This paper proposed a full vehicle state estimation and developed an integrated chassis control by coordinating electronic stability control (ESC) and torque vectoring differential (TVD) systems to improve vehicle handling and stability in all conditions without any interference. For this purpose, an integrated TVD/ESC chassis system has been modeled in Matlab/Simulink and applied into the vehicle dynamics model of the 2003 Ford Expedition in carsim software. TVD is used to improve handling in routine and steady-state driving conditions and ESC is mainly used as the stability controller for emergency maneuvers or when the TVD cannot improve vehicle handling. By the β−β˙ phase plane, vehicle stable region is determined. Inside the reference region, the handling performance and outside the region the vehicle stability has been in question. In order to control the integrated chassis system, a unified controller with three control layers based on fuzzy control strategy, β−β˙ phase plane, longitudinal slip, and road friction coefficient of each tire is designed in Matlab/Simulink. To detect the control parameters, a state estimator is developed based on unscented Kalman filter (UKF). Bees algorithm (BA) is employed to optimize the fuzzy controller. The performance and robustness of the integrated chassis system and designed controller were conformed through routine and extensive simulations. The simulation results via a co-simulation of MATLAB/Simulink and CarSim indicated that the designed integrated ESC/TVD chassis control system could effectively improve handling and stability in all conditions without any interference between subsystems.