Evaluating and extending the Informed Consent Ontology for representing permissions from the clinical domain

The purpose of this study was to evaluate, revise, and extend the Informed Consent Ontology (ICO) for expressing clinical permissions, including reuse of residual clinical biospecimens and health data. This study followed a formative evaluation design and used a bottom-up modeling approach. Data were collected from the literature on US federal regulations and a study of clinical consent forms. Eleven federal regulations and fifteen permission-sentences from clinical consent forms were iteratively modeled to identify entities and their relationships, followed by community reflection and negotiation based on a series of predetermined evaluation questions. ICO included fifty-two classes and twelve object properties necessary when modeling, demonstrating appropriateness of extending ICO for the clinical domain. Twenty-six additional classes were imported into ICO from other ontologies, and twelve new classes were recommended for development. This work addresses a critical gap in formally representing permissions clinical permissions, including reuse of residual clinical biospecimens and health data. It makes missing content available to the OBO Foundry, enabling use alongside other widely-adopted biomedical ontologies. ICO serves as a machine-interpretable and interoperable tool for responsible reuse of residual clinical biospecimens and health data at scale.

Investigation into the Effects of Backrest Angle and Stick Location on Female Strength

Objectives: The purpose of this study was to investigate the effects of backrest angle and hand maneuver direction on maximum hand strength and to recommend a strength value for the hand-controlled stick of an aircraft. Methods: Forty-eight female subjects were recruited to perform simulated forward–backward and adduction–abduction maneuvers using control sticks. Each subject was free from musculoskeletal disorders and pain. The independent variables included four control maneuvers (forward, backward, adduction, abduction), two right-hand control stick locations (central, side), and three backrest angles (90°, 103°, 108°). The dependent variable was maximum hand strength. Results: The maximum strength for forward maneuvers with both central and side sticks was strongest at a 90° backrest angle (p < 0.001). The maximum strength for adduction maneuvers with both central and side sticks was also strongest at a 90° backrest angle (p < 0.001). On the other hand, the highest strength was observed at a 108° backrest angle when pulling the stick backward (p < 0.001). The abduction strength was significantly stronger than the adduction strength with a central stick (p < 0.001), but the adduction strength was significantly stronger than the abduction strength with a side stick (p < 0.001–p = 0.017). The forward and abduction strength were significantly different in different locations (p < 0.001). The recommended strength in the Code of Federal Regulations (CFR) by the US FAA is higher than the strength values observed in this study. Conclusions: The backrest angle, directions, and location affected the muscular strength. The recommended values should be reevaluated and adjusted for Taiwanese pilots.

The fourth industrial revolution: contradictions of the new social reality and its techno-digital security

The article is devoted to the topical topic of the fourth industrial revolution, which every member of society is witnessing and participating in today. The author analyzes the process of forming a new social reality and notes its ambiguous nature. On the one hand, there are obvious innovative breakthroughs in many areas of life that can significantly "improve" human (not only social) existence. On the other hand, the contradictions and paradoxes of such a "brave new world" are exponentially increasing, "deferred" challenges and risks are being formed, moral and ethical algorithms of social interaction are being transformed. The author focuses on the fact that today humanity, in order to form a balanced and safe social environment, needs to delve into the essence of the process of the fourth industrial revolution. To do this, it is necessary not just to comprehend their upcoming scientific and technological "steps", but equally those profound changes that have already been launched. In addition, the article also notes the special role of the COVID-19 pandemic, which, according to many researchers, has forever changed the usual societal contours, forming a kind of "post-pandemic" social reality. The paper analyzes the uniqueness of the situation of "layering" of two transformational processes – the expansion of the fourth industrial revolution and the reformatting of being by the COVID-19 virus. In view of this, as the author notes, a person begins practically, at the level of everyday life, to face an increasing volume of changes generated by these processes, as well as to experience fear of the future and a permanent state of anxiety. Therefore, in the modern social reality, there is an adequate demand for the formation of a "response" to new, including digital challenges and risks, as well as in the strategic development of regulatory and adaptive measures. The author substantiates the need to develop a strategy for techno-digital security and include it in the relevant federal regulations.

Assessment of Antibiotic Resistance Pattern of Bacteria Prevalent during COVID-19 Pandemic

Owing to disparities in the intensity of the breakouts, state and federal regulations, accessible means, cultural elements, and social consciousness, the global reaction to the COVID-19 pandemic has been varied. The COVID-19 pandemic, on the other hand, has had an impact on all parts of society, notably efforts to combat antimicrobial resistance (AMR). The pandemic has highlighted that a greater burden on medical infrastructure can contribute to higher, often unnecessary antibiotic usage and a de-prioritization of antimicrobial stewardship and surveillance (AMS). The focus of this research is to see if there is a growth in antibiotic resistance during the covid-19 pandemic in the King Salman Hospital in Riyadh, Saudi Arabia, and to investigate the subcomponent that leads to antibiotic resistance. This is a comprehensive review of patients hospitalized at the King Salman Hospital in Riyadh, Saudi Arabia, who were admitted to the Intensive Care Unit (ICU) during the first wave of the covid-19 pandemic, which occurred between March and August 2020. An analysis of the case dataset was performed to determine the rise in antibiotic resistance and relate it to resistant cases before the pandemic (September 2019 to February 2020). Before and throughout the pandemic, fifteen kinds of bacteria were found, with K. pneumonia being the most prevalent bacteria (49; 30.6%), and Ac. Baum/haem being the most removable bacteria during the pandemic (74; 37.3%). Cephalosporin antibiotics, in notably cefotaxime and ceftazidime (100%), cefazolin (96.3%), ceftriaxone (96%), cefuroxime and ceftazidime (95%), cefotaxime ((94.7%). These antibiotics also had the same amount of resistance during the pandemic. In pre-covid-19 and during covid-19, these findings were congruent with the penicillin antibiotics class, ampicillin, and piperacillin (96.3% and 92.1%), accordingly. It is presently uncertain if COVID-19 patients would develop new or growing antibiotic resistance in locations with low historical prevalence, but this should be investigated in retrospective and future clinical and microbiology research.

THE CONCEPT AND LEGAL NATURE OF THE LEGAL STATUS OF THE REPRESENTATIVE BODY OF MUNICIPALITIES ON THE TERRITORY OF THE REPUBLIC OF CRIMEA

The article examines the concept of a representative body of municipalities on the territory of the Republic of Crimea, analyzes federal regulations containing the interpretation of the concept of the legal status of a representative body of a municipal formation, as well as regulations of municipalities containing norms that define the competence of representative bodies of a municipality.

Integrating Virtue Ethics into Responsible-Conduct-of-Research Programs: Challenges and Opportunities

In response to federal regulations, institutions created a multitude of responsible-conduct-of-research (RCR) education programs to teach novice researchers about ethical issues that may arise in the course of their research and how to avoid or address them. Many RCR education programs strive to help familiarize trainees with some of the areas in which issues in research ethics and integrity develop and help shape trainees into researchers who conduct their work with integrity. However, the compliance aspect of RCR education programs presents fundamental challenges to the programs’ aspirational goals. Adopting a virtue ethics framework can contribute to RCR education programs’ pursuit of those goals by drawing attention to the ways in which researchers’ characters contribute to conducting research with integrity. Further, virtue ethics can contribute to the development of a virtuous researcher through incorporation into both the formal RCR curriculum and through more informal means, such as mentoring.

Forensic Engineering Analysis Of Golf Course Cart Club And Ball Accidents

With Over 27.8 Million Golfers And More Than 16,000 Golf Facilities In The United States, Golf Is A Non-Contact Sport With Statistically Low Risk For Injury. However, Research Has Documented Golf Related Injuries Can Be Disproportionally Serious Or Even Fatal. Federal Regulations And Countermeasures To Improve Golf Safety Are Outlined. A Spectrum Of Forensic Engineering Analysis Of Golf-Related Incidents Illustrates The Broad Range Of Resulting Trauma. Categories Of Golf Incidents Include: Cart Collisions With Other Vehicles Resulting From Mixed Use On Automotive Roadways, Cart Solo Incidents Including Ejection With And Without Rollover, Errant Golf Ball Impacts, Inadvertent Golf Club Impacts, Trip And Fall Incidents As Well As Golf Cart Fires.

Good Practices For Managing A Safe Chemical Laboratory Part 4: Records, Documents And Regulations

Documenting lab activity promotes safety, provides data useful in safety analysis and planning and creates a paper trail that can be used as evidence of compliance with local, state and federal regulations. Whether in academia or industry, the chemical laboratory must operate in compliance with a large number of regulations. Laboratory records play a large part in incident and accident investigation. Records and documents should be created with very specific goals in mind. They should be designed to meet these goals, preferably by those who ultimately will use them and be “standardized,” as much as possible. They should be subject to change control and retained for a prescribed period of time under conditions that will maintain their integrity. Having approved, written standard operating procedures (SOPs) in place for routine laboratory unit operations provides lab management with another way to leverage safety at the bench level.