Using Parameterization and Springs to Determine Aneurysm Wall Thickness

2009 ◽  
pp. 397-414 ◽  
Author(s):  
Erick Johnson ◽  
Yongjie Zhang ◽  
Kenji Shimada
Keyword(s):  
Wall Thickness ◽  
Aneurysm Wall

scholarly journals Effect of Aneurysm and Patient Characteristics on Intracranial Aneurysm Wall Thickness

2021 ◽  
Vol 8 ◽  
Author(s):  
Jason M. Acosta ◽  
Anne F. Cayron ◽  
Nicolas Dupuy ◽  
Graziano Pelli ◽  
Bernard Foglia ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Positive Family History ◽  
Patient Characteristics ◽  
Western World ◽  
University Hospitals ◽  
Thickness Uniformity ◽  
Neck Size ◽  
Aneurysm Wall

Background: The circle of Willis is a network of arteries allowing blood supply to the brain. Bulging of these arteries leads to formation of intracranial aneurysm (IA). Subarachnoid hemorrhage (SAH) due to IA rupture is among the leading causes of disability in the western world. The formation and rupture of IAs is a complex pathological process not completely understood. In the present study, we have precisely measured aneurysmal wall thickness and its uniformity on histological sections and investigated for associations between IA wall thickness/uniformity and commonly admitted risk factors for IA rupture.Methods: Fifty-five aneurysm domes were obtained at the Geneva University Hospitals during microsurgery after clipping of the IA neck. Samples were embedded in paraffin, sectioned and stained with hematoxylin-eosin to measure IA wall thickness. The mean, minimum, and maximum wall thickness as well as thickness uniformity was measured for each IA. Clinical data related to IA characteristics (ruptured or unruptured, vascular location, maximum dome diameter, neck size, bottleneck factor, aspect and morphology), and patient characteristics [age, smoking, hypertension, sex, ethnicity, previous SAH, positive family history for IA/SAH, presence of multiple IAs and diagnosis of polycystic kidney disease (PKD)] were collected.Results: We found positive correlations between maximum dome diameter or neck size and IA wall thickness and thickness uniformity. PKD patients had thinner IA walls. No associations were found between smoking, hypertension, sex, IA multiplicity, rupture status or vascular location, and IA wall thickness. No correlation was found between patient age and IA wall thickness. The group of IAs with non-uniform wall thickness contained more ruptured IAs, women and patients harboring multiple IAs. Finally, PHASES and ELAPSS scores were positively correlated with higher IA wall heterogeneity.Conclusion: Among our patient and aneurysm characteristics of interest, maximum dome diameter, neck size and PKD were the three factors having the most significant impact on IA wall thickness and thickness uniformity. Moreover, wall thickness heterogeneity was more observed in ruptured IAs, in women and in patients with multiple IAs. Advanced medical imaging allowing in vivo measurement of IA wall thickness would certainly improve personalized management of the disease and patient care.

Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging

2021 ◽  
pp. neurintsurg-2021-017688
Author(s):  
Xinke Liu ◽  
Junqiang Feng ◽  
Zhixin Li ◽  
Zihao Zhang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Signal Intensity ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Black Blood ◽  
Post Contrast ◽  
Isotropic Resolution ◽  
Aneurysm Size ◽  
Aneurysm Wall

BackgroundThis study was performed to quantify intracranial aneurysm wall thickness (AWT) and enhancement using 7T MRI, and their relationship with aneurysm size and type.Methods27 patients with 29 intracranial aneurysms were included. Three-dimensional T1 weighted pre‐ and post-contrast fast spin echo with 0.4 mm isotropic resolution was used. AWT was defined as the full width at half maximum on profiles of signal intensity across the aneurysm wall on pre-contrast images. Enhancement ratio (ER) was defined as the signal intensity of the aneurysm wall over that of the brain parenchyma. The relationships between AWT, ER, and aneurysm size and type were investigated.Results7T MRI revealed large variations in AWT (range 0.11–1.24 mm). Large aneurysms (>7 mm) had thicker walls than small aneurysms (≤7 mm) (0.49±0.05 vs 0.41±0.05 mm, p<0.001). AWT was similar between saccular and fusiform aneurysms (p=0.546). Within each aneurysm, a thicker aneurysm wall was associated with increased enhancement in 28 of 29 aneurysms (average r=0.65, p<0.05). Thicker walls were observed in enhanced segments (ER >1) than in non-enhanced segments (0.53±0.09 vs 0.38±0.07 mm, p<0.001).ConclusionImproved image quality at 7T allowed quantification of intracranial AWT and enhancement. A thicker aneurysm wall was observed in larger aneurysms and was associated with stronger enhancement.

Observation of cerebral aneurysm wall thickness using intraoperative microscopy: clinical and morphological analysis of translucent aneurysm

2015 ◽  
Vol 36 (6) ◽  
pp. 907-912 ◽  
Author(s):  
Jihye Song ◽  
Jung Eon Park ◽  
Hyoung Ryoul Kim ◽  
Yong Sam Shin
Keyword(s):  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Morphological Analysis ◽  
Aneurysm Wall

scholarly journals Fluid-Structure Simulations of a Ruptured Intracranial Aneurysm: Constant versus Patient-Specific Wall Thickness

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
S. Voß ◽  
S. Glaßer ◽  
T. Hoffmann ◽  
O. Beuing ◽  
S. Weigand ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Ex Vivo ◽  
Thickness Distribution ◽  
Wall Stress ◽  
Patient Specific ◽  
Fluid Structure ◽  
Aneurysm Wall ◽  
Ruptured Intracranial Aneurysm ◽  
Rupture Site

Computational Fluid Dynamics is intensively used to deepen the understanding of aneurysm growth and rupture in order to support physicians during therapy planning. However, numerous studies considering only the hemodynamics within the vessel lumen found no satisfactory criteria for rupture risk assessment. To improve available simulation models, the rigid vessel wall assumption has been discarded in this work and patient-specific wall thickness is considered within the simulation. For this purpose, a ruptured intracranial aneurysm was prepared ex vivo, followed by the acquisition of local wall thickness usingμCT. The segmented inner and outer vessel surfaces served as solid domain for the fluid-structure interaction (FSI) simulation. To compare wall stress distributions within the aneurysm wall and at the rupture site, FSI computations are repeated in a virtual model using a constant wall thickness approach. Although the wall stresses obtained by the two approaches—when averaged over the complete aneurysm sac—are in very good agreement, strong differences occur in their distribution. Accounting for the real wall thickness distribution, the rupture site exhibits much higher stress values compared to the configuration with constant wall thickness. The study reveals the importance of geometry reconstruction and accurate description of wall thickness in FSI simulations.

Fluid-Structure Interactions Abdominal Aortic Aneurysm Models Under the Pulsatile Flow Condition

2000 ◽  
Author(s):  
Chi-Ho Kwon ◽  
Ki-Won Lee ◽  
Young-Ho Kim
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Wall Thickness ◽  
Pulsatile Flow ◽  
Flow Condition ◽  
Fluid Structure Interactions ◽  
Fluid Structure ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Human Cardiovascular System

Abstract Fluid-structure interaction studies were performed on various abdominal aortic aneurysm (AAA) models under the pulsatile flow condition. Eight aneurysm models were made with four different dilatation sizes and two different wall thickness. Stresses and deformations of the aneurysm wall were significantly affected by the dilatation size as well as the wall thickness. The change in wall thickness increased with the more dilated aneurysm. In spite of considerable radial deformations, axial deformations of the aneurysm wall were dominant. The present study showed the strong possibility to understand fluid-structure interactions in the human cardiovascular system.

Evaluation of cerebral aneurysm wall thickness in experimental aneurysms: Comparison of 3T-MR imaging with direct microscopic measurements

2013 ◽  
Vol 156 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Camillo Sherif ◽  
Günther Kleinpeter ◽  
Georg Mach ◽  
Michel Loyoddin ◽  
Thomas Haider ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Aneurysm Wall ◽  
3T Mr

scholarly journals Overestimation of cerebral aneurysm wall thickness by black blood MRI?

2010 ◽  
Vol 31 (3) ◽  
pp. 766-766 ◽  
Author(s):  
David A. Steinman ◽  
Luca Antiga ◽  
Bruce A. Wasserman
Keyword(s):  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Black Blood ◽  
Aneurysm Wall ◽  
Black Blood Mri

Aneurysm Wall Thickness Measurements of Experimental Aneurysms: In Vivo High-Field MR Imaging Versus Direct Microscopy

2014 ◽  
pp. 17-20
Author(s):  
Camillo Sherif ◽  
Günther Kleinpeter ◽  
Michel Loyoddin ◽  
Georg Mach ◽  
Roberto Plasenzotti ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Wall Thickness ◽  
High Field ◽  
Direct Microscopy ◽  
Aneurysm Wall ◽  
High Field Mr ◽  
Thickness Measurements

Indirect measurement of aneurysm wall thickness using digital stethoscope

2010 ◽  
Vol 32 (6) ◽  
pp. 661-665 ◽  
Author(s):  
Liang-Der Jou ◽  
Michel E. Mawad
Keyword(s):  
Wall Thickness ◽  
Indirect Measurement ◽  
Aneurysm Wall
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