Architectural and artistic construction of museum is one of the most complex genres in environment development and design, with its inherent qualities, means of expressiveness, principles of environment and image development, scientific concepts, in the context of historical development, artistic styles and trends. The author of the article considers the artistic lighting design in isolation from the integral dramaturgy of the project to be deeply flawed, and the setting of accent lighting at the final stage Ц to be simple, but not outstanding. Based on extensive hands-on experience in the construction of museum expositions, the author of the article reveals some peculiarities, especially significant to the participants of the lighting system setting for museums and other cultural facilities.