Observation of cerebral aneurysm wall thickness using intraoperative microscopy: clinical and morphological analysis of translucent aneurysm

2015 ◽  
Vol 36 (6) ◽  
pp. 907-912 ◽  
Author(s):  
Jihye Song ◽  
Jung Eon Park ◽  
Hyoung Ryoul Kim ◽  
Yong Sam Shin
Keyword(s):  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Morphological Analysis ◽  
Aneurysm Wall

Evaluation of cerebral aneurysm wall thickness in experimental aneurysms: Comparison of 3T-MR imaging with direct microscopic measurements

2013 ◽  
Vol 156 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Camillo Sherif ◽  
Günther Kleinpeter ◽  
Georg Mach ◽  
Michel Loyoddin ◽  
Thomas Haider ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Aneurysm Wall ◽  
3T Mr

scholarly journals Overestimation of cerebral aneurysm wall thickness by black blood MRI?

2010 ◽  
Vol 31 (3) ◽  
pp. 766-766 ◽  
Author(s):  
David A. Steinman ◽  
Luca Antiga ◽  
Bruce A. Wasserman
Keyword(s):  
Cerebral Aneurysm ◽  
Wall Thickness ◽  
Black Blood ◽  
Aneurysm Wall ◽  
Black Blood Mri

SENSITIVITY ANALYSIS OF COMPUTATIONAL STRUCTURAL DYNAMICS IN A CEREBRAL ANEURYSM MODEL TO WALL THICKNESS AND MODEL

2012 ◽  
Vol 12 (03) ◽  
pp. 1250054 ◽  
Author(s):  
ALVARO VALENCIA ◽  
MAXIMILIANO ROJO ◽  
RODRIGO RIVERA ◽  
EDUARDO BRAVO
Keyword(s):  
Cerebral Aneurysm ◽  
Structural Dynamics ◽  
Wall Thickness ◽  
Three Dimensional ◽  
Image Data ◽  
Realistic Model ◽  
Aneurysm Wall ◽  
Computational Structural Dynamics ◽  
Different Thickness ◽  
Aneurysm Model

Intracranial saccular aneurysms tend to be thin walled and stiffer compared with a normal artery. The current work describes computational structural dynamics (CSD) in an anatomically realistic model of a cerebral aneurysm located in the ophthalmic region, using different wall thickness, model data for the artery and aneurysm, and geometry size. The model was obtained from three-dimensional rotational angiography image data. The wall was assumed three-dimensional hyperelastic solid with different thickness in the artery and in the aneurysm regions. The effects of carotid siphon length are reported. The CSD was solved with the finite elements package ADINA. The predictions of stress and strain on the aneurysm wall were compared.

scholarly journals Effect of Aneurysm and Patient Characteristics on Intracranial Aneurysm Wall Thickness

2021 ◽  
Vol 8 ◽  
Author(s):  
Jason M. Acosta ◽  
Anne F. Cayron ◽  
Nicolas Dupuy ◽  
Graziano Pelli ◽  
Bernard Foglia ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Positive Family History ◽  
Patient Characteristics ◽  
Western World ◽  
University Hospitals ◽  
Thickness Uniformity ◽  
Neck Size ◽  
Aneurysm Wall

Background: The circle of Willis is a network of arteries allowing blood supply to the brain. Bulging of these arteries leads to formation of intracranial aneurysm (IA). Subarachnoid hemorrhage (SAH) due to IA rupture is among the leading causes of disability in the western world. The formation and rupture of IAs is a complex pathological process not completely understood. In the present study, we have precisely measured aneurysmal wall thickness and its uniformity on histological sections and investigated for associations between IA wall thickness/uniformity and commonly admitted risk factors for IA rupture.Methods: Fifty-five aneurysm domes were obtained at the Geneva University Hospitals during microsurgery after clipping of the IA neck. Samples were embedded in paraffin, sectioned and stained with hematoxylin-eosin to measure IA wall thickness. The mean, minimum, and maximum wall thickness as well as thickness uniformity was measured for each IA. Clinical data related to IA characteristics (ruptured or unruptured, vascular location, maximum dome diameter, neck size, bottleneck factor, aspect and morphology), and patient characteristics [age, smoking, hypertension, sex, ethnicity, previous SAH, positive family history for IA/SAH, presence of multiple IAs and diagnosis of polycystic kidney disease (PKD)] were collected.Results: We found positive correlations between maximum dome diameter or neck size and IA wall thickness and thickness uniformity. PKD patients had thinner IA walls. No associations were found between smoking, hypertension, sex, IA multiplicity, rupture status or vascular location, and IA wall thickness. No correlation was found between patient age and IA wall thickness. The group of IAs with non-uniform wall thickness contained more ruptured IAs, women and patients harboring multiple IAs. Finally, PHASES and ELAPSS scores were positively correlated with higher IA wall heterogeneity.Conclusion: Among our patient and aneurysm characteristics of interest, maximum dome diameter, neck size and PKD were the three factors having the most significant impact on IA wall thickness and thickness uniformity. Moreover, wall thickness heterogeneity was more observed in ruptured IAs, in women and in patients with multiple IAs. Advanced medical imaging allowing in vivo measurement of IA wall thickness would certainly improve personalized management of the disease and patient care.

Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging

2021 ◽  
pp. neurintsurg-2021-017688
Author(s):  
Xinke Liu ◽  
Junqiang Feng ◽  
Zhixin Li ◽  
Zihao Zhang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Wall Thickness ◽  
Signal Intensity ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Black Blood ◽  
Post Contrast ◽  
Isotropic Resolution ◽  
Aneurysm Size ◽  
Aneurysm Wall

BackgroundThis study was performed to quantify intracranial aneurysm wall thickness (AWT) and enhancement using 7T MRI, and their relationship with aneurysm size and type.Methods27 patients with 29 intracranial aneurysms were included. Three-dimensional T1 weighted pre‐ and post-contrast fast spin echo with 0.4 mm isotropic resolution was used. AWT was defined as the full width at half maximum on profiles of signal intensity across the aneurysm wall on pre-contrast images. Enhancement ratio (ER) was defined as the signal intensity of the aneurysm wall over that of the brain parenchyma. The relationships between AWT, ER, and aneurysm size and type were investigated.Results7T MRI revealed large variations in AWT (range 0.11–1.24 mm). Large aneurysms (>7 mm) had thicker walls than small aneurysms (≤7 mm) (0.49±0.05 vs 0.41±0.05 mm, p<0.001). AWT was similar between saccular and fusiform aneurysms (p=0.546). Within each aneurysm, a thicker aneurysm wall was associated with increased enhancement in 28 of 29 aneurysms (average r=0.65, p<0.05). Thicker walls were observed in enhanced segments (ER >1) than in non-enhanced segments (0.53±0.09 vs 0.38±0.07 mm, p<0.001).ConclusionImproved image quality at 7T allowed quantification of intracranial AWT and enhancement. A thicker aneurysm wall was observed in larger aneurysms and was associated with stronger enhancement.

Modeling the Geometry, Hemodynamics and Tissue Mechanics of Cerebral Aneurysms

2004 ◽  
Author(s):  
Baoshun Ma ◽  
Robert Harbaugh ◽  
Jia Lu ◽  
Madhavan Raghavan
Keyword(s):  
Shear Stress ◽  
Mechanical Stress ◽  
Cerebral Aneurysm ◽  
Residence Time ◽  
Cerebral Aneurysms ◽  
Lesion Size ◽  
Tissue Mechanics ◽  
Particle Residence Time ◽  
Aneurysm Wall ◽  
Geometric Size

The relationship between cerebral aneurysm geometry and biomechanics was investigated. Human cerebral aneurysm geometry was reconstructed from computed tomography angiography (CTA) and refined. Various indices of global geometric (size and shape) features were computed based on differential and computational geometry techniques. Computational fluid dynamics (CFD) simulations were performed to model both steady and pulsatile blood flow in the aneurysm and surrounding vasculature. Hemodynamic indices such as wall shear stress, pressure and particle residence time were obtained. Nonlinear finite element method (FEM) and a reported finite strain constitutive model were employed to estimate the distribution of mechanical stress in the aneurysm wall under static pressure. Shear stress, sac pressure and mechanical stress correlated better with lesion shape while particle residence time correlated better with lesion size.

False cerebral aneurysm associated with metastatic carcinoma of the brain

1974 ◽  
Vol 41 (3) ◽  
pp. 380-382 ◽  
Author(s):  
Abdon Reina ◽  
Robert B. Seal
Keyword(s):  
Cerebral Aneurysm ◽  
Clinical History ◽  
Metastatic Carcinoma ◽  
Malignant Cells ◽  
Carotid Angiography ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Aneurysm Wall ◽  
The Brain ◽  
Fine Print

✓In a patient with metastatic carcinoma of the left frontal lobe, carotid angiography revealed a false cerebral aneurysm arising from the middle cerebral vessels. At craniotomy the aneurysm was found to be surrounded by tumor and cortex. Since the clinical history excluded trauma, it was inferred that the histologically-proven invasion of the aneurysm wall by malignant cells was responsible for the formation of a false cerebral aneurysm.

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