Donation After Circulatory Death ◽  
Donation After Brain Death ◽  
Circulatory Death

scholarly journals Liver Transplantation in Children Using Organ Donation After Circulatory Death

JAMA Surgery ◽  
2014 ◽  
Vol 149 (1) ◽  
pp. 77 ◽  
Author(s):  
Johnny C. Hong ◽  
Robert Venick ◽  
Hasan Yersiz ◽  
Prawat Kositamongkol ◽  
Fady M. Kaldas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Organ Donation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Donation after Brain Death versus Donation after Circulatory Death: Lung Donor Management Issues

2018 ◽  
Vol 39 (02) ◽  
pp. 138-147 ◽  
Author(s):  
Bronwyn Levvey ◽  
Kovi Levin ◽  
Miranda Paraskeva ◽  
Glen Westall ◽  
Gregory Snell
Keyword(s):  
Brain Death ◽  
Ex Vivo ◽  
Scoring Systems ◽  
Donation After Circulatory Death ◽  
Donor Pool ◽  
Ex Vivo Lung Perfusion ◽  
Conversion Rates ◽  
Donor Lung ◽  
Donation After Brain Death ◽  
Circulatory Death

AbstractLung transplantation (LTx) has traditionally been limited by a lack of suitable donor lungs. With the recognition that lungs are more robust than initially thought, the size of the donor pool of available lungs has increased dramatically in the past decade. Donation after brain death (DBD) and donation after circulatory death (DCD) lungs, both ideal and extended are now routinely utilized. DBD lungs can be damaged. There are important differences in the public's understanding, legal and consent processes, intensive care unit strategies, lung pathophysiology, logistics, and potential-to-actual donor conversion rates between DBD and DCD. Notwithstanding, the short- and long-term outcomes of LTx from any of these DBD versus DCD donor scenarios are now similar, robust, and continue to improve. Large audits suggest there remains a large untapped pool of DCD (but not DBD) lungs that may yet further dramatically increase lung transplant numbers. Donor scoring systems that might predict the donor conversion rates and lung quality, the role of ex vivo lung perfusion as an assessment and lung resuscitation tool, as well as the potential of donor lung quality biomarkers all have immense promise for the clinical field.

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