Pathomechanisms of Photoaged Skin

2010 ◽  
pp. 101-107 ◽  
Author(s):  
Jean Krutmann
Keyword(s):  
Photoaged Skin

scholarly journals HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts

2020 ◽  
Vol 295 (8) ◽  
pp. 2483-2494
Author(s):  
Hiroyuki Yoshida ◽  
Mika Aoki ◽  
Aya Komiya ◽  
Yoko Endo ◽  
Keigo Kawabata ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Fold Increase ◽  
Histamine Receptor ◽  
Skin Fibroblasts ◽  
Dependent Manner ◽  
Skin Damage ◽  
Photoaged Skin ◽  
Molecular Sizes ◽  
Ha Synthase ◽  
Hyaluronan Binding

The immune-regulatory compound histamine is involved in the metabolism of the essential skin component hyaluronan (HA). We previously reported that histamine up-regulates the expression of HYBID (hyaluronan-binding protein involved in hyaluronan depolymerization, also called CEMIP or KIAA1199), which plays a key role in HA degradation. However, no information is available about histamine's effects on HA synthase (HAS) expression, the molecular sizes of HA species produced, and histamine receptors and their signaling pathways in skin fibroblasts. Moreover, histamine's effects on photoaged skin remain elusive. Here, we show that histamine increases HA degradation by up-regulating HYBID and down-regulating HAS2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced HA. Histamine H1 blocker abrogated the histamine effects on HYBID up-regulation, HAS2 suppression, and HA degradation. Histamine H1 agonist exhibited effects on HA levels, composition, and breakdown similar to those of histamine. Of note, blockade of protein kinase Cδ or PI3K–Akt signaling abolished histamine-mediated HYBID stimulation and HAS2 suppression, respectively. Immunohistochemical experiments revealed a significant ∼2-fold increase in tryptase-positive mast cells in photoaged skin, where HYBID and HAS2 expression levels were increased and decreased, respectively, compared with photoprotected skin. These results indicate that histamine controls HA metabolism by up-regulating HYBID and down-regulating HAS2 via distinct signaling pathways downstream of histamine receptor H1. They further suggest that histamine may contribute to photoaged skin damage by skewing HA metabolism toward degradation.

scholarly journals Clusterin Associates with Altered Elastic Fibers in Human Photoaged Skin and Prevents Elastin from Ultraviolet-Induced Aggregation in Vitro

2007 ◽  
Vol 171 (5) ◽  
pp. 1474-1482 ◽  
Author(s):  
Elke Janig ◽  
Martin Haslbeck ◽  
Ariane Aigelsreiter ◽  
Nathalie Braun ◽  
Daniela Unterthor ◽  
...  
Keyword(s):  
Elastic Fibers ◽  
Photoaged Skin ◽  
Induced Aggregation

Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin

2018 ◽  
Vol 179 (1) ◽  
pp. 136-144 ◽  
Author(s):  
H. Yoshida ◽  
A. Nagaoka ◽  
A. Komiya ◽  
M. Aoki ◽  
S. Nakamura ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Photoaged Skin

Peroxisome Proliferator-Activated Receptors: Role in Skin Health and Appearance of Photoaged Skin

2016 ◽  
pp. 225-238
Author(s):  
Stacy S. Hawkins ◽  
William Shingleton ◽  
Jean Adamus ◽  
Helen Meldrum
Keyword(s):  
Peroxisome Proliferator ◽  
Photoaged Skin ◽  
Peroxisome Proliferator Activated Receptors

Pathomechanisms of Photoaged Skin

2016 ◽  
pp. 121-129 ◽  
Author(s):  
Jean Krutmann
Keyword(s):  
Photoaged Skin
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