Different from the other distribution center location methods, there are new characteristics in distribution center location during earthquake disaster responses. In this paper, we investigate the factors impacting the location of distribution center during earthquake responses, and propose a decision-making model based on improved AHP framework for this issue. The improved AHP is extended to automatically calculate large scale judgment matrices by the crosstie model. This decision-making model was successfully applied in the simulation case of Yushu earthquake responses in 2010. The results show that the proposed decision-making model is reasonable.